Publication Date:
2014-08-26
Description:
Inactivated poliovirus vaccine (IPV) is efficacious against paralytic disease, but its effect on mucosal immunity is debated. We assessed the efficacy of IPV in boosting mucosal immunity. Participants received IPV, bivalent 1 and 3 oral poliovirus vaccine (bOPV), or no vaccine. A bOPV challenge was administered 4 weeks later, and excretion was assessed 3, 7, and 14 days later. Nine hundred and fifty-four participants completed the study. Any fecal shedding of poliovirus type 1 was 8.8, 9.1, and 13.5% in the IPV group and 14.4, 24.1, and 52.4% in the control group by 6- to 11-month, 5-year, and 10-year groups, respectively (IPV versus control: Fisher's exact test P 〈 0.001). IPV reduced excretion for poliovirus types 1 and 3 between 38.9 and 74.2% and 52.8 and 75.7%, respectively. Thus, IPV in OPV-vaccinated individuals boosts intestinal mucosal immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jafari, Hamid -- Deshpande, Jagadish M -- Sutter, Roland W -- Bahl, Sunil -- Verma, Harish -- Ahmad, Mohammad -- Kunwar, Abhishek -- Vishwakarma, Rakesh -- Agarwal, Ashutosh -- Jain, Shilpi -- Estivariz, Concepcion -- Sethi, Raman -- Molodecky, Natalie A -- Grassly, Nicholas C -- Pallansch, Mark A -- Chatterjee, Arani -- Aylward, R Bruce -- MR/K010174/1/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2014 Aug 22;345(6199):922-5. doi: 10.1126/science.1255006.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉World Health Organization, India-National Polio Surveillance Project, R. K. Khanna Stadium, Africa Avenue, Safdarjung Enclave, New Delhi 110029, India. ; Enterovirus Research Center, Haffkine Institute Compound, Parel, Mumbai, India. ; World Health Organization, Ave Appia, Geneva, Switzerland. sutterr@who.int. ; World Health Organization, Ave Appia, Geneva, Switzerland. ; Panacea Biotec Ltd., New Delhi, India. ; Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Department of Infectious Disease Epidemiology, Imperial College London, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25146288" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Antibodies, Viral/blood/immunology
;
Child
;
Child, Preschool
;
*Disease Eradication
;
Feces/virology
;
Female
;
Humans
;
Immunity, Mucosal
;
Immunization, Secondary
;
India/epidemiology
;
Infant
;
Intestinal Mucosa/*immunology/virology
;
Male
;
Middle Aged
;
Poliomyelitis/epidemiology/immunology/*prevention & control
;
Poliovirus/*immunology/isolation & purification
;
Poliovirus Vaccine, Inactivated/*administration & dosage
;
Poliovirus Vaccine, Oral/*administration & dosage
;
Prevalence
;
Virus Shedding/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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