Publication Date:
1998-12-04
Description:
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, H S -- Pan, Z -- Shi, W -- Brown, B S -- Wymore, R S -- Cohen, I S -- Dixon, J E -- McKinnon, D -- New York, N.Y. -- Science. 1998 Dec 4;282(5395):1890-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9836639" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Animals
;
Anthracenes/pharmacology
;
Brain/metabolism
;
Ganglia, Sympathetic/metabolism
;
Gene Expression
;
Humans
;
Indoles/pharmacology
;
KCNQ2 Potassium Channel
;
KCNQ3 Potassium Channel
;
Kinetics
;
Neurons/drug effects/physiology
;
Oocytes
;
Patch-Clamp Techniques
;
Potassium/*metabolism
;
Potassium Channels/chemistry/drug effects/genetics/*metabolism
;
Potassium Channels, Voltage-Gated
;
Pyridines/pharmacology
;
Rats
;
Sympathetic Nervous System/drug effects/physiology
;
Tetraethylammonium/pharmacology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
