ISSN:
1434-1948
Keywords:
Platinum
;
Uracil
;
Nucleobase
;
Host-guest chemistry
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The open “molecular box” [(en)Pt(U-N1,N3)]4 (1) (where en = ethylenediamine, U = uracil dianion) is able to act as an efficient ligand for additional metal ions. Reactions of the 1,3-alternate conformer of 1 with divalent metal ions result in the formation of octanuclear compounds of the general formula [(en)Pt(U-N1,N3,O2,O4)M]4X8 [M = Cu2+, X = Cl (2a), X = (SO4)0.5 (2b), and M = Co2+ (3), Ni2+ (4), Zn2+ (5) with X = (SO4)0.5], in which the heterometals are bound at the exocyclic oxygen atoms of the uracil nucleobases. The structurally characterized heteronuclear compounds show a 1,3-alternate arrangement of the uracil nucleobases. Pt-M contacts are in the range 2.743(2)-2.804(2) Å; the Pt atoms act as weak σ donors to the heterometals. In spite of the high degree of positive charge associated with compounds 2a-5, they do not behave as hosts for anions. This is a consequence of the orientation of the four nucleobases which, in contrast to a cone arrangement, does not produce a sufficiently large cavity for the incorporation of anions.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
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