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  • 1
    Monograph available for loan
    Monograph available for loan
    The biological chemistry of the elements (2001)
    Oxford [u.a.] : Oxford Univ. Press
    Details Availability
    Call number: M 01.0409
    Type of Medium: Monograph available for loan
    Pages: XVII, 575 S.
    Edition: 2nd ed.
    ISBN: 0198508476
    Classification:
    C.4.1.
    Language: English
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    The application of production functions to the higher education system — some examples from Portuguese universities (1975)
    Springer
    Higher education 4 (1975), S. 447-460 
    Details
    ISSN: 1573-174X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract Production functions were established for the Arts and Law Faculties of Coimbra and Lisbon Universities and for the Higher Institute of Engineering of Lisbon, in which the number of enrolled students was related to the number of professors and assistants. It was possible to find in Coimbra and Lisbon Universities the existence of possibilities of substitution among those factors and economies of scale. In the case of the Higher Institute of Engineering there seems to exist a relation of complementarity between the number of professors and assistants. Also with regard to this Institute, a production function for graduates was estimated which relates them to the expenditures on academic staff and materials. It was found that in this case it was necessary to introduce time as a representative of technological progress, although it was found to be negative. These results are discussed, and the interest and the limitations of the use of production functions for educational management purposes are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00154469
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    Paper (German National Licenses)
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  • 3
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    Role of Raf in vascular protection from distinct apoptotic stimuli (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-07-05
    Description: Raf kinases have been linked to endothelial cell survival. Here, we show that basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) differentially activate Raf, resulting in protection from distinct pathways of apoptosis in human endothelial cells and chick embryo vasculature. bFGF activated Raf-1 via p21-activated protein kinase-1 (PAK-1) phosphorylation of serines 338 and 339, resulting in Raf-1 mitochondrial translocation and endothelial cell protection from the intrinsic pathway of apoptosis, independent of the mitogen-activated protein kinase kinase-1 (MEK1). In contrast, VEGF activated Raf-1 via Src kinase, leading to phosphorylation of tyrosines 340 and 341 and MEK1-dependent protection from extrinsic-mediated apoptosis. These findings implicate Raf-1 as a pivotal regulator of endothelial cell survival during angiogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alavi, Alireza -- Hood, John D -- Frausto, Ricardo -- Stupack, Dwayne G -- Cheresh, David A -- CA45726/CA/NCI NIH HHS/ -- CA50286/CA/NCI NIH HHS/ -- CA75924/CA/NCI NIH HHS/ -- P01 CA78045/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2003 Jul 4;301(5629):94-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12843393" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Cell Survival ; Cells, Cultured ; Chick Embryo ; Endothelial Growth Factors/pharmacology ; Endothelium, Vascular/*cytology/drug effects ; Enzyme Activation ; Enzyme Inhibitors/pharmacology ; Fibroblast Growth Factor 2/pharmacology ; Flavonoids/pharmacology ; Humans ; Intercellular Signaling Peptides and Proteins/pharmacology ; Lymphokines/pharmacology ; MAP Kinase Kinase 1 ; Mitochondria/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Neovascularization, Pathologic ; *Neovascularization, Physiologic/drug effects ; Phosphorylation ; Point Mutation ; Protein Transport ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism ; Proto-Oncogene Proteins B-raf ; Proto-Oncogene Proteins c-raf/chemistry/genetics/*metabolism ; Signal Transduction ; Umbilical Veins ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factors ; p21-Activated Kinases ; src-Family Kinases/antagonists & inhibitors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Tumor regression by targeted gene delivery to the neovasculature (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-29
    Description: Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of targeting vectors specific for endothelial cells in diseased tissues. Here we show that a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes selectively to angiogenic blood vessels in tumor-bearing mice. The therapeutic efficacy of this approach was tested by generating NPs conjugated to a mutant Raf gene, ATPmu-Raf, which blocks endothelial signaling and angiogenesis in response to multiple growth factors. Systemic injection of the NP into mice resulted in apoptosis of the tumor-associated endothelium, ultimately leading to tumor cell apoptosis and sustained regression of established primary and metastatic tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hood, John D -- Bednarski, Mark -- Frausto, Ricardo -- Guccione, Samira -- Reisfeld, Ralph A -- Xiang, Rong -- Cheresh, David A -- CA50286/CA/NCI NIH HHS/ -- P41 RR09784/RR/NCRR NIH HHS/ -- T32 CA09696/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Jun 28;296(5577):2404-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12089446" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphate/metabolism ; Animals ; Apoptosis ; Cations ; Endothelium, Vascular/cytology/metabolism/pathology ; Gene Targeting ; Gene Transfer Techniques ; Genetic Therapy/*methods ; Genetic Vectors ; Humans ; In Situ Nick-End Labeling ; Ligands ; Lipids ; Melanoma, Experimental/blood supply/pathology/therapy ; Mice ; Mice, Inbred BALB C ; Mutation ; *Nanotechnology ; Neoplasm Metastasis ; Neoplasm Transplantation ; Neoplasms, Experimental/blood supply/pathology/*therapy ; Neovascularization, Pathologic/pathology/*therapy ; Proto-Oncogene Proteins c-raf/*genetics/metabolism ; Random Allocation ; Receptors, Vitronectin/*metabolism ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    An Infinite Two-Dimensional Hybrid Water−Chloride Network, Self-Assembled in a Hydrophobic Terpyridine Iron(II) Matrix (2008)
    American Chemical Society
    Details
    Publication Date: 2008-02-08
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by American Chemical Society
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