Publication Date:
1989-01-20
Description:
The systemic administration of either methamphetamine or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to experimental animals produces degenerative changes in nigrostriatal dopaminergic neurons or their axon terminals. This study was conducted to determine if excitatory amino acids, which appear to be involved in various neurodegenerative disorders, might also contribute to the dopaminergic neurotoxicity produced in mice by either methamphetamine or MPTP. MK-801, phencyclidine, and ketamine, noncompetitive antagonists of one subtype of excitatory amino acid receptor, the N-methyl-D-aspartate receptor, provided substantial protection against neurotoxicity produced by methamphetamine but not that produced by MPTP. These findings indicate that excitatory amino acids play an important role in the nigrostriatal dopaminergic damage induced by methamphetamine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sonsalla, P K -- Nicklas, W J -- Heikkila, R E -- New York, N.Y. -- Science. 1989 Jan 20;243(4889):398-400.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurology, University of Medicine and Dentistry of New Jersey--Robert Wood Johnson Medical School, Piscataway 08854.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2563176" target="_blank"〉PubMed〈/a〉
Keywords:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
;
Amino Acids/*physiology
;
Animals
;
Corpus Striatum/*drug effects
;
Dibenzocycloheptenes/*pharmacology
;
Dizocilpine Maleate
;
Dopamine/metabolism
;
Ketamine/pharmacology
;
Methamphetamine/*toxicity
;
Mice
;
*Neurotoxins
;
Phencyclidine/pharmacology
;
Pyridines/*toxicity
;
Substantia Nigra/*drug effects
;
Tyrosine 3-Monooxygenase/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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