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  • 1
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    Bayesian age modelling applied to palaeoflood geochronologies and the investigation of Holocene flood magnitude and frequency (2011)
    Sage
    In: Holocene
    Details
    Publication Date: 2011-12-23
    Description: A new methodology, based on Bayesian age modelling, is presented for the analysis of palaeoflood geochronologies and palaeodischarge data. Bayesian age models were developed, using the Oxcal radiocarbon calibration software, for the geochronologies of three palaeoflood sites in Spain, namely the Gaudalentín, Tagus and Llobregat rivers in SE, Central and NE Spain, respectively. The age–depth plots resulting from the applied Sequence models enabled the construction of flood magnitude-frequency plots through substitution of the original stratigraphic depth data with the associated minimum discharge quantified by hydraulic modelling. The age models presented demonstrate that a Bayesian approach for analyzing Holocene flood magnitude and frequency prevents the loss of geomorphic and hydrologic information inherent in radiocarbon frequency methods previously used in the analysis of palaeoflood data sets. Frequency approaches do not allow proper consideration of flood magnitude information and only incorporate those geomorphic units specifically dated. The Bayesian age models calculate modeled ages for undated units as well, so that all the individual flood events identified in the field can be incorporated and visualized in the data output. The palaeoflood age models therefore illustrate: (1) the age range for clusters of palaeoflood events; (2) the number of events within each flood cluster, with an age estimate and palaeodischarge value for each event; and (3) the potential impact of discharge censoring on the record, for example the role of accommodation space infilling on the quantification of palaeodischarge. The methodology and results are briefly discussed within the wider context of fluvial palaeohydrology, in particular: (1) the role of Bayesian modelling in future fluvial palaeohydrology research; and (2) the value of bedrock gorge sites for investigating past flood–climate relationships, given the problems of deciphering allogenic and autogenic drivers in alluvial sedimentary records.
    Print ISSN: 0959-6836
    Electronic ISSN: 1477-0911
    Topics: Geography , Geosciences
    Published by Sage
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  • 2
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    Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-08-07
    Description: The functions of many open reading frames (ORFs) identified in genome-sequencing projects are unknown. New, whole-genome approaches are required to systematically determine their function. A total of 6925 Saccharomyces cerevisiae strains were constructed, by a high-throughput strategy, each with a precise deletion of one of 2026 ORFs (more than one-third of the ORFs in the genome). Of the deleted ORFs, 17 percent were essential for viability in rich medium. The phenotypes of more than 500 deletion strains were assayed in parallel. Of the deletion strains, 40 percent showed quantitative growth defects in either rich or minimal medium.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winzeler, E A -- Shoemaker, D D -- Astromoff, A -- Liang, H -- Anderson, K -- Andre, B -- Bangham, R -- Benito, R -- Boeke, J D -- Bussey, H -- Chu, A M -- Connelly, C -- Davis, K -- Dietrich, F -- Dow, S W -- El Bakkoury, M -- Foury, F -- Friend, S H -- Gentalen, E -- Giaever, G -- Hegemann, J H -- Jones, T -- Laub, M -- Liao, H -- Liebundguth, N -- Lockhart, D J -- Lucau-Danila, A -- Lussier, M -- M'Rabet, N -- Menard, P -- Mittmann, M -- Pai, C -- Rebischung, C -- Revuelta, J L -- Riles, L -- Roberts, C J -- Ross-MacDonald, P -- Scherens, B -- Snyder, M -- Sookhai-Mahadeo, S -- Storms, R K -- Veronneau, S -- Voet, M -- Volckaert, G -- Ward, T R -- Wysocki, R -- Yen, G S -- Yu, K -- Zimmermann, K -- Philippsen, P -- Johnston, M -- Davis, R W -- HG00185-02/HG/NHGRI NIH HHS/ -- HG01627/HG/NHGRI NIH HHS/ -- HG01633/HG/NHGRI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Aug 6;285(5429):901-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10436161" target="_blank"〉PubMed〈/a〉
    Keywords: Culture Media ; *Gene Deletion ; Gene Expression Regulation, Fungal ; Gene Targeting ; *Genes, Essential ; Genes, Fungal ; *Genome, Fungal ; *Open Reading Frames ; Phenotype ; Polymerase Chain Reaction ; Recombination, Genetic ; Saccharomyces cerevisiae/*genetics/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease (2005)
    Oxford, UK : Blackwell Science Ltd
    International journal of immunogenetics 32 (2005), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Recent studies have reported the association of a pro-inflammatory profile of genetic polymorphisms in IL-1B, IL-1RN, TNF-A, and IL-10 genes with an increased risk of non-cardia gastric cancer. Because gastric cancer and duodenal ulcer are mutually exclusive outcomes of Helicobacter pylori infection, we aimed to investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer. Genomic DNA from 118 patients with duodenal ulcer and 97 healthy controls was typed for the IL-1B polymorphisms at positions −511, −31, and +3954, the VNTR polymorphism in intron 2 of the IL-1RN gene, the TNFA−308, TNFA −238, and the NcoI and BsI LTA polymorphisms by PCR, SSCP and TaqMan assays. H. pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) use was investigated in patients and controls. Logistic regression analysis identified H. pylori infection (OR: 12.86; 95%CI: 3.85–43), NSAID use (OR: 11.95; 95%CI: 4.19–34.05), and family history-ulcer (OR: 3.79; 95%CI: 1.68–8.54) as independent risk factors for duodenal ulcer. When the effect of the combinations of IL-1 and TNF genotypes was studied we found that the distribution of all possible combinations of these eight polymorphisms was similar in duodenal ulcer patients and controls. The simultaneous carriage of alleles IL-1RN*2/IL-1B −31T/IL-1B −511C/IL-IB +3954C/TNF-HaplotypeE negative (termed in some studies as ‘low-producing’ alleles) was increased in H. pylori-positive duodenal ulcer patients compared to H. pylori-infected healthy controls (10.5% vs. 5.9%) although the difference did not reach statistical significance (OR: 1.85; 95%CI: 0.57–5.99, P = 0.41). Moreover, no differences were found with respect to H. pylori status, NSAID use, age, gender, smoking habit, type of complication, recurrence of the ulcer, and need for surgical treatment. Our data show no association between allelic variants of IL-1 and TNF gene polymorphisms in the susceptibility to and final outcome of duodenal ulcer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.2005.00528.x
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  • 4
    Electronic Resource
    Electronic Resource
    Transition from order to chaos in molecular wave functions and spectra (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 6401-6404 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: In this Communication we describe how the transition from regularity to classical chaos in molecular Hamiltonian systems shows up at the quantum level in the structure of the corresponding wave functions and spectra. By changing the value of (h-dash-bar) we show how the scars result from combinations of regular wave functions. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.471301
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  • 5
    Electronic Resource
    Electronic Resource
    Local frequency analysis and the structure of classical phase space of the LiNC/LiCN molecular system (1998)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 108 (1998), S. 63-71 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The phase space structure of a generic Hamiltonian model, describing the vibrational dynamics of the LiNC/LiCN molecular system, is studied using a frequency analysis method. The results obtained for the regular region constitute a true parametrization of the corresponding invariant tori on which the trajectories are located. By performing the frequency analysis locally, much richer information about chaotic trajectories is obtained, since it clearly reveals the dynamical characteristics of trajectory fragments hidden behind the t→∞ ergodic property. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.475365
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  • 6
    Electronic Resource
    Electronic Resource
    Saddle-node bifurcations in the LiNC/LiCN molecular system: Classical aspects and quantum manifestations (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 5068-5081 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A classical-quantum correspondence study of a saddle-node bifurcation in a realistic molecular system is presented. The relevant classical structures (periodic orbits and manifolds) and its origin are examined in detail. The most important conclusion of this study is that, below the bifurcation point, there exists an infinite sequence of precursor orbits, which mimic for a significant period of time the (future) saddle-node orbits. These structures have a profound influence in the quantum mechanics of the molecule and several vibrational wave functions of the system present a strong localization along the saddle-node periodic orbits. A striking result is that this scarring effect also takes place well below the bifurcation energy, which constitutes a manifestation of the so-called "ghost'' orbits in configuration and phase space. This localization effect has been further investigated using wave packet dynamics. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472351
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  • 7
    Electronic Resource
    Electronic Resource
    A periodic orbit analysis of the vibrationally highly excited LiNC/LiCN: A comparison with quantum mechanics (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 2921-2931 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: By constructing continuation/bifurcation diagrams of families of periodic orbits of LiNC/LiCN system the spectroscopy and dynamics for this species are deduced and compared with accurate quantum mechanical calculations up to 13 000 cm−1. The interesting phenomenon of the appearance of gaps in the continuation diagram of the principal family that corresponds to the bend motion is shown to occur in both isomers, LiNC and LiCN. Through semiclassical quantization a one to one correspondence of specific periodic orbits to certain eigenstates is demonstrated. One interesting example is the case of periodic orbits that are generated from a saddle-node bifurcation and describe rotations of the Li+ ion around the CN− fragment. The correspondence of these periodic orbits to regular rotating type eigenfunctions is shown, thus, demonstrating in a clear way the importance of the saddle-node bifurcations in locating localized wavefunctions in highly energized molecules. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.471113
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  • 8
    Electronic Resource
    Electronic Resource
    Theoretical analysis of the effects of light intensity on the photocorrosion of semiconductor electrodes (1985)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 89 (1985), S. 3429-3434 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100261a054
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  • 9
    Electronic Resource
    Electronic Resource
    Dynamical study of the reaction 1,1,1-trifluoroethane & hydrogen fluoride + 1,1-difluoroethene by classical trajectories (1988)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 5028-5035 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100328a040
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis and properties of monocyclopentadienyltitanium compounds
    Amsterdam : Elsevier
    Journal of Organometallic Chemistry 269 (1984), S. 267-272 
    Details
    ISSN: 0022-328X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-328X(84)80312-5
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