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  • 1
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    Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus eggs (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-07-22
    Description: Fertilization initiates in the egg a dramatic increase in intracellular calcium that opens ion channels and causes exocytosis. To explore the possibility that these events might involve a receptor-mediated pathway, receptors for serotonin or acetylcholine (M1 muscarinic) were expressed in the Xenopus egg; serotonin or acetylcholine then could initiate a series of responses similar to those normally initiated by sperm. Thus, there may be an endogenous receptor in the egg membrane that is activated by sperm, and the serotonin or M1 muscarinic receptor may replace the sperm receptor in this pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kline, D -- Simoncini, L -- Mandel, G -- Maue, R A -- Kado, R T -- Jaffe, L A -- New York, N.Y. -- Science. 1988 Jul 22;241(4864):464-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of Connecticut Health Center, Farmington 06032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3134693" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; Cytoplasmic Granules/physiology ; Endocytosis ; Exocytosis ; Female ; *Fertilization ; GTP-Binding Proteins/physiology ; Genetic Engineering ; Inositol Phosphates/physiology ; Male ; Membrane Potentials ; Receptors, Muscarinic/*physiology ; Receptors, Serotonin/*physiology ; Sperm-Ovum Interactions ; Xenopus laevis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Selective induction of brain type II Na+ channels by nerve growth factor. (1988)
    National Academy of Sciences
    Details
    Publication Date: 1988-02-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
    Electronic Resource
    Electronic Resource
    Differential expression of sodium channels and nicotinic acetylcholine receptor channels in nnr variants of the PC12 pheochromocytoma cell line (1995)
    Springer
    The journal of membrane biology 144 (1995), S. 71-80 
    Details
    ISSN: 1432-1424
    Keywords: Sodium channels ; Acetylcholine receptor channels ; Patch clamping ; Gene expression ; PC12 cells ; Regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract An important component of neuronal differentiation is the tightly controlled expression of a spectrum of ion channel proteins. Ion channels play a critical role in the generation and propagation of action potentials as well as in the cellular response to neurotransmitters, and thus are central in the transfer and integration of information in the nervous system. A model system amenable to analysis of ion channel expression and neuronal differentiation is the rat pheochromocytoma (PC12) cell line. Here, we have used electrophysiological and molecular biological approaches to analyze the expression of voltage-dependent sodium (Na) channels and nicotinic acetylcholine receptors (nAChR) in mutagenized variants (nnr cells) of the PC12 cell line. Our data reveal striking differences in the expression of these channels when compared to wild-type PC12 cells. Even in the absence of nerve growth factor (NGF), nnr cells express functional Na channels and Na channel mRNA at levels exceeding those in wild-type PC12 cells differentiated with NGF. In contrast, acetylcholine-induced currents were evident in only a small proportion of cells, presumably due to the altered pattern of expression of mRNAs encoding individual nAChR subunits. The altered ion channel expression in these variants provides an avenue for analyzing Na channel and nAChR channel function, as well as for identifying mechanisms governing their expression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238418
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  • 4
    Electronic Resource
    Electronic Resource
    Aerobic diving limits of immature Weddell seals (1983)
    Springer
    Journal of comparative physiology 151 (1983), S. 171-174 
    Details
    ISSN: 1432-136X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary 1. Consistent with previous studies on adult seals, post-dive blood lactic acid (LA) concentrations in immature Weddell seals did not increase above resting levels after short voluntary dives (Fig. 1). 2. Following longer dives, peak blood LA values increased rapidly according to the duration of the dive (Fig. 1). 3. The peak post-dive blood LA concentration relative to dive duration demonstrate that there is a positive relationship between aerobic dive limit (ADL) and body size (Fig. 1 and 3). 4. The ADL for 130 to 145 kg seals was about 10 min, and it was 13 min for 185 to 205 kg seals (Fig. 1). 5. The calculation of the ADL from available oxygen stores correlates well with the lactate/endurance curve intercept, where peak post-dive LA concentration rises rapidly above resting levels as the dive duration increases in adult and immature animals (Table 2 and Fig. 3). 6. Of total dives, 4% of the dive durations exceeded the measured ADL in 130 to 145 kg seals and 8% in the 205 kg seal (Fig. 2). 7. Dive depths of immature seals did not exceed 315 m (Table 1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689915
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