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  • 1
    Electronic Resource
    Electronic Resource
    Mineral loss in cortical and trabecular bone during high-dose prednisone treatment (1984)
    Springer
    Calcified tissue international 36 (1984), S. 269-273 
    Details
    ISSN: 1432-0827
    Keywords: Bone loss (osteopenia) ; Calcium ; Corticosteroids (glucocorticosteroids) ; Fluoride ; Vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary To evaluate the effect of prednisone and triple treatment (sodium fluoride, calcium, and vitamin D) on trabecular and cortical bone serial bone mineral content (BMC) measurements were made at a metaphyseal (BMCD) and diaphyseal (BMCP) site on the forearm on 31 consecutive and previously bone-healthy patients scheduled for at least 24 weeks high-dose prednisone treatment. The patients were randomized into two further treatment groups: group I (n=16) received prednisone plus triple treatment and group II (n=15) received only prednisone. The two groups were similar with regard to age, sex, prednisone dose, and initial BMC. During 24 weeks treatment, BMCD (partially representing trabecular bone) and BMCP (mainly representing cortical bone) fell significantly and similarly, demonstrating that there is no preventive effect on bone mineral loss on the triple regimen. The BMC fall after 12 weeks was significantly more pronounced for metaphyseal (partially trabecular) than for diaphyseal (cortical) bone, whereas the values did not differ significantly after 24 weeks; this indicates a greater sensitivity to the hormone treatment of trabecular bone. In the entire group, the fall in BMC correlated positively with individual prednisone dose, significant at the diaphyseal site (r=0.39,P〈0.05), but not at the metaphyseal site (r=0.31, P=0.08). It is concluded that corticosteroid-induced osteopenia is a diffuse bone disease which affects trabecular as well as cortical bone, suggesting that BMC measured on the forearm reflects changes in bone mineral at other locations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405329
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  • 2
    Electronic Resource
    Electronic Resource
    A whole-body radioactivity monitor for clinical use (1976)
    Springer
    Medical & biological engineering & computing 14 (1976), S. 461-464 
    Details
    ISSN: 1741-0444
    Keywords: Whole-body monitor ; Background index ; Spectrum stabiliser
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire Il s'agit d'un moniteur de radioactivité du corps intégral. Le moniteur a trois cristaux d'iodure de sodium (T1) mesurant 153 mm de diamètre et 102 mm d'épaisseur. Les détecteurs sont montés sur un chariot en acier, le balayage étant effectué effectué le long d'un axe longitudinal. L'appareil électronique comporte un stabilisateur de spectre qui a réduit au minimum le temps nécessaire au réglage des détecteurs. Grâce à l'indice de fond très faible du compteur, 00.202 compte/min par cm3, ainsi qu à la résolution spectrométrique de 7.1% pour40K, on peut prendre des mesures précises du potassium total du corps à partir de40K en moins de 30 minutes.
    Abstract: Zusammenfassung Es wird ein neues Überwachungsgerät für den ganzen Körper beschrieben, das für den klinischen Einsatz vorgesehen ist. Das Überwachungsgerät hat drei Natriumiodid-Kristalle (T1) von 153 mm Durchmesser und 102 mm Stärke. Die Strahlungs-empfänger sind auf einem Stahlwagen angebracht, und die Abtastung erfolgt über eine Längsachse. Die Elektronik enthält u.a. einen Spektrumsstabilisator, durch den die Zeit zur Einstellung der Strahlungsempfänger sehr reduziert wird. Durch den sehr geringen Störpegelindex des Zählers von 0.202 Zahlen/min pro cm3 sowie die Spektrometerauflösung von 8.1% für40K ergibt sich ein genaues Meßinstrument, das den Gesamt-Kaliumgehalt des Körpers ab40K innerhalb von 30 Minuten messen kann.
    Notes: Abstract A new whole-body monitor for clinical use is described. The monitor has three sodium iodide (TI) crystals, 153 mm in diameter and 102 mm thick. The detectors are mounted on a steel carriage, and scanning is performed along a longitudinal axis. The electronic equipment includes a spectrum stabiliser, which has minimised the time used for adjustment of the detectors. The very low background index of the counter of 0·202 counts/min per cm3, together with the spectrometric resolution of 7·1% for40K, permits precise measurements of total body potassium from40K within 30 min.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476125
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