ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The ‘syn’-1,3-diols 3,4 and 5 with a C7, C6, and C5 chain, respectively, were synthesized from methyl hydrogen 3-hydroxyglutarate (2; Schemes 1 and 2). The latter is available in (R)- and (S)-configuration. Octyl (3R)-4-chloro-3-hydroxybutanoate (17) is an alternative starting material for the preparation of 5 (Scheme 3.) The epoxide 20, derived from 5 in a one-pot reaction, is a versatile synthon, which selectively reacts with a great number of nucleophiles (Scheme 4).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19880710106
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