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  • 1
    Electronic Resource
    Electronic Resource
    Cooperative effects in simulated water (1979)
    [s.l.] : Nature Publishing Group
    Nature 282 (1979), S. 459-464 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Computer simulation calculations on liquid water, aqueous solutions and biological interfaces have been made almost universally assuming pair-additive interactions. Experimental and theoretical evidence implies this is a serious oversimplification. The development and testing of a different ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/282459a0
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  • 2
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    BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers (2013)
    Oxford University Press
    Details
    Publication Date: 2013-10-08
    Description: Here, we show for the first time, that the familial breast/ovarian cancer susceptibility gene BRCA1 activates the Notch pathway in breast cells by transcriptional upregulation of Notch ligands and receptors in both normal and cancer cells. We demonstrate through chromatin immunoprecipitation assays that BRCA1 is localized to a conserved intronic enhancer region within the Notch ligand Jagged-1 (JAG1) gene, an event requiring Np63. We propose that this BRCA1/Np63-mediated induction of JAG1 may be important the regulation of breast stem/precursor cells, as knockdown of all three proteins resulted in increased tumoursphere growth and increased activity of stem cell markers such as Aldehyde Dehydrogenase 1 (ALDH1). Knockdown of Notch1 and JAG1 phenocopied BRCA1 knockdown resulting in the loss of Estrogen Receptor-α (ER-α) expression and other luminal markers. A Notch mimetic peptide could activate an ER-α promoter reporter in a BRCA1-dependent manner, whereas Notch inhibition using a -secretase inhibitor reversed this process. We demonstrate that inhibition of Notch signalling resulted in decreased sensitivity to the anti-estrogen drug Tamoxifen but increased expression of markers associated with basal-like breast cancer. Together, these findings suggest that BRCA1 transcriptional upregulation of Notch signalling is a key event in the normal differentiation process in breast tissue.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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    BRCA1 is a key regulator of breast differentiation through activation of Notch signalling with implications for anti-endocrine treatment of breast cancers (2013)
    Oxford University Press
    Details
    Publication Date: 2013-07-17
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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  • 4
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    Short-range order in different models of water (1981)
    International Union of Crystallography
    Details
    Publication Date: 1981-08-16
    Print ISSN: 0567-7394
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by International Union of Crystallography
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  • 5
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    Cooperative effects in simulated water (1979)
    Springer Nature
    Details
    Publication Date: 1979-11-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 6
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    X-Ray Amorphous Phases in Antarctica Dry Valley Soils: Insight into Aqueous Alteration Processes on Mars? (2015)
    In:  CASI
    Details
    Publication Date: 2019-07-19
    Description: The Chemistry and Mineralogy (CheMin) instrument onboard the Mars Curiosity rover has detected abundant amounts (approx. 25-30 weight percentage) of X-ray amorphous materials in a windblown deposit (Rocknest) and in a sedimentary mudstone (Cumberland and John Klein) in Gale crater, Mars. On Earth, X-ray amorphous components are common in soils and sediments, but usually not as abundant as detected in Gale crater. One hypothesis for the abundant X-ray amorphous materials on Mars is limited interaction of liquid water with surface materials, kinetically inhibiting maturation to more crystalline phases. The objective of this study was to characterize the chemistry and mineralogy of soils formed in the Antarctica Dry Valleys, one of the driest locations on Earth. Two soils were characterized from different elevations, including a low elevation, coastal, subxerous soil in Taylor Valley and a high elevation, ultraxerous soil in University Valley. A variety of techniques were used to characterize materials from each soil horizon, including Rietveld analysis of X-ray diffraction data. For Taylor Valley soil, the X-ray amorphous component ranged from about 4 weight percentage in the upper horizon to as high as 15 weight percentage in the lowest horizon just above the permafrost layer. Transmission electron microscopy indicated that the presence of short-range ordered (SRO) smectite was the most likely candidate for the X-ray amorphous materials in the Taylor Valley soils. The SRO smectite is likely an aqueous alteration product of mica inherited from granitic materials during glaciation of Taylor Valley. The drier University Valley soils had lower X-ray amorphous contents of about 5 weight percentage in the lowest horizon. The X-ray amorphous materials in University Valley are attributed to nanoparticles of TiO2 and possibly amorphous SiO2. The high abundance of X-ray amorphous materials in Taylor Valley is surprising for one of the driest places on Earth. These materials may have been physically and chemical altered during soil formation, however, the limited interaction with water and low temperatures may result in the formation of "immature" X-ray amorphous or SRO materials. Perhaps, a similar process contributes to the formation of the high content of X-ray amorphous materials detected on Mars.
    Keywords: Earth Resources and Remote Sensing; Lunar and Planetary Science and Exploration
    Type: JSC-CN-34194 , AGU 2015: Fall American Geophysical Union Meeting; Dec 14, 2015 - Dec 18, 2015; San Francisco, CA; United States
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  • 7
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    Composition and Petrology of HED Polymict Breccias: The Regolith of (4) Vesta (2012)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The polymict breccias of the howardite, eucrite and diogenite (HED) clan of meteorites preserve records of regolith processes that occur on Vesta, their putative home world. These breccias -- howardites, polymict eucrites and polymict diogenites -- are impact-engendered mixtures of diogenites and eucrites. The compositions of polymict breccias can be used to constrain the lithologic diversity of the vestan crust and the excavation depths of these materials. We have done petrological and compositional studies of multiple samples of 5 polymict eucrites and 28 howardites to investigate these issues. Older analyses were done on samples of approx 0.5 gram mass by INAA; newer analyses on samples of approx 5 gram mass by XRF and ICP-MS. We estimate the percentage of eucritic material (POEM) of polymict breccias by comparing their Al and/or Ca contents to those of average basaltic eucrite and diogenite. Our samples have POEM ranging from 28 to 98; adding two polymict diogenites from extends the range to POEM 10. One hypothesis is that ancient, well-mixed vestan regolith has POEM approx 67 and has a higher content of admixed impactor material. Several of our howardites have POEM of 59-74 (Al and/or Ca contents +/- 10% of POEM 67); about a third have Ni contents 〉300 micro g/g suggesting they contain 〉2% chondritic material (CM and/or CR). These may be regolithic howardites. Only one (LEW 85313) contains Ne dominated by a solar wind (SW) component. PCA 02066 is dominated by impact-melt material of polymict parentage and petrologically appears to be a mature regolith breccia, yet it does not contain SW-Ne. GRO 95602 falls within the POEM window, contains SW-Ne], yet has a Ni content of 193 micro g/g. Its petrologic characteristics suggest it was formed from immature regolith (no polymict breccia clasts; no glass). Trace element characteristics of the polymict breccias demonstrate the dominance of main-group eucrites as the basaltic component. Mixing diagrams of Zr, Nb, Ba, Hf and Ta with Al show no evidence for a significant contribution from Stannern-trend eucrites. An exception is polymict eucrite LEW 86001 (POEM 92), which is dominated by Stannern-trend basaltic debris. Howardite LAP 04838 (POEM 84) has higher incompatible trace concentrations than other polymict breccias (excluding LEW 86001), and either contains a Stannern-trend basaltic component, or has a significant contributions from evolved eucrites like Nuevo Laredo.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-CN-26598 , 75th Annual Meeting of the Meteoritcal Society meeting; Aug 12, 2012 - Aug 17, 2012; Cairns; Australia
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  • 8
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    In Situ Analysis of Orthopyroxene in Diogenites Using Laser Ablation ICP-MS (2012)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Howardites, eucrites and diogenites (HED) form a suit of igneous achondrite meteorites that are thought to have formed on a single asteroidal body. While there have been many different models proposed for the formation of the HED parent asteroid they can be generalized into two end member models. One is the magma ocean model (e.g. [1]) in which the entire HED parent body was continuously fractionated from a planet wide magma ocean with diogenites representing the lower crust and eucrites being upper crustal rocks. The second model hypothesizes that diogenites and eucrites were formed as a series of intrusions and/or extrusions of partial melts of a primitive proto-Vesta [2]. We use in situ trace element analysis together with major and minor element analysis to try and distinguish between these different hypotheses for the evolution of the HED parent body.
    Keywords: Geophysics
    Type: JSC-CN-25704 , 43rd Lunar and Planetary Science Conference; Mar 19, 2012 - Mar 23, 2012; The Woodlands, TX; United States
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  • 9
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    The Continuing Quest for "Regolithic" Howardites (2012)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The howardite, eucrite and diogenite (HED) meteorites likely originate from asteroid 4-Vesta, the first of two asteroids targeted by NASA's Dawn mission]. Howardites are polymict breccias dominantly composed of basaltic (eucrite) and orthopyroxenitic (diogenite) material. They are believed to originate from the surface of Vesta, and may represent the regolithic surface layer. Many howardites contain "regolith"-like features including fragmental breccias clasts, carbonaceous chondrite fragments and melt clasts (impact and volcanic). Though such features may relate to asteroid regolith formation processes, the exact regolithic nature of the howardite suite is not well defined.
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-CN-25699 , 43rd Lunar and Planetary Science Conference; Mar 19, 2012 - Mar 23, 2012; The Woodlands, TX; United States
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  • 10
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    In the Pursuit of Regolithic Howardites (2012)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The HED (Howardite, Eucrite and Diogenite) meteorite clan likely originate from the asteroid 4-Vesta [1]. Howardites (polymict breccias of eucritic and diogenitic material) are believed to originate from the vestan surface, and many contain regolith-like features (impact and/or melt clasts, fragmental breccia clasts, carbonaceous chondrite fragments), which may relate to regolith-formation processes. Noble gas analysis can help determine true regolithic nature, as Solar Wind (SW) is im-planted into grains at the upper-surfaces of solar system bodies lacking an atmosphere or magnetic field. Howardites from Ves-ta s true regolith would thus show evidence for SW components. Thus far, we have identified 5 regolithic howardites: LEW 85313; MET 00423; PRA 04401; SCO 06040 and EET 87513; based on our noble gas analyses, with the latter 3 showing some evidence for a planetary(+SW) component, likely related to CM-like material present in the assemblage [2-5]. However, we did not find a good correlation between SW content and other petro-logic regolithic features. Nor did we find an obvious correlation between SW and high siderophile element contents (Ni greater than 300 micrograms/gram), or an Al2O3 range of 8-9 wt% and eucrite/diogenite (E/D) ratio of 2:1 as suggested by [6] to be further regolith indicators. Here, we report our latest noble gas data for two howardites GRO 95535, GRO 95602 and a polymict eucrite EET 87518 in continuing research aimed at better understanding the vestan regolith. Results: Noble gas analysis was performed on an MAP 215-50 noble gas mass spectrometer using furnace step-heating. Our results, shown in Table 1, are compared with SW- (LEW 85313) and planetary-dominated (PRA 04401 ~60% CM) howardites [2]. EET 87518 is dominated by cosmogenic components. By comparison, both howardites show strong evidence for SW, with total Ne-20/Ne-22 ~8.7-8.8 (SW: Ne-20/Ne-22 13.78 [7]), and identical release patterns to our other CM-poor SW-rich samples. This suggests that these samples are from the vestan regolith. As they have lower Ni contents than suggested by [6], this further illustrates that these parameters may show some bias [2].
    Keywords: Lunar and Planetary Science and Exploration
    Type: JSC-CN-26603 , 75th Annual Meeting of the Meteoritcal Society; Aug 12, 2012 - Aug 17, 2012; Cairns; Australia
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