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  • 1
    Electronic Resource
    Electronic Resource
    Preserved Close Linkage Between the Genes Encoding Troponin I and Troponin T, Reflecting an Evolution of Adapter Proteins Coupling the Ca2+ Signaling of Contractility (1999)
    Springer
    Journal of molecular evolution 49 (1999), S. 780-788 
    Details
    ISSN: 1432-1432
    Keywords: Key words: Troponin — Muscle contraction — Cell motility — Calcium signal transduction — E-C coupling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Ca2+-regulated motility is essential to numerous cellular functions, including muscle contraction. Systems with troponin C, myosin light chain, or calmodulin as the Ca2+ receptor have evolved in striated muscle and other types of cells to transduce the cytoplasm Ca2+ signals into allosteric conformational changes of contractile proteins. While these Ca2+ receptors are homologous proteins, their coupling to the responding elements is quite different in various cell types. The Ca2+ regulatory system in vertebrate striated muscle represents a highly specialized such signal transduction pathway consisting of the troponin complex and tropomyosin associated with the actin filament. To understand the molecular mechanism in the Ca2+ regulation of muscle contraction and cell motility, we have revealed a preserved ancestral close linkage between the genes encoding two of the troponin subunits, troponin I and troponin T, in the genome of mouse. The data suggest that the troponin I and troponin T genes may have originated from a single locus and evolved in parallel to encode a striated muscle-specific adapter to couple the Ca2+ receptor, troponin C, to the actin–myosin contractile machinery. This hypothesis views the three troponin subunits as two structure–function domains: the Ca2+ receptor and the signal transducing adapter. This model may help to further our understanding of the Ca2+ regulation of muscle contraction and the structure–function relationship of other potential adapter proteins which are converged to constitute the Ca2+ signal transduction pathways governing nonmuscle cell motility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006600
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  • 2
    Electronic Resource
    Electronic Resource
    The Effects of Thermo-Mechanical Treatment on the Properties of 2519 Aluminum Alloy (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 546-549 (May 2007), p. 1027-1032 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A procedure of thermo-mechanical treatment (TMT) was carried out to 2519 aluminumalloy to improve its properties. The influences of cold deformation ratio, ageing temperature andageing time of the TMT on the mechanical properties and electrochemical corrosion resistance of thisalloy were investigated. The results show that after TMT the tensile strength of 2519 aluminum alloycan be improved obviously but its electrochemical corrosion resistance decreases slightly. Theoptimum processing parameters of the TMT for 2519 aluminum alloy can be described as: solidsolution at 530°Cfor 0.5h, then cold deform with a ratio of 15% followed by aging at 150°C for10h
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.546-549.1027.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    A brain-specific activator of cyclin-dependent kinase 5 (1994)
    [s.l.] : Nature Publishing Group
    Nature 371 (1994), S. 423-426 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The catalytic subunit of the neuronal Cdc2-like kinase has been isolated previously9'11 13. Using the polymerase chain reaction (PCR), we have now cloned the p25 regulatory subunit by 3'- and 5'-RACE (rapid amplification of cDNA ends). The longest PCR fragment isolated did not extend to an ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/371423a0
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  • 4
    Electronic Resource
    Electronic Resource
    Spectrophotometric study on the quaternary complex of titanium (IV) with secondary ligands, 2,6,7-trihydroxylphenyl-fluorone derivatives and cetyltrimethylammonium bromide (1992)
    Springer
    Microchimica acta 108 (1992), S. 79-91 
    Details
    ISSN: 1436-5073
    Keywords: titanium determination ; 2,6,7-trihydroxylphenyl-fluorone ; nitrilotriacetic acid ; spectrophotometry ; cationic surfactant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The new color reactions of titanium (IV) with six 2,6,7-trihydroxyl-9-phenylsubstituted-3-fluorone derivatives (THPF) have been studied in the presence of nitrilotriacetic acid (NTA) and cetyltrimethylammonium bromide (CTMAB). The effects of secondary ligands such as NTA, ascorbic acid, hydroxylamine and mandelic acid on the ternary complex of titanium (IV) have been reported. It was found that the system of titanium (IV)-2,6,7-trihydroxyl-9-(2′,4′-dichlorophenyl)-3-fluorone (DCPF)-NTA-CTMAB quaternary complex is the most sensitive in these systems studied. The apparent molar absorptivity of the complex at 576 nm is 1.9 × 105 1·mol−1·cm−1. The stoichiometric ratio of the Ti (IV)-NTA-DCPF-CTMAB complex is estimated to be 1 ∶ 1 ∶ 3 ∶ 3. The proposed method proves to be satisfactory for the direct determination of titanium in alloy steels, silicate minerals and aluminium alloys. The method is highly sensitive and selective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01240374
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  • 5
    Electronic Resource
    Electronic Resource
    Nebulin is a full-length template of actin filaments in the skeletal muscle sarcomere: an immunoelectron microscopic study of its orientation and span with site-specific monoclonal antibodies (1993)
    Springer
    Journal of muscle research and cell motility 14 (1993), S. 476-483 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nebulin, a giant myofibrillar protein with size variants from 700 to 900 kDa in various skeletal muscles, has been proposed to constitute a set of inextensible filaments anchored at the Z-line and coextensive with actin filaments. To elucidate the architectural organization of this fourth set of myofilaments in the skeletal muscle sarcomere, we performed immunoelectron microscopic localization of epitope profiles of a number of site-specific monoclonal antibodies against cloned human nebulin fragments of known sequence loci. Monoclonal antibody N113, which is directed to fragment ND8 at approximately 300 residues away from the C-terminus, labelled the edges of Z-lines in both human quadriceps muscle and rabbit psoas muscle. Monoclonal antibody N101, which is directed to fragment NB5 near the N-terminal side, is localized to a single locus at 0.89 μm from the Z-line in human quadriceps muscle and 0.80μm from the Z-line in rabbit psoas muscle. Additionally, monoclonal antibody N109, which is directed to fragment NA3 on the carboxy side of the adjacent fragment NB5, is localized at 0.76 μm away from the Z-line in rabbit psoas muscle. This one-to-one correspondence between epitope loci and sequence loci demonstrates that a single nebulin polypeptide spans the length of the thin filament with its C-terminus anchored at the Z-line. The epitope spacings of site-specific antibodies are consistent with the notion that the nebulin filament is uniform in mass density along its length. We conclude that the thin filament, as defined morphologically by electron microscopy, is a composite filament of the conventional actin thin filament (actin/tropomyosin/troponin) and coextensible nebulin polypeptides which act as full-length molecular templates that regulate or stabilize colaterally the actin filament in the skeletal muscle sarcomere.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00297210
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  • 6
    Electronic Resource
    Electronic Resource
    Regulatory properties of neuronal cdc2-like kinase (1995)
    Springer
    Molecular and cellular biochemistry 149-150 (1995), S. 35-39 
    Details
    ISSN: 1573-4919
    Keywords: neuronal cdc2-like kinase ; cdk5 ; regulatory subunit ; neurofilament proteins ; tau ; Alzheimer disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Neuronal cdc2-like kinase, nclk, is a heterodimer of cyclin dependent protein kinase 5, cdk5, and a 25 kDa subunit derived from a novel, neuron-specific, 35 kDa protein: p35. The characterization and regulation of nclk will be summarized in this minireview. The activity of nclk appears to be governed by highly complex regulatory mechanisms including protein-protien interaction, protein phosphorylation and isoforms. The histone H1 kinase activity of nclk is absolutely dependent of the interaction between the 25 kDa subunit and the catalytic subunit, cdk5. In addition, nclk interacts with other cellular proteins to form macromolecular complexes. The kinase activity of nclk is inhibitedin vitro by the phosphorylation reactions of a weel-like protein tyrosine kinase and a protein serine/threonine kinase from bovine thymus. Northern blot analysis has revealed the existence of two populations of p35 mRNA of 2 and 4 kb. A novel cDNA encoding a p35 homologous protein has been obtained from a human hippocampus library.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01076561
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  • 7
    Electronic Resource
    Electronic Resource
    Gravity-Driven reactive coating flow down an inclined plane (1994)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 40 (1994), S. 2-10 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The coating flow of a reactive fluid on an inclined plane is studied. The fluid viscosity steadily increases due to a sustained cross-linking reaction. Using well-known long wave approximations and a simple kinetic relation, we find that the linear stability of a uniform coating is affected not only by the inclination angle but also by the reaction order. In the weakly nonlinear limit, a generalized Kuramoto-Sivashinsky (K-S) equation is derived. Two interesting cases are identified in the limit of creeping flow. One is when surface tension is moderate and a generalized Burger's equation results, and the other is when the surface tension is large and the traditional K-S equation is recovered when the inclination angle is greater than 90°. The solution in this case represents a shock-like traveling wave down the incline and it appears to be unique for reacting coating flows.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690400103
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  • 8
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    CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis (2015)
    Springer Nature
    Details
    Publication Date: 2015-05-14
    Description: Article Dendritic cells are critical for initiation of immune responses and for induction of tolerance. Here the authors show that deletion of survival factor c-flip in CD11c-expressing cells subset perturbs CD8a + dendritic cell, NK and macrophage pools, and leads to development of autoimmune arthritis. Nature Communications doi: 10.1038/ncomms8086 Authors: Qi-Quan Huang, Harris Perlman, Robert Birkett, Renee Doyle, Deyu Fang, G. Kenneth Haines, William Robinson, Syamal Datta, Zan Huang, Quan-Zhen Li, Hyewon Phee, Richard M. Pope
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
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    Influence of Abyssal Mixing on the Multi-Layer Circulation in the South China Sea (2019)
    American Meteorological Society (AMS)
    Details
    Publication Date: 2019
    Description: Journal of Physical Oceanography, Ahead of Print. 〈br/〉
    Print ISSN: 0022-3670
    Electronic ISSN: 1520-0485
    Topics: Geosciences , Physics
    Published by American Meteorological Society (AMS)
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  • 10
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    Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Electronic ISSN: 2399-3642
    Topics: Biology
    Published by Springer Nature
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