ISSN:
0899-0042
Keywords:
chiral separation
;
chiral stationary phases
;
hydroxyphosphonates
;
chiroptical study
;
enantiomeric excess
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The enantiomers of 17 α-hydroxybenzylphosphonate diethylesters containing para, or ortho substituents or other aromatic rings (1-naphthyl, 2-naphthyl, and 2-thienyl) have been successfully separated by HPLC on a Whelk-O 1 chiral stationary phase which is superior to other CSPs. The effect of the substituents, particularly halogens, on the enantioselectivity was investigated and related to a chiral recognition model. The absolute configurations of 4-methyl and 2-methyl substituted α-hydroxybenzylphosphonates were obtained by measurement of the circular dichroism spectra of the isolated enantiomers. Chirality 10:100-105, 1998. © 1998 Wiley-Liss,Inc.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chir.17
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