ISSN:
1573-4838
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Technology
Notes:
Abstract The synthesis and application of hydrogel biospecific sorbents with immobilized physiologically active substances for creation of bio- and blood-compatible polymeric materials are given and discussed. The chemical nature and structure of affinic ligand, its availability and distribution in the matrix determine the action efficiency of these sorbents. A high blood-compatibility of polymers can be reached by chemical modification with several physiologically active substances acting at the different steps of thromboformation. The complex biotissue chemical modification permits the reduction of calcium and phosphorus accumulation inin vivo experiments by 10–100 times, compared with the control.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00703367
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