ISSN:
1573-2878
Keywords:
Compartment models
;
duality theory
;
convex programming
;
impulsive control
Source:
Springer Online Journal Archives 1860-2000
Topics:
Mathematics
Notes:
Abstract Optimal impulsive control of systems arising from linear compartment models for drug distribution in the human body is considered. A system of linear, time-invariant, homogeneous differential equations is given along with a set of continuous constraints on state and control. The object is to develop a constructive algorithm for the computation of the optimal control relative to a convex cost functional. It is first shown that under suitable hypotheses, satisfying the continuous constraints is equivalent to satisfying the constraints at a finite set of abstractly definedcritical points. Once these critical points have been determined, the solution of the optimal control problem is found as the solution of a finite-dimensional convex programming problem. The set of critical points can often be determineda priori solely from the qualitative behavior of the solutions of the system. A class of such problems, generalizing the so-calledplateau effect, is considered in detail. It is shown that the solution achieving the plateau effect is indeed optimal in certain cases. In a subsequent paper, an iterative algorithm will be given for the solution of these problems when the critical points cannot all be determineda priori.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00932661
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