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  • 1
    Electronic Resource
    Electronic Resource
    Polysome metabolism in protein synthesis mutants of yeast (1974)
    Springer
    Molecular genetics and genomics 129 (1974), S. 189-200 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The size distributions of polysomes are examined in Saccharomyces cerevisiae strain A364A and in temperature sensitive mutants of this strain which are defective in several aspects of protein and RNA synthesis at the restrictive temperature, 36° C. The results indicate that the nature of the molecular defect is reflected in changes in the polysome pattern at 36° C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00267912
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  • 2
    Electronic Resource
    Electronic Resource
    Yeast mutant, rna1, affects the entry into polysomes of ribosomal RNA as well as messenger RNA (1978)
    Springer
    Molecular genetics and genomics 162 (1978), S. 319-322 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The entry of newly labeled ribosomal subunits and mRNA into polysomes was examined in the yeast mutant rna1. The entry of both types of RNA into polysomes is inhibited rapidly at the restrictive temperature. Analysis of the labeling of the ATP pool and the kinetics of synthesis and processing of mRNA at the restrictive temperature leads to the conclusion that the primary defect in the mutant affects transport of both ribosomes and messenger across the nuclear membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00268857
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  • 3
    Electronic Resource
    Electronic Resource
    Heat shock causes the collapse of the intermediate filament cytoskeleton in Drosophila embryos (1990)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 11 (1990), S. 270-279 
    Details
    ISSN: 0192-253X
    Keywords: Phenocopy ; developmental arrest ; heat lability ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Heat shock has a dramatic effect on the organization of the cytoplasm, causing the intermediate filament cytoskeleton to aggregate of the nucleus. This has previously been shown in cultured Drosophila and mammalian cells. In this paper we analyze the heat lability of the intermediate filament cytoskeleton in early Drosophila embryos by indirect immunofluorescence. At all stages of embryogenesis tested, the intermediatefilamentcytoskeleton, which is maternally provided, is severely disturbed by 30 min heat shock at 37°C. After the nuclei have migrated to the subcortical cytoplasm, it collapses around them. Nuclei in all heat-shocked embryos are considerably enlarged and become displaced. Embryos before cellular blastoderm stage, in which heat shock protein synthesis is not inducible, are irreversibly arrested in development by heat shock. Embryos at or after cellular blastoderm, which do synthesize heat shock proteins in response to stress, are also immediately arrested in development but continue development when returned to 25°C. We discuss the possibility that cytoplasmic events such as the intermediate filament cytoskeleton rearrangement may be involved in heat shock-mediated phenocopy induction.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020110405
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  • 4
    Electronic Resource
    Electronic Resource
    The recessive phenotype of forked can be uncovered by heat shock in Drosophila (1985)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 6 (1985), S. 93-100 
    Details
    ISSN: 0192-253X
    Keywords: heat shock ; phenocopy ; forked ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Heat shock uncovers the recessive forked phenotype when heterozygotes between f36a and wild-type are heated during sensitive periods in pupal development. We call the phenocopy of a mutant in such a heterozygote a heterocopy. The heterocopy in f36a/+ is virtually identical to the mutant phenotype; however, bristles on different parts of the body are affected during different sensitive periods. We discuss the hypothesis that the heat shock acts by affecting expression of the wild-type gene product corresponding to the mutant gene. The sensitive period for heterocopy induction in a specific tissue is proposed to correspond to the normal time of gene expression for the forked gene product in a particular tissue.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020060203
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  • 5
    Electronic Resource
    Electronic Resource
    Specific protection from phenocopy induction by heat shock (1979)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 1 (1979), S. 181-192 
    Details
    ISSN: 0192-253X
    Keywords: drosophila ; gene regulation ; heat shock ; protection phenocopies ; survival ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Mild heat treatments applied to whole animals or cell cultures of Drosophila prior to lethal heat shocks result in increased survival and protection against phenocopy induction. The optimal condition for the preliminary mild heat treatment is that which induces the synthesis of heat-shock proteins but does not turn off the protein synthesis that is in progress. Recovery of protein synthesis but not RNA synthesis following a drastic heat shock is much enhanced by the pretreatments. The results suggest that the protection for survival and against phenocopy induction is due to storage of messenger RNA.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020010206
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  • 6
    Electronic Resource
    Electronic Resource
    Effects of heat shock on protein processing and turnover in developing Drosophila wings (1989)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 10 (1989), S. 11-15 
    Details
    ISSN: 0192-253X
    Keywords: Phenocopies ; Proteolysis ; Protein stability ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Developmental defects called phenocopies can be induced by heating Drosophila melanogaster pupae at specific developmental stages. The induction of the defects is thought to be a result of interference with gene expression at some level (Petersen and Mitchell, Dev Biol 1987; 121:335-341, 1987). Here we look at protein turnover in developing 52-hour wings and at the effect of heat on the proteolytic processing of three proteins that normally turn over rapidly. The effect of the heat treatment itself on the turnover of each protein is different. However, all of the proteins appear to be stabilized at 25°C during recovery from severe heat shocks.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020100103
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  • 7
    Electronic Resource
    Electronic Resource
    Stages of cell hair construction in Drosophila (1990)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 11 (1990), S. 133-140 
    Details
    ISSN: 0192-253X
    Keywords: Morphogenesis ; heat shock ; phenocopies ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The construction of cell hairs (trichomes) on the wings of Drosophila occurs in synchrony on 30,000 cells over a period of about 20 hr. Changes in both morphology and patterns of protein synthesis occur rapidly during this time period. In this report we describe the use of stressinduced (heat shock) abnormalities in morphogenesis to provide further details on the stepwise processes of differentiation within single wing cells. A cartoon summary of the overall process and a discussion of some possible mechanisms is included.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020110203
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  • 8
    Electronic Resource
    Electronic Resource
    Developmental abnormalities in Drosophila induced by heat shock (1982)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 3 (1982), S. 91-102 
    Details
    ISSN: 0192-253X
    Keywords: hyperthermia ; heat shock ; phenocopy ; teratogenesis ; morphogenesis ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have for some years been making use of phenocopies in Drosophila, as induced by heat shock, as tools for studies of the molecular events in morphogenesis [18, 21, 22]. In this paper, we have brought together some accumulated information on the conditions for phenocopy production, on a temporal sequence of sensitivity to induction, and on the nature of many of the morphogenetic abnormalities that can be induced. In general, the induction of phenocopies by heat shock requires conditions drastic enough to turn off transcriptional activities but not extreme enough to prevent recovery. This situation is most easily achieved in pupal stages where heat resistance is high, but even in this range, resistance varies with the stage of development.The phenocopies described resemble, for the most part, mutants that affect structures derived from epithelial differentiation or muscle development.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020030202
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  • 9
    Electronic Resource
    Electronic Resource
    Stage-specific regulation of actin genes in Drosophila wing cells (1984)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 5 (1984), S. 219-225 
    Details
    ISSN: 0192-253X
    Keywords: actin ; gene regulation ; development ; Drosophila ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Extreme and rapid changes in the synthesis of messenger RNAs and proteins accompany differentiation in wing tissues of Drosophila. Of the six actin genes, at least three are expressed in wing cells, some during the most extreme changes in cell shape. However, different messages of the set appear, decay, and reappear on a regulated temporal program. These results show that actin expression is stage-specific in a single cell type.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020050405
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  • 10
    Electronic Resource
    Electronic Resource
    Epithelial differentiation in Drosophila pupae (1989)
    Chichester [u.a.] : Wiley-Blackwell
    Developmental Genetics 10 (1989), S. 42-52 
    Details
    ISSN: 0192-253X
    Keywords: Cuticulin ; Integument proteins ; Hair construction ; Wing differentiation ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The construction of cell hairs on the wings in developing pupae of Drosophila provides a unique system for studies of the regulation of differentiation in the absence of cell division. Early steps in hair construction are the extrusion of cell hairs and the deposition of the external impervious layer called “cuticulin.” Some properties of six of the most abundant proteins that are present during the early stages of hair construction are described. These proteins make up about 40% of the total protein of the preparation.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/dvg.1020100107
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