ISSN:
1352-8661
Keywords:
two-dimensional spectroscopic imaging
;
magnetic resonance spectroscopy
;
quantification methods
;
nonlinear least-square fitting
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
,
Physics
Notes:
Abstract Five protocols were tested for quantification onin vivo two-dimensional spectroscopic imaging datasets. The datasets are duplo measurements from three individuals. The peaks forN-acetyl aspartate, creatines, and cholines were quantified. The first of the protocols is conventional integration of a selected interval around the peak. The others are various implementations of a Gauss-Newton-based least-squares time-domain fitting algorithm. Fitting a half-echo (free-induction decay curve, FID) to a full echo was compared; this was combined with or without filtering out the water signal using the Lanczos-Hankel singular-value decomposition (LHSVD). It appears that conventional integration yields consistent and accurate results in comparison to the fitting methods. The combination of LHSVD and echo fitting performs equally well; advantages and disadvantages are discussed. The protocols using FID fitting perform poorly with these experimental datasets.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01771701
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