ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
Data presented here address the question of whether T lymphocyte recognition of Mis determinants is MHC restricted. Using isolated T cell blasts from primary MLCs involving H-2-identical, Mls-disparate strain combinations as responding cell populations in secondary MLCs, and measuring their responses against fresh stimulating cells from different strains, has permitted the study of reactions towards Mis determinants in the presence of MHC antigenic differences. Results strongly suggest that recognition of Mlsc (Mls-2 locus) determinants is H-2 restricted. In contrast, there is still little evidence that the recognition of Mlsa (Mls-1 locus) determinants is H-2 restricted. Furthermore, data are also presented which refute the notion that different H-2 haplotypes possess different abilities to present Mlsa determinants to responding T cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1988.tb00410.x
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