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  • 1
    Electronic Resource
    Electronic Resource
    Studies on the Pseudomonas aeruginosa PAO1 bacteriophage receptors (1983)
    Springer
    Archives of microbiology 135 (1983), S. 155-157 
    Details
    ISSN: 1432-072X
    Keywords: Pseudomonas aeruginosa ; PAO1 ; Phage PIK ; Receptor ; Lipopolysacharide ; Lipopolysaccharide inactivation by sugars
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Receptor for phage PIK specific for Pseudomonas aeruginosa strain PAO1 was studied. Phage PIK was strongly inactivated by lipopolysaccharide (LPS)_in vitro, exhibiting a PhI50 of 4.8 μg/ml. Further it was noted that this inactivation by LPS was reduced to 50% by several mono- and disaccharides when tested in vitro. d-glucosamine, d-mannose and l-rhamnose were found to be most effective at the concentration of 0.045 M, 0.25 M and 0.35 M respectively. This suggests the possibility that phage PIK receptor in LPS contains d-mannose, l-rhamnose and d-glucosamine. Either one of the former two could be located at a terminal position alpha-linked to the adjacent residue or located internally in the polysaccharide chain linked through its C-4 position. A theoretical approach to the interpretation of phage cell interaction was also investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408026
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  • 2
    Electronic Resource
    Electronic Resource
    The influence of free fatty acids on valproic acid plasma protein binding during fasting in normal humans (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 343-347 
    Details
    ISSN: 1432-1041
    Keywords: valproic acid ; fatty acids ; plasma protein binding ; pharmacokinetics ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of physiologic variations of free fatty acid levels on in vivo valproic acid plasma protein binding was studied in 6 healthy adult subjects. 14 blood samples were taken during a 12-h dosing interval at steady state while in a fed condition and also during a 27 h fast. Free fraction and total valproate concentration were determined by equilibrium dialysis and GLC, respectively. Free fatty acid levels were determined from both fresh samples and samples incubated at 37°C for 12 h, the latter in order to simulate equilibrium dialysis conditions. Fasting resulted in increased serum free fatty acid levels in all subjects, ranging from 34–182% (p〈0.01). Incubation also caused free fatty acid levels to rise, more so in fed samples (50–87%,p〈0.01) than in fasting samples (10–50%,p〈0.01). Fasting resulted in a 9% increase in the mean free fraction for all subjects combined (p〈0.01). Regression analysis of 180 sets of values for free fraction, total valproate concentration and free fatty acid level suggested that valproate concentration accounts for 17% and free fatty acid level for 37% of the variation in free fraction. Mean clearance was unchanged by fasting despite an increased free fraction suggesting decreased intrinsic clearance (i.e. decreased metabolism) of valproate under these conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613618
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  • 3
    Electronic Resource
    Electronic Resource
    Dose dependent pharmacokinetics of midazolam (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 91-95 
    Details
    ISSN: 1432-1041
    Keywords: midazolam ; 1-hydroxymethylmidazolam ; pharmacokinetics ; dose proportionality ; benzodiazepine ; healthy volunteers ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of midazolam and 1-hydroxymethylmidazolam were investigated following oral administration of 7.5, 15 and 30 mg doses of midazolam in solution to 12 healthy subjects. Compared to the 7.5 mg dose, the Cmax and AUC parameters of both midazolam and 1-hydroxymethylmidazolam increased proportionally after the 15 mg dose and more than proportionally after the 30 mg dose. The t1/2 for midazolam remained relatively constant between the 7.5 and 15 mg doses whereas it increased slightly but significantly after the 30 mg dose. These data indicated that the pharmacokinetics of midazolam and 1-hydroxymethylmidazolam were linear between the 7.5 and 15 mg oral dose range. However, after the 30 mg dose, the systemic availability of midazolam and the AUC for 1-hydroxymethylmidazolam appeared to be greater than that anticipated from the lower doses, possibly due to saturation of midazolam first-pass metabolism. This ist not expected to have any clinical significance under the conditions of therapeutic use.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547375
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  • 4
    Electronic Resource
    Electronic Resource
    Ceftriaxone pharmacokinetics following multiple intramuscular dosing (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 109-112 
    Details
    ISSN: 1432-1041
    Keywords: ceftriaxone ; intramuscular ; pharmacokinetics ; steady-state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The steady-state pharmacokinetics and tolerance of ceftriaxone after multiple i.m. doses of 0.5 and 1 g q12 h for 3.5 days were investigated in 12 healthy, adult volunteers. Ceftriaxone was rapidly absorbed after i.m. administration with mean peak times ranging from 1.3 to 1.9 h. Steady-state plasma concentrations were apparent after the third dose of both dosage regimens, with trough plasma concentrations of 24±6 and 39±8 µg/ml (mean±SD) after the 0.5 and 1 g q12 h regimens, respectively. Multiple i.m. administrations of ceftriaxone did not alter its elimination half-life; however, small increases were observed in the plasma clearance and volume of distribution at the 1-g regimen. These increases were attributed to the non-linear binding of ceftriaxone to human plasma proteins, and are therapeutically unimportant. Ceftriaxone was well tolerated and serious or lasting adverse reactions were not encountered in the study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614206
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  • 5
    Electronic Resource
    Electronic Resource
    The CEPH consortium linkage map of human chromosome 1
    Amsterdam : Elsevier
    Genomics 9 (1991), S. 686-700 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0888-7543(91)90362-I
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of somatic mutations at human minisatellite loci in tumors and cell lines
    Amsterdam : Elsevier
    Genomics 4 (1989), S. 328-334 
    Details
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0888-7543(89)90338-8
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  • 7
    Electronic Resource
    Electronic Resource
    Slump blocks, intraformational conglomerates and associated erosional structures in Pennsylvanian fluvial strata of eastern Canada (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 36 (1989), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1989.tb00825.x
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  • 8
    Electronic Resource
    Electronic Resource
    An ornamented mudstone cavity, Boss Point Formation, Sackville, New Brunswick, Canada: evidence for mud intrusion and rheoplasis (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 37 (1990), S. 0 
    Details
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: An ornamented, dome-shaped cavity, partially filled with mudstone, 4 m in diameter at its circular base and 1 m in height occurs in fluvial sandstone of the Carboniferous Boss Point Formation near Sackville, New Brunswick, Canada. The cavity formed by differential weathering and erosion of the mudstone. Its origin is enigmatic though its size, shape and relationship to the underlying mudstone bed on which it rests suggest a diapiric origin for the mudstone that filled it. On the other hand, the ornamentation on the cavity surface includes flute moulds, suggesting an erosional origin for the domal structure.Of the four principal hypotheses for its origin the one preferred by the authors involves formation by diapiric intrusion of semi-fluid mud into liquefied sand, soon after deposition. The ornamentation on the cavity surface would have formed as part of the intrusion process. Structures akin to flute moulds have been produced experimentally in support of this interpretation by differential flow across a cement-mix-mud interface in a flow box and also by diapiric intrusion of mud in a soft cement mix. By analogy the flute moulds on the cavity surface could have been formed in the same way. By this interpretation, primary sedimentary processes need not be invoked to explain their occurrence on either this cavity surface or on the numerous other mudstone cavity surfaces that are ubiquitous in the Permo-Carboniferous of eastern Canada. Results of this study have important implications with respect to the potential diversity of origins of flute moulds in general.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3091.1990.tb01835.x
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  • 9
    Electronic Resource
    Electronic Resource
    On Taking India into the Twenty-First Century (New Economic Policy in India) (1987)
    Cambridge : Cambridge University Press
    Modern Asian studies 21 (1987), S. 209-231 
    Details
    ISSN: 0026-749X
    Source: Cambridge Journals Digital Archives
    Topics: Ethnic Sciences , History , Political Science , Economics
    Notes: On one of his many visits to India Kingsley Martin was once asked how he saw the prospects for Western Europe. His reply was that he was very optimistic as most of the leaders of Western Europe then were very old. If the transition from age to youth in national leadership is a sufficient basis for hope, we certainly have much to be grateful for in India. And our young Prime Minister has already struck a very responsive chord among large sections of Indian society by his promise of change. His mother had won the 1980 election on the promise of a ‘Government that works’. Mr Gandhi promised in 1984 a ‘Government that works faster’—thus heralding a promise of greater efficiency in general. When asked about the objective of his new Government, he used the now famous phrase that his objective was to take India into the twenty-first century. Taken at its face value, this was a rather vacuous phrase. It is not necessary for anyone to carry India, Atlas-like, into the twenty-first century. It would arrive at our doorstep in due course, as it will at everyone else's, and most probably without even a whimper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1017/S0026749X00013780
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of laboratory-prepared high-performance size-exclusion columns - Applications to food analysis
    Amsterdam : Elsevier
    Journal of Chromatography A 408 (1987), S. 115-127 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)81795-7
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