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  • 1
    Electronic Resource
    Electronic Resource
    Exclusion of ZFM1 as a candidate gene for multiple endocrine neoplasia type 1 (MEN1) (1997)
    Springer
    Human genetics 〈Berlin〉 99 (1997), S. 585-589 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The multiple endocrine neoplasia type 1 (MEN1) locus has been previously localised to 11q13 by combined tumour deletion mapping and linkage studies and a 3.8-cM region flanked by PYGM and D11S97 has been defined. The zinc finger in the MEN1 locus (ZFM1) gene, which has also been mapped to this region, represents a candidate gene for MEN1. The ZFM1 gene, which consists of 14 exons, encodes a 623-amino acid protein and exons 2, 8 and 12 encode the putative nuclear localisation signal, a zinc finger motif, and a proline-rich region, respectively. We have investigated these potentially functional regions for germ-line mutations by single-stranded conformational polymorphism (SSCP) analysis in 64 unrelated MEN1 patients. In addition, we performed DNA sequence analysis of all the 14 exons and 13 of the 26 exon-intron boundaries in four unrelated MEN1 patients. A 6-bp deletion that resulted in the loss of two proline residues at codons 479 and 480 in exon 12 was found in one MEN1 patient. However, this did not co-segregate with MEN1 in the family and represented a rare polymorphism. Analysis by SSCP, DNA sequencing, northern blotting, Southern blotting and pulsed field gel electrophoresis revealed no additional genetic abnormalities of ZFM1 in the other MEN1 patients. Thus, our results indicate that ZFM1 is excluded as a candidate gene for MEN1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050410
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  • 2
    Electronic Resource
    Electronic Resource
    Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11g13, and exclusion of μ-calpain as the multiple endocrine neoplasia type 1 gene (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 732-741 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Forty loci (16 polymorphic and 24 non-polymorphic) together with 23 cosmids isolated from a chromosome 11-specific library were used to construct a detailed genetic map of 11p13-11g13. The map was constructed by using a panel of 13 somatic cell hybrids that sub-divided this region into 19 intervals, a meiotic mapping panel of 33 multiple endocrine neoplasia type 1 (MEN1) families (134 affected and 269 unaffected members) and a mitotic mapping panel that was used to identify loss of heterozygosity in 38 MENI-associated tumours. The results defined the most likely order of the 16 loci as being: 11pter-D11S871(D11S288, D11S149)-11cen-CNTF-PGA-ROM1-D11S480-PYGM-SEA-D11S913-D115970-D11S97-D11S146-INT2-D11S971-D11S533-11gter. The meiotic mapping studies indicated that the most likely location of the MEN1 gene was in the interval flanked by PYGM and D11S97, and the results of mitotic mapping suggested a possible location of the MEN1 gene telomeric to SEA. Mapping studies of the gene encoding μ-calpain (CAPN1) located CAPN1 to llg13 and in the vicinity of the MEN1 locus. However, mutational analysis studies did not detect any germ-line CAPN1 DNA sequence abnormalities in 47 unrelated MEN1 patients and the results therefore exclude CAPN1 as the MEN1 gene. The detailed genetic map that has been constructed of the 11p13-11g13 region should facilitate the construction of a physical map and the identification of candidate genes for disease loci mapped to this region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02346182
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of the mouse proteasome regulator PA28b gene (1999)
    Springer
    Immunogenetics 49 (1999), S. 149-157 
    Details
    ISSN: 1432-1211
    Keywords: Key words Proteasome ; PA28 ; IFN ; MHC ; Class I
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The proteasome regulator PA28, which can be upregulated by IFN, is important in the modulation of proteasome activity. Since the proteasome has been implicated in the processing of the major histocompatibility complex (MHC) class I antigens, it was of interest to determine the regulatory elements of PA28 at the genomic level. Although PA28 has been found in different species, the gene layout on the chromosome was not determined. In this study, the genetic organization of mouse PA28b was characterized. Two copies of the PA28b gene, namely b1 and b2, were found by restriction fragment mapping and Southern hybridization. By fluorescence in situ hybridization, the location of the two PA28b genes was determined on chromosomes 11 and 14. PA28b1 has 11 exons, whereas PA28b2 has no introns and appears to be a nonfunctional pseudogene. The 5' promoter region of PA28b1 contains several transcriptional factor binding sites including two IFN responsive elements. The expression levels of PA28 and other gene products involved in MHC class I antigen presentation appear to be correlated in various tissues. Notably, PA28 is expressed at high levels in immunological tissues such as spleen and peripheral blood leukocytes. Taken together, PA28 seems to be co-regulated with other molecules involved in MHC class I antigen presentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050476
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  • 4
    Electronic Resource
    Electronic Resource
    Structures of inert atomic clusters and their magic numbers of geometry
    Amsterdam : Elsevier
    Physics Letters A 117 (1986), S. 115-119 
    Details
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9601(86)90015-0
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  • 5
    Electronic Resource
    Electronic Resource
    Use of modified nucleotides and uracil-DNA glycosylase (UNG) for the control of contamination in the PCR-based amplification of RNA
    Amsterdam : Elsevier
    Molecular and Cellular Probes 6 (1992), S. 251-256 
    Details
    ISSN: 0890-8508
    Keywords: Polymerase chain reaction ; contamination ; coxsackievirus ; viral diagnosis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0890-8508(92)90024-R
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  • 6
    Electronic Resource
    Electronic Resource
    Characteristics of β-phase PdAl Schottky contacts to n-GaAs (1995)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 78 (1995), S. 5739-5744 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Metallurgical and electrical properties of β-phase PdAl Schottky metallizations on n-GaAs after rapid thermal annealing for 20 s in the temperature range 500–1000 °C have been investigated using x-ray diffraction, transmission electron microscopy, Auger depth profiling, film resistivity, and current–voltage measurement. The Al-rich contacts were stable up to 900 °C whereas the Pd-rich contacts were less stable. The thermal stability of β-PdAl exhibited a sharp variation near the stoichiometric composition. The thermal stability of Pd-rich contacts decreased with increasing Pd composition, and the interfacial reaction after high-temperature annealing resulted in the formation of PdGa compound. The interface between Al-rich PdAl film and GaAs substrate remained quite sharp even after 900 °C anneal. The variation of interfacial stability at high temperatures between β-PdAl film and GaAs substrate is correlated to the compositional dependence of Al and Pd activities in PdAl within the β-phase region. The Schottky barrier heights of Al-rich PdAl contacts increased with annealing temperature. The barrier height enhancement in the annealed Al-rich contacts can be attributed to the thin AlxGa1−xAs layer formed at the interface. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.359635
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  • 7
    Electronic Resource
    Electronic Resource
    Mass transfer at the surface of a rotating cylinder
    Amsterdam : Elsevier
    Electrochimica Acta 26 (1981), S. 1345-1350 
    Details
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0013-4686(81)85120-1
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  • 8
    Electronic Resource
    Electronic Resource
    The kinetics of copper dissolution in acetonitrile-water copper(II) solutions
    Amsterdam : Elsevier
    Electrochimica Acta 20 (1975), S. 923-928 
    Details
    ISSN: 0013-4686
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0013-4686(75)85053-5
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  • 9
    Electronic Resource
    Electronic Resource
    Light-induced transient ion flux responses from maize leaves and their association with leaf growth and photosynthesis (2005)
    Oxford, UK : Blackwell Science Ltd
    Plant, cell & environment 28 (2005), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Net fluxes of H+, K+ and Ca2+ ions from maize (Zea mays L.) isolated leaf segments were measured non-invasively using ion-selective vibrating microelectrodes (the MIFE technique). Leaf segments were isolated from the blade base, containing actively elongating cells (basal segments), and from non-growing tip regions (tip segments). Ion fluxes were measured in response to bright white light (2600 µmol m−2 s−1) from either the leaf segments or the underlying mesophyll (after stripping the epidermis). Fluxes measured from the mesophyll showed no significant difference between basal and tip regions. In leaf segments (epidermis attached), light-induced flux kinetics of all ions measured (H+, Ca2+ and K+) were strikingly different between the two regions. It appears that epidermal K+ fluxes are required to drive leaf expansion growth, whereas in the mesophyll light-induced K+ flux changes are likely to play a charge balancing role. Light-stimulated Ca2+ influx was not directly attributable either to leaf photosynthetic performance or to leaf expansion growth. It is concluded that light-induced ion flux changes are associated with both leaf growth and photosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.2005.01270.x
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  • 10
    Electronic Resource
    Electronic Resource
    A subtype of the metabotropic glutamate receptor family in the olfactory system of Atlantic salmon
    Amsterdam : Elsevier
    FEBS Letters 354 (1994), S. 301-304 
    Details
    ISSN: 0014-5793
    Keywords: Atlantic salmon ; Glutamate ; Glutamate receptor ; Olfactory reception ; Phospholipase C
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(94)01149-4
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