ISSN:
1662-8985
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Porous calcium phosphate cement (CPC) scaffolds were successfully fabricated utilizingparticle-leaching method. Mesenchymal stem cells (MSCs) were cultured, expanded and seeded onthe scaffolds and the proliferation and differentiation of MSCs into osteoblastic phenotype weredetermined using MTT assay, ALP activity and ESEM. The results revealed that the CPC scaffoldswere biocompatible and had no negative effects on the MSCs in vitro. The in vivo biocompatibilityand osteogenicity of the scaffolds were investigated. Both pure scaffolds and MSCs/scaffoldconstructs were implanted in rabbit mandibles and studied histologically. The results showed thatCPC scaffolds exhibited good biocompatibility and osteoconductivity. Moreover, the introduction ofMSCs into the scaffolds dramatically enhanced the efficiency of new bone formation initially
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/41/transtech_doi~10.4028%252Fwww.scientific.net%252FAMR.47-50.1383.pdf
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