Publication Date:
1988-08-05
Description:
The N-methyl-D-aspartate (NMDA)-subtype of glutamate receptors has been well described as a result of the early appearance of NMDA antagonists, but no potent antagonist for the "non-NMDA" glutamate receptors has been available. Quinoxalinediones have now been found to be potent and competitive antagonists at non-NMDA glutamate receptors. These compounds will be useful in the determination of the structure-activity relations of quisqualate and kainate receptors and the role of such receptors in synaptic transmission in the mammalian brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Honore, T -- Davies, S N -- Drejer, J -- Fletcher, E J -- Jacobsen, P -- Lodge, D -- Nielsen, F E -- New York, N.Y. -- Science. 1988 Aug 5;241(4866):701-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ferroson Research Division, Soeborg, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2899909" target="_blank"〉PubMed〈/a〉
Keywords:
6-Cyano-7-nitroquinoxaline-2,3-dione
;
Action Potentials/drug effects
;
Animals
;
Aspartic Acid/analogs & derivatives/pharmacology
;
Binding, Competitive
;
Cell Membrane/metabolism
;
Cerebral Cortex/metabolism
;
Ibotenic Acid/analogs & derivatives/metabolism
;
Kainic Acid/metabolism
;
Ketamine/pharmacology
;
N-Methylaspartate
;
Neurons/physiology
;
Piperazines/metabolism
;
Quinoxalines/*pharmacology
;
Rats
;
Receptors, AMPA
;
Receptors, Drug/drug effects/metabolism
;
Receptors, Glutamate
;
Receptors, Kainic Acid
;
Receptors, N-Methyl-D-Aspartate
;
Receptors, Neurotransmitter/*drug effects/metabolism
;
Spinal Cord/physiology
;
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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