ISSN:
0749-1581
Keywords:
2,3-Dihydro-[1,5]benzoxazepin-4(5H)-ones
;
Conformation
;
Conformational energy differences
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H and 13C NMR spectra of 26 2,3-dihydro-[1,5]benzoxazepin-4(5H)-one derivatives and four thiono analogues are interpreted in terms of conformational equilibria. Similar to 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones, these compounds favour boat conformations of the seven-membered ring. In the lactams the conformational energy difference is very low, whereas a difference of 0.3 kcal mol-1 is recorded for the thionolactams, the conformation with the quasi-axial methyl group also being preferred.
Additional Material:
2 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260290309
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