Publication Date:
2017-02-14
Description:
Nature Reviews Microbiology 15, 169 (2017). doi:10.1038/nrmicro.2016.184 Authors: Sergey Shmakov, Aaron Smargon, David Scott, David Cox, Neena Pyzocha, Winston Yan, Omar O. Abudayyeh, Jonathan S. Gootenberg, Kira S. Makarova, Yuri I. Wolf, Konstantin Severinov, Feng Zhang & Eugene V. Koonin Class 2 CRISPR–Cas systems are characterized by effector modules that consist of a single multidomain protein, such as Cas9 or Cpf1. We designed a computational pipeline for the discovery of novel class 2 variants and used it to identify six new CRISPR–Cas subtypes. The diverse
Print ISSN:
1740-1526
Electronic ISSN:
1740-1534
Topics:
Biology
,
Medicine
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