ISSN:
1420-9071
Keywords:
Phaclofen
;
late inhibitory postsynaptic potential
;
cortex
;
GABA
;
baclofen
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The GABAB antagonist phaclofen blocked the postsynaptic hyperpolarization induced by the GABAB agonist baclofen during intracellular recordings in rat cortical cells. This effect appears to be selective since responses to GABAA agonists (muscimol, THIP), GABA, 5-HT and L-glutamate were unaffected. Phaclofen also blocked synaptically evoked late inhibitory postsynaptic potentials (late IPSP). These results suggest that the late IPSPs in cortical neurons are mediated by GABA acting on GABAB receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954857
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