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  • 1
    Electronic Resource
    Electronic Resource
    New Class of Lactic Acid Copolymers with Reactive and Hydrophilic Segments for Degradable Biomedical Materials (2003)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 426-432 (Aug. 2003), p. 3231-3236 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/07/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.426-432.3231.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation of oxidized 6-O-glycolchitosan, pH sensitivity of its aqueous solution and of its cross-linked hydrogel (1996)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 240 (1996), S. 263-273 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Chitosan and 6-O-glycolchitosan, a water-soluble chitosan derivative, were oxidized by periodate. In the case of chitosan, only degradation products were obtained. With 6-O-glycolchitosan, however, water-soluble amphoteric polyelectrolyte derivatives of chitosan having higher molecular weight were obtained. The oxidized 6-O-glycolchitosan (OX-GC) showed a pH sensitive change of viscosity in aqueous solution. Moreover, the OX-GC hydrogel, cross-linked with glutaraldehyde, showed a pH sensitive swelling behavior. The OX-GC showed biodegradation behavior by lysozyme after acetylation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1996.052400125
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  • 3
    Electronic Resource
    Electronic Resource
    Recruitment of enzyme activity in albumin by molecular imprinting (1996)
    Weinheim : Wiley-Blackwell
    Macromolecular Rapid Communications 17 (1996), S. 871-874 
    Details
    ISSN: 1022-1336
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The catalytic activity of bovine serum albumin (BSA) modified physically by molecular imprinting using transition-state analogue (TSA) as a template molecule was studied. The resultant imprinted serum albumin (Imp-BSA) showed the rate acceleration of dehydrofluorination reaction from (4R,4S)-4-fluoro-4-(4-nitrophenyl)butan-2-one (1) and followed the type of Michaelis-Menten reaction in ethyl acetate solution. The enzymatic activity of Imp-BSA was competitively inhibited by (4R,4S)-4-hydroxy-4-(4-nitrophenyl)butan-2-one (4).
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1996.030171205
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis of 6-O-carboxymethylchitin immobilizing doxorubicins through tetrapeptide spacer groups and its enzymatic release behavior of doxorubicin in vitro (1994)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 195 (1994), S. 2839-2853 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Chitin is a non-toxic biodegradable polysaccharide. 6-O-Carboxymethylchitin (CM-chitin) is a water-soluble chitin derivative. In order to provide a water-soluble macromolecular prodrug of doxorubicin (DXR) reducing the side-effects and exhibiting high antitumor activity, the fixation of DXRs to CM-chitin through covalent bonds was carried out. Especially, a lysosomally digestible tetrapeptide (Gly-Phe-Leu-Gly) was used as spacer groups between CM-chitin and DXRs. In this paper, two kinds of conjugates, CM-chitin/Gly-Phe-Leu-Gly/DXR conjugate 5 having lysosomally digestible tetrapeptide spacer groups and CM-chitin/C5/DXR conjugate 6 having pentamethylene spacer groups, were synthesized. The effect of introduction of the spacer groups on the release behavior of DXR from the conjugate was investigated. The conjugate 5 having tetrapeptide spacer groups showed a distinct increase in the release rate of DXR in the presence of the lysosomal enzyme cathepsin B at 37°C in vitro; however, the conjugate 6 did not show such specific release behavior.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1994.021950815
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  • 5
    Electronic Resource
    Electronic Resource
    Preparation of poly(lactic acid)-grafted amylose through the trimethylsilyl protection method and its biodegradation (1998)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 199 (1998), S. 2017-2022 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Biodegradable poly(lactic acid)-grafted amylose was synthesized using a trimethylsilyl (TMS) protection method. Tetrahydrofuran soluble, mostly trimethylsilyl protected amylose was prepared and reacted with potassium tert-butoxide to give the corresponding alkoxide. Poly(lactic acid)-grafted amyloses were obtained by ring-opening anionic polymerization of lactide using the polymeric alkoxides as initiators and subsequent removal of the TMS groups. The obtained graft copolymers show biodegradability and a microphase-separated morphology.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Synthesis of poly[(glycolic acid)-alt-(L-aspartic acid)] and its biodegradation behavior in vitro (1993)
    Basel : Wiley-Blackwell
    Die Makromolekulare Chemie, Rapid Communications 14 (1993), S. 825-831 
    Details
    ISSN: 0173-2803
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1993.030141215
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  • 7
    Electronic Resource
    Electronic Resource
    Synthesis and cytotoxic activity of doxorubicin bound to poly(α-malic acid) via ester or amide bonds (1992)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 193 (1992), S. 1881-1887 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Poly(α-malic acid) is of interest for the application as a biodegradable and bioadsorbable drug carrier, which has pendent reactive carboxylic acid groups. In order to provide a biodegradable macromolecular prodrug of doxorubicin (adriamycin, ADR), reducing the side-effects of ADR and exhibiting effective antitumor activity, ADR residues were covalently attched to poly(α-malic acid) via ester or amide bonds to give poly(α-malic acid)/ester/ADR conjugate 1 or poly(α-malic acid)/amide/ADR conjugate 2, respectively. The release rate of ADR from the poly(α-malic acid)/ester/ADR conjugate 1 was faster than that from the poly(α-malic acid)/amide/ADR conjugate 2 in buffer solution (pH 7,4) at 37°C. While the cytotoxic activity of poly(α-malic acid)/ester/ADR conjugate 1 is as strong as that of free ADR against p388D1 lymphocytic leukemia cells in vitro, the cytotoxic activity of poly(α-malic acid)/amide/ADR conjugate 2 is much lower.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1992.021930809
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  • 8
    Electronic Resource
    Electronic Resource
    Synthesis and characteristics of polydepsipeptide with pendant thiol groups (1998)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 36 (1998), S. 1283-1290 
    Details
    ISSN: 0887-624X
    Keywords: biodegradability ; oligo[(glycolic acid)-alt-(L-cysteine)] ; poly[(lactic acid)-depsipeptide] ; ring-opening polymerization ; pendant thiol group ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: To obtain water-soluble oligodepsipeptide with pendant thiol groups, the alternating co-oligomer [oligo(Glc-alt-Cys)], consisting of glycolic acid (Glc) and L-cysteine (Cys) residues as α-hydroxy acid and α-amino acid residues, respectively, was prepared by means of ring-opening homo-oligomerization of cyclo[Glc-Cys(MBzl)] and subsequent deprotection of methoxybenzyl groups. Moreover, to modify the properties of poly(lactic acid) [poly(LA)] and to introduce pendant thiol groups to poly(LA), the terpolymer of LA, Glc, and Cys {poly[LA-(Glc-Cys)]} was synthesized through ring-opening and copolymerization of L-lactide with the protected cyclodepsipeptide, cyclo[Glc-Cys(MBzl)] and subsequent deprotection of methoxybenzyl groups. By changing the mol fraction of (Glc-Cys) unit, the solubility, thermal transition, degradation behavior of the modified poly(LA), and the water contact angle of its film could be varied. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 1283-1290, 1998
    Additional Material: 1 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    Synthesis and enzymatic hydrolysis of lactic acid-depsipeptide copolymers with functionalized pendant groups (1997)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 35 (1997), S. 377-383 
    Details
    ISSN: 0887-624X
    Keywords: biodegradability ; poly(lactic acid) ; lactic acid-depsipeptide copolymer ; ring-opening copolymerization ; functionalized side-group ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Since poly(lactic acid) is the biodegradable polyester having low immunogenicity and good biocompatibility, it is utilized as a medical material. However, poly(lactic acid) is a water-insoluble crystalline polymer having no reactive side-chain group. Thus, the use of poly(lactic acid) is limited. To modify the properties of poly(lactic acid) and to introduce the functionalized pendant groups to poly(lactic acid), we synthesized two kinds of lactic acid-depsipeptide copolymers with reactive pendant groups, namely poly[LA-(Glc-Lys)] and poly[LA-(Glc-Asp)]. This was done through ring-opening copolymerizations of L-lactide with the corresponding protected cyclodepsipeptides, cyclo[Glc-Lys(Z)] and cyclo[Glc-Asp(OBzl)], and subsequent deprotection of benzyloxycarbonyl and benzyl groups, respectively. By changing the mole fraction of the corresponding depsipeptide units, the solubility, thermal transition and degradation behavior of the modified poly(lactic acid) could be varied. © 1997 John Wiley & Sons, Inc.
    Additional Material: 2 Ill.
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  • 10
    Electronic Resource
    Electronic Resource
    Synthesis and enzymatic hydrolysis of polydepsipeptides with functionalized pendant groups (1996)
    Weinheim : Wiley-Blackwell
    Macromolecular Chemistry and Physics 197 (1996), S. 1823-1833 
    Details
    ISSN: 1022-1352
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Water-soluble polydepsipeptides with functionalized side-chain groups, i.e., alternating copolymers, consisting of glycolic acid (Glc) and L-lysine (L-Lys), L-aspartic acid (L-Asp) or L-glutamic acid (L-Glu) residues as α-hydroxy acid and α-amino acid residues, respectively, were synthesized, and their biodegradation behavior was investigated. Three kinds of polydepsipeptides, poly(Glc-alt-Lys), poly(Glc-alt-Asp) and poly(Glc-alt-Glu), were synthesized by means of ring-opening polymerization of the corresponding cyclodepsipeptides and subsequent deprotection of benzyl and benzyloxycarbonyl groups. In order to estimate the main-chain cleavage behavior of polydepsipeptides with functionalized side-chain groups, the hydrolysis behavior of the obtained water-soluble polydepsipeptides was first investigated in phosphate buffer solution with or without an enzyme in vitro.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1996.021970604
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