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  • 1
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    Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury (2015)
    Springer Nature
    Details
    Publication Date: 2015-08-14
    Description: Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury Cell Death and Disease 6, e1854 (August 2015). doi:10.1038/cddis.2015.226 Authors: A Vercelli, S Biggi, A Sclip, I E Repetto, S Cimini, F Falleroni, S Tomasi, R Monti, N Tonna, F Morelli, V Grande, M Stravalaci, E Biasini, O Marin, F Bianco, D di Marino & T Borsello
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 2
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    Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface (2013)
    Springer Nature
    Details
    Publication Date: 2013-10-18
    Description: Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface Cell Death and Disease 4, e858 (October 2013). doi:10.1038/cddis.2013.385 Authors: B Pantic, E Trevisan, A Citta, M P Rigobello, O Marin, P Bernardi, S Salvatori & A Rasola
    Keywords: DMPKmitochondriaROScell deathhexokinaseSrc
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 3
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    Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-08-04
    Description: Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marin, O -- Yaron, A -- Bagri, A -- Tessier-Lavigne, M -- Rubenstein, J L -- K02MH01046-01/MH/NIMH NIH HHS/ -- R01DA12462/DA/NIDA NIH HHS/ -- R01MH49428-01/MH/NIMH NIH HHS/ -- R01MH51561-01A1/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2001 Aug 3;293(5531):872-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, Langley Porter Psychiatric Institute, University of California, San Francisco, CA 94143, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11486090" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Basal Ganglia/*cytology/embryology/metabolism ; COS Cells ; Cell Movement ; Cerebral Cortex/*cytology/embryology/metabolism ; Corpus Striatum/*cytology/embryology/metabolism ; Culture Techniques ; Glycoproteins/*metabolism ; Green Fluorescent Proteins ; Interneurons/metabolism/*physiology ; Ligands ; Luminescent Proteins/metabolism ; Membrane Proteins/*metabolism ; Mice ; Mice, Transgenic ; Mutation ; Nerve Tissue Proteins/genetics/*metabolism ; Neuropilin-1 ; Recombinant Proteins/metabolism ; Semaphorin-3A ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Journal club. A developmental neurobiologist looks at how damage induces cell birth in the adult brain (2010)
    Nature Publishing Group (NPG)
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    Publication Date: 2010-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marin, Oscar -- England -- Nature. 2010 May 27;465(7297):401. doi: 10.1038/465401e.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience, Sant Joan d'Alacant, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20505694" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-04-16
    Description: Schizophrenia is a complex disorder that interferes with the function of several brain systems required for cognition and normal social behaviour. Although the most notable clinical aspects of the disease only become apparent during late adolescence or early adulthood, many lines of evidence suggest that schizophrenia is a neurodevelopmental disorder with a strong genetic component. Several independent studies have identified neuregulin 1 (NRG1) and its receptor ERBB4 as important risk genes for schizophrenia, although their precise role in the disease process remains unknown. Here we show that Nrg1 and ErbB4 signalling controls the development of inhibitory circuitries in the mammalian cerebral cortex by cell-autonomously regulating the connectivity of specific GABA (gamma-aminobutyric acid)-containing interneurons. In contrast to the prevalent view, which supports a role for these genes in the formation and function of excitatory synapses between pyramidal cells, we found that ErbB4 expression in the mouse neocortex and hippocampus is largely confined to certain classes of interneurons. In particular, ErbB4 is expressed by many parvalbumin-expressing chandelier and basket cells, where it localizes to axon terminals and postsynaptic densities receiving glutamatergic input. Gain- and loss-of-function experiments, both in vitro and in vivo, demonstrate that ErbB4 cell-autonomously promotes the formation of axo-axonic inhibitory synapses over pyramidal cells, and that this function is probably mediated by Nrg1. In addition, ErbB4 expression in GABA-containing interneurons regulates the formation of excitatory synapses onto the dendrites of these cells. By contrast, ErbB4 is dispensable for excitatory transmission between pyramidal neurons. Altogether, our results indicate that Nrg1 and ErbB4 signalling is required for the wiring of GABA-mediated circuits in the postnatal cortex, providing a new perspective to the involvement of these genes in the aetiology of schizophrenia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fazzari, Pietro -- Paternain, Ana V -- Valiente, Manuel -- Pla, Ramon -- Lujan, Rafael -- Lloyd, Kent -- Lerma, Juan -- Marin, Oscar -- Rico, Beatriz -- England -- Nature. 2010 Apr 29;464(7293):1376-80. doi: 10.1038/nature08928. Epub 2010 Apr 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas & Universidad Miguel Hernandez, 03550 Sant Joan d'Alacant, Spain.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20393464" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cerebral Cortex/cytology/embryology/growth & development/*metabolism ; Dendrites/metabolism ; Embryo, Mammalian ; Excitatory Postsynaptic Potentials/genetics/physiology ; Female ; In Vitro Techniques ; Interneurons/*metabolism ; Mice ; Neural Inhibition/genetics/physiology ; Neural Pathways/*physiology ; Neuregulin-1/*metabolism ; Pyramidal Cells/metabolism ; Receptor, Epidermal Growth Factor/deficiency/genetics/*metabolism ; Receptor, ErbB-4 ; Schizophrenia/genetics/metabolism ; *Signal Transduction ; Synapses/metabolism ; gamma-Aminobutyric Acid/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    New neurons follow the flow of cerebrospinal fluid in the adult brain (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-01-18
    Description: In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawamoto, Kazunobu -- Wichterle, Hynek -- Gonzalez-Perez, Oscar -- Cholfin, Jeremy A -- Yamada, Masayuki -- Spassky, Nathalie -- Murcia, Noel S -- Garcia-Verdugo, Jose Manuel -- Marin, Oscar -- Rubenstein, John L R -- Tessier-Lavigne, Marc -- Okano, Hideyuki -- Alvarez-Buylla, Arturo -- HD 32116/HD/NICHD NIH HHS/ -- NS 28478/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 Feb 3;311(5761):629-32. Epub 2006 Jan 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA. sawamoto@sc.itc.keio.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16410488" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Tissue Transplantation ; Cell Movement ; Cell Polarity ; Cerebral Ventricles/cytology/physiology ; Cerebrospinal Fluid/*physiology ; Choroid Plexus/secretion ; Cilia/physiology ; Ependyma/cytology/*physiology ; Epithelial Cells/physiology ; Intercellular Signaling Peptides and Proteins ; Mice ; Nerve Tissue Proteins/cerebrospinal fluid ; Neurons/cytology/*physiology ; Olfactory Bulb/cytology/physiology ; Recombinant Fusion Proteins/cerebrospinal fluid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Brain development: The neuron family tree remodelled (2012)
    Nature Publishing Group (NPG)
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    Publication Date: 2012-10-13
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marin, Oscar -- England -- Nature. 2012 Oct 11;490(7419):185-6. doi: 10.1038/490185a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23060186" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*cytology/*embryology ; Humans ; Mice ; Models, Biological ; Neocortex/cytology/embryology ; Neurons/*cytology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 8
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    Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-09-12
    Description: The function of neural circuits depends on the generation of specific classes of neurons. Neural identity is typically established near the time when neurons exit the cell cycle to become postmitotic cells, and it is generally accepted that, once the identity of a neuron has been established, its fate is maintained throughout life. Here, we show that network activity dynamically modulates the properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81. In the adult cortex, Er81 protein levels define a spectrum of FS basket cells with different properties, whose relative proportions are, however, continuously adjusted in response to neuronal activity. Our findings therefore suggest that interneuron properties are malleable in the adult cortex, at least to a certain extent.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702376/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702376/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dehorter, Nathalie -- Ciceri, Gabriele -- Bartolini, Giorgia -- Lim, Lynette -- del Pino, Isabel -- Marin, Oscar -- 103714MA/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2015 Sep 11;349(6253):1216-20. doi: 10.1126/science.aab3415.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Centre for Developmental Neurobiology, Medical Research Council, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK. Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas and Universidad Miguel Hernandez, 03550 Sant Joan d'Alacant, Spain. ; Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas and Universidad Miguel Hernandez, 03550 Sant Joan d'Alacant, Spain. ; MRC Centre for Developmental Neurobiology, Medical Research Council, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, UK. Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas and Universidad Miguel Hernandez, 03550 Sant Joan d'Alacant, Spain. oscar.marin@kcl.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26359400" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/cytology/metabolism/*physiology ; DNA-Binding Proteins/genetics/*metabolism ; Interneurons/cytology/metabolism/*physiology ; Mice ; Mice, Mutant Strains ; Mitosis ; Mutation ; Nerve Net/cytology/metabolism/*physiology ; Transcription Factors/genetics/*metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases (2013)
    Springer Nature
    Details
    Publication Date: 2013-08-16
    Description: MBNL142 and MBNL143 gene isoforms, overexpressed in DM1-patient muscle, encode for nuclear proteins interacting with Src family kinases Cell Death and Disease 4, e770 (August 2013). doi:10.1038/cddis.2013.291 Authors: A Botta, A Malena, E Tibaldi, L Rocchi, E Loro, E Pena, L Cenci, E Ambrosi, M C Bellocchi, M A Pagano, G Novelli, G Rossi, H L Monaco, E Gianazza, B Pantic, V Romeo, O Marin, A M Brunati & L Vergani
    Keywords: MBNL1DM1SFKsmuscle
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Springer Nature
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  • 10
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    Characterization of the secondary flow in hexagonal ducts (2016)
    American Institute of Physics (AIP)
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    Publication Date: 2016-12-07
    Description: In this work we report the results of DNSs and LESs of the turbulent flow through hexagonal ducts at friction Reynolds numbers based on centerplane wall shear and duct half-height Re τ , c ≃ 180, 360, and 550. The evolution of the Fanning friction factor f with Re is in very good agreement with experimental measurements. A significant disagreement between the DNS and previous RANS simulations was found in the prediction of the in-plane velocity, and is explained through the inability of the RANS model to properly reproduce the secondary flow present in the hexagon. The kinetic energy of the secondary flow integrated over the cross-sectional area 〈 K 〉 yz decreases with Re in the hexagon, whereas it remains constant with Re in square ducts at comparable Reynolds numbers. Close connection between the values of Reynolds stress u w ¯ on the horizontal wall close to the corner and the interaction of bursting events between the horizontal and inclined walls is found. This interaction leads to the formation of the secondary flow, and is less frequent in the hexagon as Re increases due to the 120 ∘ aperture of its vertex, whereas in the square duct the 90 ∘ corner leads to the same level of interaction with increasing Re . Analysis of turbulence statistics at the centerplane and the azimuthal variance of the mean flow and the fluctuations shows a close connection between hexagonal ducts and pipe flows, since the hexagon exhibits near-axisymmetric conditions up to a distance of around 0.15 D H measured from its center. Spanwise distributions of wall-shear stress show that in square ducts the 90 ∘ corner sets the location of a high-speed streak at a distance z v + ≃ 50 from it, whereas in hexagons the 120 ∘ aperture leads to a shorter distance of z v + ≃ 38 . At these locations the root mean square of the wall-shear stresses exhibits an inflection point, which further shows the connections between the near-wall structures and the large-scale motions in the outer flow.
    Print ISSN: 1070-6631
    Electronic ISSN: 1089-7666
    Topics: Physics
    Published by American Institute of Physics (AIP)
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