ISSN:
0947-6539
Keywords:
clathrates
;
host-guest chemistry
;
hydrogen bonds
;
macrocyclic ligands
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis and characterisation of eleven new macrocyclic ethers (up to 96-membered [6+6] gigantocycle) with well-defined cavities are described. Syntheses of the macrocycles M1-M7 were performed under high-dilution conditions. A “supramolecular” purification method was used for the small [2+2] macrocycles M3-M7, which separated selectively from the reaction mixture on recrystallisation from a dichloromethane/diethyl ether solution mixture. This proved to be an excellent method for purifying [2+2] macrocyclic ethers containing 1,1-diphenylmethane moieties, and the separation was nearly quantitative. Molecular inclusion of dichloromethane in the cavities of noncovalently bonded macrocyclic ethers M2-M5 was studied by X-ray diffraction in the solid state. Additionally, clathrate formation was found for macrocycles M1 (including diethyl ether), M2 (including water), M6 (including benzene) and M7 (including benzene).
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19970030515
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