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  • 1
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    Employee relations 19 (1997), S. 67-80 
    ISSN: 0142-5455
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: The changes brought about by the new professional contract (1990) and the NHS reforms of 1991 are creating larger general practices which increasingly are seen as - and see themselves as - small businesses. As such the performance of practices will depend in part on their being able to manage employment relations effectively. Explores the nature of the employment relationship in general practice and reports the findings of a national survey of staff management procedures. While size is shown to have an important influence on structural arrangements, concludes that the future pattern of employment relations will crucially depend on the development of the management role in general practice and its articulation with established interests inside and outside the practices.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK and Boston, USA : Blackwell Publishing Ltd
    British journal of management 14 (2003), S. 0 
    ISSN: 1467-8551
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: In this paper, Pettigrew, Ferlie and McKee's concepts of receptive and non receptive contexts for change are examined using data from an evaluation study of a general medical practice implementing a Personal Medical Services Pilot between 1998 and 2001. Four questions concerning the applicability, associatedness, temporality and dynamism of the eight factors Pettigrew et al. identified as constitutive of receptivity are used in the analysis, which extends the original model through an operationalization yielding 21 ‘focal questions’. Although the process of change at the fieldwork site was stalled, the receptivity model is shown to have been a useful tool in identifying the factors blocking change. The analysis shows that when the eight factors are conceptualized in terms of the strength, direction and continuity of their influence, the receptivity metaphor provides a distinctive tool for the analysis of change. The paper concludes that further refinement of the model could provide a basis for the derivation of change management typologies.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    The @journal of management development 16 (1997), S. 284-301 
    ISSN: 0262-1711
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Examines the idea of learning in organizations with a particular focus on how organization members learn from experience, and how managers might foster a facilitating environment for learning. Contends that the idea of the "learning organization", as presented by Peter Senge in his book The Fifth Discipline, is problematic. Four dimensions of organization learning, absent or glossed over in Senge's work, are framed as questions and addressed from a psychoanalytic frame of inquiry. Concludes that the acknowledgement of repressed feelings about the human struggle to learn, and the process of containment which might enable an internal organization of experience to be reviewed and reconstituted, is necessary for organizational learning. This is understood as an "educated gut".
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 10 (1993), S. 588-592 
    ISSN: 1573-904X
    Keywords: theophylline ; sustained release ; bioavailability ; deconvolution ; in vivo/in vitro correlation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A novel multiparticulate sustained-release theophylline formulation, which consisted of spherical drug pellets coated with a rate-controlling membrane, was evaluated in vivo. Two preparations that differ solely in the coat thickness, and hence rate of in vitro drug release, were studied in comparison with a solution of the drug. Both preparations produced serum concentration profiles that are reflective of a slow and sustained rate of absorption. The in vivo release versus time profiles calculated using a deconvolution procedure showed that the two preparations differed in the rate but not the extent of drug release. Satisfactory correlation was also obtained between the in vivo and the in vitro results. When the two preparations were further compared using the parameters, time to reach peak concentration (T p), peak concentration (C p), and total area under the serum concentration versus time curves (AUC), a statistically significant difference was observed in the T p and C p values but not the AUC values, suggesting that the preparations differed in the rate but not the extent of absorption. In addition, the extent of absorption from both preparations was comparable to that obtained with the drug solution.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-904X
    Keywords: extrusion ; spheronization ; water movement ; magnetic resonance imaging (MRI) ; water mapping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To assess the potential of Magnetic Resonance Imaging (MRI) as a method of detecting water movement during the extrusion of pastes. Methods. Plug samples were made from mixtures of model materials and microcrystalline cellulose with two water contents at two different ram speeds to simulate ram extrusion. The extrusion process was stopped at different stages and analyzed for water distribution using MRI to assess the influence of water content and the speed of ram on water movement as the extrusion process progresses. Results. Two types of water movement were detected: vertical and radial. When extruding at the faster ram speed, water moved predominantly in the vertical direction, whereas when extruding at a slower ram speed it moved predominantly in the radial direction. At the beginning of the extrusion process a greater water movement in the wetter formulations was observed. Conclusions. MRI appears to be a useful approach to non-invasive water mapping, and is expected to contribute towards a greater understanding of the role of water in the extrusion of pastes.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1573-904X
    Keywords: gamma scintigraphy ; gastrointestinal transit ; mean caecum arrival time (MCAT) ; mean gastric residence time (MGRT) ; pellets ; statistical moments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The gastrointestinal transit of multiple units (e.g., pellets), as determined by gamma scintigraphy, has been characterized by the application of statistical moments. Stomach emptying profiles can be described comprehensively by Mean Gastric Residence Time (MGRT) and Variance of Gastric Residence Time (VGRT) and caecum arrival data by Mean Caecum Arrival Time (MCAT) and Variance of Caecal Arrival Time (VCAT). This maximizes the data available, which is not the case when only described as 50% values. The statistical moments provide different information about the data observed compared to the classical descriptors, as there was only limited correlation between these two sets of parameters. Statistical moments therefore provide an important quantification of the process studied, and they can be used in any statistical test, where it is required to compare different experimental conditions.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Natural hazards 16 (1997), S. 219-241 
    ISSN: 1573-0840
    Keywords: hazard mitigation ; federal emergency legislation ; mitigation policy ; mitigation programs ; emergency management ; IDNDR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract Exposure to natural hazards tends to be poorly understood and yet implicitly accepted by a large proportion of populations at risk. Some people through years of experience and time-tested coping mechanisms effectively respond to most hazards. Others, lacking skills and experience, are dependent on institutional response systems for immediate assistance and long-term recovery. Clearly, both approaches can reduce losses; however, the former strategies often prove more cost effective. How then, can loss reduction be handled with minimal external involvement? Are there not strategies that can reduce the impact of natural hazards and minimize exposure to these risks? Introduction of hazard mitigation strategies can begin to address these concerns in a timely and cost effective manner. Federal institutions in Canada and the United States recognize this potential, and in response, have developed policies and designed programs to limit the impact of hazards. To further collective thinking on hazard mitigation, this paper surveys current legislation and programs in both countries, makes a comparative assessment, and seeks to identify implications for mitigation policy within the framework of the Canadian IDNDR initiative. Perceptions of mitigation are explored to create a common foundation from which to address the nature, direction, and structure of mitigation policy and programs in Canada. Clarity of purpose, awareness of context, and acknowledgment of limitations and conflicts represent crucial aspects in the evolution of mitigation strategies. Through awareness, understanding, and a willingness to engage in dialogue new ways of thinking can be employed to decrease the impact of natural hazards on society and the environment.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Fast atom bombardment (FAB) is useful for the characterization of all major metabolites of the analgesic acetaminophen (APAP). It is particularly useful for providing mass spectra of the polar glucuronide and sulfate conjugates which eluded identification by field desorption and other more conventional methods of ionization. A protocol is described for the use of FAB in the identification of urinary APAP metabolites isolated by reversed phase high-performance liquid chromatography (HPLC) following therapeutic dosages of the drug. A tentative set of recommendations for the off-line use of HPLC and FAB is directed towards solving problems encountered when using these two analytical techniques in concert. In addition, a method for calculating the signal to background ratio (S/B) for analyte peaks in FAB spectra from selected relative ion intensities is proposed. Examples are presented that show the potential of S/B as an empirical parameter for judging the quality of FAB spectra.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 21 (1977), S. 1989-1997 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Permeabilities of noble gases, particularly argon, krypton, and xenon, were measured through a number of polymer films and coatings. Extrapolation of the log of the permeation coefficient versus the square of the gas molecular diameter was used to estimate radon permeability. An equation has been developed that can predict permeability to these noble gases as a function of the base polymer structure of the coating.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Journal of Morphology 171 (1982), S. 151-157 
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: An experiment was undertaken to measure directly the changing length of a jaw muscle during feeding in four intact, unanesthetized New Zealand White rabbits. Metal markers were implanted to define the anterior and posterior ends of the single belly of the digastric muscle and fluroscopic images were recorded on videotape while the animals fed on pelleted chow and carrot. Graphs of muscle length versus incisor separation were obtained by making measurements of single frames of the videotape record. The graphs revealed that when pelleted chow was being chewed the length of the diagastric muscle changed by no more than 9% of its greatest length; during the latter part of the closing stroke it changed very little. Incising and chewing carrot caused the digastric muscle to change in length continuously throughout the chewing cycle; incising carrot resulted in a 13% change in the length of the digastric muscle. The velocity of shortening is slightly less than one muscle length per second.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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