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  • 1
    Electronic Resource
    Electronic Resource
    Stimulation of mitotic recombination in Dictyostelium discoideum by ultraviolet irradiation (1982)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 14 (1982), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1982.tb08630.x
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  • 2
    Electronic Resource
    Electronic Resource
    Cell surface binding of adenosine to Dictyostelium and inhibition of pulsatile signalling (1982)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 13 (1982), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.1982.tb08298.x
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  • 3
    Electronic Resource
    Electronic Resource
    Pyridoxal kinase knockout of Dictyostelium complemented by the human homologue (2000)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 189 (2000), S. 0 
    Details
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The gene (pykA) encoding pyridoxal kinase which converts pyridoxal (vitamin B6) to pyridoxal phosphate was isolated from Dictyostelium discoideum using insertional mutagenesis. Cells of a pykA gene knockout grew poorly in axenic medium with low yield but growth was restored by the addition of pyridoxal phosphate. Sequencing indicated a gene, with one intron, encoding a predicted protein of 301 amino acids that was 42% identical in amino acid sequence to human pyridoxal kinase. After expression of the wild-type gene in Escherichia coli, the purified PykA protein product was shown to have pyridoxal kinase enzymatic activity with a Km of 8.7 μM for pyridoxal. Transformation of the Dictyostelium knockout mutant with the human pyridoxal kinase gene gave almost the same level of complementation as that seen using transformation with the wild-type Dictyostelium gene. Phylogenetic analysis indicated that the Dictyostelium amino acid sequence was closer to human pyridoxal kinase than to pyridoxal kinases of lower eukaryotes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-6968.2000.tb09229.x
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  • 4
    Electronic Resource
    Electronic Resource
    Genetics of Growth in Axenic Medium of the Cellular Slime Mould Dictyostelium discoideum (1974)
    [s.l.] : Nature Publishing Group
    Nature 247 (1974), S. 142-143 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] There are two independently derived strains capable of growth in axenic medium that are commonly used: Ax-2 (ref. 6) (ATCC-24397; derived from strain Ax-1 (ref. 3)) and Ax-3 (ref. 7) (also called A3). Mutants of strain Ax-3 which are temperature sensitive for growth were isolated using a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/247142a0
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  • 5
    Electronic Resource
    Electronic Resource
    Progress on slime mould morphogens (1978)
    [s.l.] : Nature Publishing Group
    Nature 271 (1978), S. 302-303 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALTHOUGH the cellular slime mould Dictyostelium discoideum has yielded a great deal of information about the intercellular signalling involved during the organism's aggregation phase (the phase when the starving amoebae swarm together to form a muticellular body) there has always been the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/271302a0
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  • 6
    Electronic Resource
    Electronic Resource
    Signal transduction and motility ofDictyostelium (1995)
    Springer
    Bioscience reports 15 (1995), S. 445-462 
    Details
    ISSN: 1573-4935
    Keywords: Myosin II ; cyclic GMP ; calcium ; motility ; myosin heavy chain kinase ; myosin light chain kinase ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This review is concerned with the roles of cyclic GMP and Ca2+ ions in signal transduction for chemotaxis ofDictyostelium. These molecules are involved in signalling between the cell surface cyclic AMP receptors and cytoskeletal myosin II involved in chemotactic cell movement. Evidence is presented for uptake and/or eflux of Ca2+ being regulated by cyclic GMP. The link between Ca2+, cyclic GMP and chemotactic cell movement has been explored using “streamer F” mutants whose primary defect is in the structural gene for the cyclic GMP-specific phosphodiesterase. This mutation causes the mutants to produce an abnormally prolonged peak of cyclic GMP accumulation in response to stimulation with the chemoattractant cyclic AMP. The production and relay of cyclic AMP signals is normal in these mutants, but certain events associated with movement are (like the cyclic GMP response) abnormally prolonged in the mutants. These events include Ca2+ uptake, myosin II association with the cytoskeleton and regulation of both myosin heavy and light chain phosphorylation. These changes can be correlated with changes in the shape of the amoebae after chemotactic stimulation. Other mutants in which the accumulation of cyclic GMP in response to cyclic AMP stimulation was absent produced no myosin II responses. A model is described in which cyclic GMP (directly or indirectly via Ca2+) regulates accumulation of myosin II on the cytoskeleton by regulating phosphorylation of the myosin heavy and light chain kinases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01204348
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  • 7
    Electronic Resource
    Electronic Resource
    The role of actin polymerization in Amoebal Chemotaxis (1986)
    New York, NY : Wiley-Blackwell
    BioEssays 5 (1986), S. 208-211 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A very rapid cellular event that follows chemotactic stimulation of leucocyte and cellular slime mould amoebae is a massive polymerization of G to F actin and its association with the cytoskeleton. In the cellular slime moulds this event occurs within 3-5 sec of cell surface binding of chemoattractants. It is correlated with rapid pseudopodium extension and may be a cell orientation mechanism. Curiously, before an amoebae moves away in the direction of its new pseudopodium it rounds up or “cringes” for 10-20 sec, an event correlated with a massive actin depolymerization. Transduction of the chemotactic signal involves Ca2+ release from internal stores by inositol trisphosphate.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950050505
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  • 8
    Electronic Resource
    Electronic Resource
    Streamer F mutants and chemotaxis of Dictyostelium (1992)
    New York, NY : Wiley-Blackwell
    BioEssays 14 (1992), S. 473-479 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Streamer F mutants have been found to be useful tools for studying the pathway of signal transduction leading to chemotactic cell movement. The primary defect in these mutants is in the structural gene for the cyclic GMP specific phosphodiesterase. This defect allows a larger and prolonged peak of cyclic GMP to be formed in response to the chemotactic stimulus, cyclic AMP. This characteristic aberrant pattern of cyclic GMP accumulation in the streamer F mutants has been correlated with similar patterns of changes in the influx of calcium from the medium, myosin II association with the cytoskeleton, myosin phosphorylation and a decrease in speed of movement of the amoebae. From these studies a sequence of events can be deduced that leads from cell surface cyclic AMP stimulation to cell polarization prior to movement of the amoebae in response to the chemotactic stimulus.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950140708
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  • 9
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    Cell interactions and development: Molecular mechanisms (1983)
    Cell Press
    Details
    Publication Date: 1983-12-01
    Print ISSN: 0968-0004
    Electronic ISSN: 1362-4326
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Cell Press
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  • 10
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    Eucaryotic microbes as model-developmental systems (1977)
    Cell Press
    Details
    Publication Date: 1977-11-01
    Print ISSN: 0968-0004
    Electronic ISSN: 1362-4326
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Cell Press
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