ISSN:
1435-232X
Keywords:
myotonic dystrophy
;
DNA diagnosis
;
apolipoprotein CII (APOC2)
;
D19S19
;
restriction fragment length polymorphisms (RFLPs)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Myotonic dystrophy (DM) is a genetic disease inherited by an autosomal dominant trait and characterized by multi-organ disorders. Although its biochemical basis has been unknown, the DM locus is closely linked to D19S19 and APOC2 on the long arm of chromosome 19 both in Japanese and Caucasian populations. Linkage studies of Japanese DM families using these polymorphic DNA markers detected two asymptomatic gene carriers in two unrelated families.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01900720
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