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  • 1
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    Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation (2015)
    Springer Nature
    Details
    Publication Date: 2015-05-01
    Description: Article Tumour progression is promoted by the generation of an immunosuppressive macroenvironment. Here, the authors demonstrate that the Inhibitor of Differentiation 1 promotes the switch from dendritic cell differentiation towards myeloid-derived suppressor cell expansion during tumour progression. Nature Communications doi: 10.1038/ncomms7840 Authors: Marianna Papaspyridonos, Irina Matei, Yujie Huang, Maria do Rosario Andre, Helene Brazier-Mitouart, Janelle C. Waite, April S. Chan, Julie Kalter, Ilyssa Ramos, Qi Wu, Caitlin Williams, Jedd D. Wolchok, Paul B. Chapman, Hector Peinado, Niroshana Anandasabapathy, Allyson J. Ocean, Rosandra N. Kaplan, Jeffrey P. Greenfield, Jacqueline Bromberg, Dimitris Skokos, David Lyden
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    Geology of Unaweep Canyon and its role in the drainage evolution of the northern Colorado Plateau (2015)
    Geological Society of America (GSA)
    In: Geosphere
    Details
    Publication Date: 2015-03-31
    Description: Unaweep Canyon (Colorado, USA) is a large, Precambrian-cored gorge that bisects the Uncompahgre Plateau of the northeastern Colorado Plateau, but has no through-flowing axial stream; it is drained by two underfit creeks (East and West Creek) that head at a divide within the canyon. The history of the canyon and its role in drainage evolution of the Colorado River system remain controversial. New mapping of both bedrock and Quaternary units as well as analyses of Quaternary deposits in and near the canyon shed light on its late Cenozoic history, and call into question whether the canyon was incised by a Cenozoic river, or merely exhumed by one. Gravels near the western mouth of Unaweep Canyon (Gateway, Colorado) exhibit a distinctive intermediate volcanic provenance recording the presence of an ancestral Gunnison River; the youngest gravels are dated to 1.46 ± 0.33 Ma. Previously documented coring within the canyon reveals a thick (locally 〉330 m) fill that includes a lacustrine succession (~140 m thick), dated to 1.4–1.3 Ma, overlain by stacked paleosols and a thick (~160 m) conglomeratic unit emplaced between 1.3 Ma and the present, in addition to a basal unit of possible late Paleozoic age. Lake formation reflects catastrophic mass wasting in western Unaweep Canyon that blocked the ancestral Gunnison River, causing partial backfilling of the canyon, and forcing the river to seek a lower elevation exit eastward by breaching the Mesozoic rim at the northeast end of Cactus Park (Mesa County, Colorado). Ultimately, the ancestral Gunnison River joined the lower elevation Colorado River near Grand Junction by 1.3 Ma, incising the East Creek of Unaweep Canyon during the overspilling event. Thermochronological data from Precambrian basement within Unaweep Canyon and Permian strata at the western mouth of the canyon indicate onset of incision in latest Miocene time (ca. 6–5 Ma), at a time-averaged rate of ~210–275 m/m.y. Onset of canyon occupation and rapid incision by the ancestral Gunnison River coincided with the timing of integration of the lower Colorado River system to the Gulf of California. The synchroneity of this incision across the Colorado Plateau supports the inference of an ultimate tectonic or epeirorogenic driver for this widespread incision and ultimate drainage integration. Several aspects of this data set support the previously published hypothesis that the ancestral Gunnison River exhumed a paleovalley. New mapping at the western mouth of the canyon documents a paleovalley filled with Permian strata that leads into the modern Precambrian-hosted gorge of Unaweep Canyon. In addition, the ancestral Gunnison River paralleled the Uncompahgre Plateau before making a 90° turn to bisect the structural axis in a manner that opposes both the northwestward plunge of the uplift and the northeastward dip of its northern flank. The rate of incision of Unaweep Canyon exceeds regional time-averaged incision rates, consistent with removal of sedimentary fill rather than incision of crystalline basement. This hypothesis implies that very ancient landforms can influence drainage evolution in even tectonically active landscapes.
    Electronic ISSN: 1553-040X
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 3
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    The DNA-encoded nucleosome organization of a eukaryotic genome (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-12-19
    Description: Nucleosome organization is critical for gene regulation. In living cells this organization is determined by multiple factors, including the action of chromatin remodellers, competition with site-specific DNA-binding proteins, and the DNA sequence preferences of the nucleosomes themselves. However, it has been difficult to estimate the relative importance of each of these mechanisms in vivo, because in vivo nucleosome maps reflect the combined action of all influencing factors. Here we determine the importance of nucleosome DNA sequence preferences experimentally by measuring the genome-wide occupancy of nucleosomes assembled on purified yeast genomic DNA. The resulting map, in which nucleosome occupancy is governed only by the intrinsic sequence preferences of nucleosomes, is similar to in vivo nucleosome maps generated in three different growth conditions. In vitro, nucleosome depletion is evident at many transcription factor binding sites and around gene start and end sites, indicating that nucleosome depletion at these sites in vivo is partly encoded in the genome. We confirm these results with a micrococcal nuclease-independent experiment that measures the relative affinity of nucleosomes for approximately 40,000 double-stranded 150-base-pair oligonucleotides. Using our in vitro data, we devise a computational model of nucleosome sequence preferences that is significantly correlated with in vivo nucleosome occupancy in Caenorhabditis elegans. Our results indicate that the intrinsic DNA sequence preferences of nucleosomes have a central role in determining the organization of nucleosomes in vivo.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658732/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658732/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaplan, Noam -- Moore, Irene K -- Fondufe-Mittendorf, Yvonne -- Gossett, Andrea J -- Tillo, Desiree -- Field, Yair -- LeProust, Emily M -- Hughes, Timothy R -- Lieb, Jason D -- Widom, Jonathan -- Segal, Eran -- R01 CA119176/CA/NCI NIH HHS/ -- R01 CA119176-03/CA/NCI NIH HHS/ -- R01 GM054692/GM/NIGMS NIH HHS/ -- R01 GM054692-11/GM/NIGMS NIH HHS/ -- R01 GM058617/GM/NIGMS NIH HHS/ -- R01 GM058617-11/GM/NIGMS NIH HHS/ -- R01 GM072518/GM/NIGMS NIH HHS/ -- R01 GM072518-01A1/GM/NIGMS NIH HHS/ -- R01 GM072518-02/GM/NIGMS NIH HHS/ -- R01 GM072518-03/GM/NIGMS NIH HHS/ -- R01 GM072518-04/GM/NIGMS NIH HHS/ -- England -- Nature. 2009 Mar 19;458(7236):362-6. doi: 10.1038/nature07667. Epub 2008 Dec 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19092803" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Caenorhabditis elegans/genetics ; Chickens ; Computational Biology ; Computer Simulation ; Eukaryotic Cells/*metabolism ; Genome, Fungal/*genetics ; Micrococcal Nuclease/metabolism ; Nucleosomes/*genetics/metabolism ; RNA, Messenger/genetics/metabolism ; Saccharomyces cerevisiae/*genetics/growth & development ; Sequence Analysis, DNA ; Transcription Factors/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    The giant lobes of Centaurus A observed at 118 MHz with the Murchison Widefield Array (2013)
    Mc; Kinley, B., Briggs, F., Gaensler, B. M., Feain, I. J., Bernardi, G., Wayth, R. B., Johnston-Hollitt, M., Offringa, A. R., Arcus, W., Barnes, D. G., Bowman, J. D., Bunton, J. D., Cappallo, R. J., Corey, B. E., Deshpande, A. A., de; Souza, L., Emrich, D., Goeke, R., Greenhill, L. J., Hazelton, B. J., Herne, D., Hewitt, J. N., Kaplan, D. L., Kasper, J. C., Kincaid, B. B., Koenig, R., Kratzenberg, E., Lonsdale, C. J., Lynch, M. J., McWhirter, S. R., Mitchell, D. A., Morales, M. F., Morgan, E., Oberoi, D., Ord, S. M., Pathikulangara, J., Prabu, T., Remillard, R. A., Rogers, A. E. E., Roshi, D. A., Salah, J. E., Sault, R. J., Shankar, N. U., Srivani, K. S., Stevens, J., Subrahmanyan, R., Tingay, S. J., Waterson, M., Webster, R. L., Whitney, A. R., Williams, A., Williams, C. L., Wyithe, J. S. B.
    Oxford University Press
    Details
    Publication Date: 2013-11-14
    Description: We present new wide-field observations of Centaurus A (Cen A) and the surrounding region at 118 MHz with the Murchison Widefield Array (MWA) 32-tile prototype, with which we investigate the spectral-index distribution of Cen A's giant radio lobes. We compare our images to 1.4 GHz maps of Cen A and compute spectral indices using temperature–temperature plots and spectral tomography. We find that the morphologies at 118 MHz and 1.4 GHz match very closely apart from an extra peak in the southern lobe at 118 MHz, which provides tentative evidence for the existence of a southern counterpart to the northern middle lobe of Cen A. Our spatially averaged spectral indices for both the northern and southern lobes are consistent with previous analyses, however we find significant spatial variation of the spectra across the extent of each lobe. Both the spectral-index distribution and the morphology at low radio frequencies support a scenario of multiple outbursts of activity from the central engine. Our results are consistent with inverse-Compton modelling of radio and gamma-ray data that support a value for the lobe age of between 10 and 80 Myr.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 5
    Electronic Resource
    Electronic Resource
    High field knight shift and hyperfine anisotropy for ^5^7Fe in bcc iron
    Amsterdam : Elsevier
    Journal of Magnetism and Magnetic Materials 15-18 (1980), S. 660-662 
    Details
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-8853(80)90709-X
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  • 6
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    High field knight shift and hyperfine anisotropy for 57Fe in bcc iron (1980)
    Elsevier
    Details
    Publication Date: 1980-01-01
    Print ISSN: 0304-8853
    Electronic ISSN: 1873-4766
    Topics: Physics
    Published by Elsevier
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  • 7
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    Predicting probabilities of streamflow intermittencyacross a temperate mesoscale catchment (2020)
    In:  Hydrology and Earth System Sciences
    Details
    Publication Date: 2020-12-10
    Description: The fields of eco-hydrological modelling and extreme flow prediction and management demand detailed information of streamflow intermittency and its corresponding landscape controls. Innovative sensing technology for monitoring of streamflow intermittency in perennial rivers and intermittent reaches improves data availability, but reliable maps of streamflow intermittency are still rare. We used a large dataset of streamflow intermittency observations and a set of spatial predictors to create logistic regression models to predict the probability of streamflow intermittency for a full year as well as wet and dry periods for the entire 247 km2 Attert catchment in Luxembourg. Similar climatic conditions across the catchment permit a direct comparison of the streamflow intermittency among different geological and pedological regions. We used 15 spatial predictors describing land cover, track (road) density, terrain metrics, soil and geological properties. Predictors were included as local-scale information, represented by the local value at the catchment outlet and as integral catchment information calculated as the mean catchment value over all pixels upslope of the catchment outlet. The terrain metrics catchment area and profile curvature were identified in all models as the most important predictors, and the model for the wet period was based solely on these two predictors. However, the model for the dry period additionally comprises soil hydraulic conductivity and bedrock permeability. The annual model with the most complex predictor set contains the predictors of the dry-period model plus the presence of tracks. Classifying the spatially distributed streamflow intermittency probabilities into ephemeral, intermittent and perennial reaches allows the estimation of stream network extent under various conditions. This approach, based on extensive monitoring and statistical modelling, is a first step to provide detailed spatial information for hydrological modelling as well as management practice.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 8
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    From one plot to many and from hillslopes to streams: Improving our understanding of catchment hydrology with a multi-scale experimental approach (2017)
    In:  Geophysical Research Abstracts Vol. 19, EGU2017-15424
    Details
    Publication Date: 2020-02-12
    Description: Sustainable water resources management needs to be based on sound process understanding. This is especially true in a changing world, where boundary conditions change and models calibrated to the status quo are no longer helpful. There is a general agreement in the hydrologic community that we are in need of a better process understanding and that one of the most promising ways to achieve this is by using nested experimental designs that cover a range of scales. In the here presented study we argue that while we might be able to investigate a certain process at a plot or hillslope in detail, the real power of advancing our understanding lies in site intercomparison and if possible knowledge transfer and generalization. The experimental design of the CAOS observatory is based on sensor clusters measuring ground-, soil and stream water, sap flow and climate variables in 45 hydrological functional units which were chosen from a matrix of site characteristics (geology, land use, hillslope aspect, and topographic positions). This design allows for site intercomparisons that are based on more than one member per class and thus does not only characterize between class differences but also attempts to identify within-class variability. These distributed plot scale investigations offer a large amount of information on plot scale processes and their variability in space and time (e.g. water storage dynamics and patterns, vertical flow processes and vadose zone transit times, transpiration dynamics and patterns). However, if we want to improve our understanding of runoff generation (and thus also of nutrient and contaminant transport and export to the stream) we need to also understand how these plots link up within hillslopes and how and when these hillslopes are connected to the stream. And certainly, this is again most helpful if we do not focus on single sites but attempt experimental designs that aim at intercomparison and generalization. At the same time, the investigation of hillslope-stream connectivity is extremely challenging due to the fact that there is a high 4-dimensional variability of the involved processes and most of them are hidden from view in the subsurface. To tackle this challenge we employed a number of different field methods ranging from hillslope scale irrigation and flow-through experiments, to in depth analyses of near stream piezometer responses and stream reach tracer experiments, and then moving on to the mesoscale catchment with network wide investigations of spatial patterns of stream temperature and electric conductivity as well as of the expansion and shrinkage of the network itself. In this presentation we will provide an overview of the rationale, approach, experimental design and ongoing work, the challenges we encountered and a synthesis of exemplary results.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 9
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    Time series of streamflow occurrence from 182 sites in ephemeral, intermittent and perennial streams in the Attert catchment, Luxembourg (2019)
    GFZ Data Services
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    Publication Date: 2020-02-12
    Language: English
    Type: info:eu-repo/semantics/workingPaper
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  • 10
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    Monitoring ephemeral, intermittent and perennial streamflow: a dataset from 182 sites in the Attert catchment, Luxembourg (2019)
    In:  Earth System Science Data
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    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/article
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