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  • 1
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    Transcriptional regulatory networks in Saccharomyces cerevisiae (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Tong Ihn -- Rinaldi, Nicola J -- Robert, Francois -- Odom, Duncan T -- Bar-Joseph, Ziv -- Gerber, Georg K -- Hannett, Nancy M -- Harbison, Christopher T -- Thompson, Craig M -- Simon, Itamar -- Zeitlinger, Julia -- Jennings, Ezra G -- Murray, Heather L -- Gordon, D Benjamin -- Ren, Bing -- Wyrick, John J -- Tagne, Jean-Bosco -- Volkert, Thomas L -- Fraenkel, Ernest -- Gifford, David K -- Young, Richard A -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):799-804.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399584" target="_blank"〉PubMed〈/a〉
    Keywords: Algorithms ; Cell Cycle ; Computational Biology ; DNA, Fungal/genetics/metabolism ; Feedback, Physiological ; Gene Expression Profiling ; *Gene Expression Regulation, Fungal ; *Genes, Fungal ; Genome, Fungal ; Models, Genetic ; *Promoter Regions, Genetic ; Protein Binding ; Saccharomyces cerevisiae/cytology/*genetics/growth & development/metabolism ; Saccharomyces cerevisiae Proteins/genetics/*metabolism ; Transcription Factors/genetics/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Control of pancreas and liver gene expression by HNF transcription factors (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-28
    Description: The transcriptional regulatory networks that specify and maintain human tissue diversity are largely uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined with promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets. We identified tissue-specific regulatory circuits formed by HNF1alpha, HNF4alpha, and HNF6 with other transcription factors, revealing how these factors function as master regulators of hepatocyte and islet transcription. Our results suggest how misregulation of HNF4alpha can contribute to type 2 diabetes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012624/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012624/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Odom, Duncan T -- Zizlsperger, Nora -- Gordon, D Benjamin -- Bell, George W -- Rinaldi, Nicola J -- Murray, Heather L -- Volkert, Tom L -- Schreiber, Jorg -- Rolfe, P Alexander -- Gifford, David K -- Fraenkel, Ernest -- Bell, Graeme I -- Young, Richard A -- N01-DK-9-2310/DK/NIDDK NIH HHS/ -- R01 HG002668/HG/NHGRI NIH HHS/ -- R01 HG002668-01/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1378-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988562" target="_blank"〉PubMed〈/a〉
    Keywords: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; Carbohydrate Metabolism ; *DNA-Binding Proteins ; Diabetes Mellitus, Type 2/etiology/genetics ; Gene Expression Profiling ; *Gene Expression Regulation ; Genome, Human ; Gluconeogenesis ; Hepatocyte Nuclear Factor 1 ; Hepatocyte Nuclear Factor 1-alpha ; Hepatocyte Nuclear Factor 1-beta ; Hepatocyte Nuclear Factor 4 ; Hepatocyte Nuclear Factor 6 ; Hepatocytes/*metabolism ; Homeodomain Proteins/*metabolism ; Humans ; Islets of Langerhans/*metabolism ; Lipid Metabolism ; *Nuclear Proteins ; Oligonucleotide Array Sequence Analysis ; Phosphoproteins/*metabolism ; Precipitin Tests ; Promoter Regions, Genetic ; RNA Polymerase II/metabolism ; Trans-Activators/*metabolism ; Transcription Factors/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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