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  • 1
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    Changes in rRNA transcription influence proliferation and cell fate within a stem cell lineage (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-01-18
    Description: Ribosome biogenesis drives cell growth and proliferation, but mechanisms that modulate this process within specific lineages remain poorly understood. Here, we identify a Drosophila RNA polymerase I (Pol I) regulatory complex composed of Under-developed (Udd), TAF1B, and a TAF1C-like factor. Disruption of udd or TAF1B results in reduced ovarian germline stem cell (GSC) proliferation. Female GSCs display high levels of ribosomal RNA (rRNA) transcription, and Udd becomes enriched in GSCs relative to their differentiating daughters. Increasing Pol I transcription delays differentiation, whereas reducing rRNA production induces both morphological changes that accompany multicellular cyst formation and specific decreased expression of the bone morphogenetic protein (BMP) pathway component Mad. These findings demonstrate that modulating rRNA synthesis fosters changes in the cell fate, growth, and proliferation of female Drosophila GSCs and their daughters.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084784/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084784/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Qiao -- Shalaby, Nevine A -- Buszczak, Michael -- R01 GM086647/GM/NIGMS NIH HHS/ -- R01GM045820/GM/NIGMS NIH HHS/ -- R01GM086647/GM/NIGMS NIH HHS/ -- T32 DK007745/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 17;343(6168):298-301. doi: 10.1126/science.1246384.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9148, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24436420" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Lineage/*genetics ; *Cell Proliferation ; Drosophila Proteins/genetics/metabolism ; Drosophila melanogaster/*cytology/genetics ; Female ; *Genes, rRNA ; Histone Acetyltransferases/genetics/metabolism ; Mutation ; Nuclear Proteins/genetics/metabolism ; Ovary/cytology/*physiology ; RNA Polymerase I/genetics/*metabolism ; Stem Cells/cytology/*physiology ; TATA-Binding Protein Associated Factors ; Transcription Factor TFIID/genetics/metabolism ; Transcription Factors/genetics/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary (2011)
    National Academy of Sciences
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    Publication Date: 2011-04-11
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 3
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    Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary [Developmental Biology] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-27
    Description: Specialized microenvironments called niches keep stem cells in an undifferentiated and self-renewing state. Dedicated stromal cells form niches by producing a variety of factors that act directly on stem cells. The size and signaling output of niches must be finely tuned to ensure proper tissue homeostasis. Although advances have been made in identifying factors that promote niche cell fate, the mechanisms that restrict niche cell formation during development and limit niche signaling output in adults remain poorly understood. Here, we show that the histone lysine-specific demethylase 1 (Lsd1) regulates the size of the germline stem cell (GSC) niche in Drosophila ovaries. GSC maintenance depends on bone morphogenetic protein (BMP) signals produced by a small cluster of cap cells located at the anterior tip of the germarium. Lsd1 null mutant ovaries carry small germline tumors containing an expanded number of GSC-like cells with round fusomes that display ectopic BMP signal responsiveness away from the normal niche. Clonal analysis and cell type-specific rescue experiments demonstrate that Lsd1 functions within the escort cells (ECs) that reside immediately adjacent to cap cells and prevents them from ectopically producing niche-specific signals. Temporally restricted gene knockdown experiments suggest that Lsd1 functions both during development, to specify EC fate, and in adulthood, to prevent ECs from forming ectopic niches independent of changes in cell fate. Further analysis shows that Lsd1 functions to repress decapentaplegic (dpp) expression in adult germaria. The role of Lsd1 in regulating niche-specific signals may have important implications for understanding how disruption of its mammalian homolog contributes to cancer and metastasis.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    Circularly Polarized Transparent Microstrip Patch Reflectarray Integrated with Solar Cell for Satellite Applications (2016)
    Hindawi
    Details
    Publication Date: 2016-01-01
    Description: Circularly polarized (CP) transparent microstrip reflectarray antenna is integrated with solar cell for small satellite applications at 10 GHz. The reflectarray unit cell consists of a perfect electric conductor (PEC) square patch printed on an optically transparent substrate with the PEC ground plane. A comparison between using transparent conducting polymers and using the PEC in unit-cell construction has been introduced. The waveguide simulator is used to calculate the required compensation phase of each unit cell in the reflectarray. The radiation characteristics of 13 × 13 CP transparent reflectarray antenna are investigated. A circularly polarized horn antenna is used to feed the reflectarray. The solar cell is incorporated with the transparent reflectarray on the same area. The solar-cell integration with the reflectarray reduces the maximum gain by about 0.5 dB due to the increase in the magnitude of the reflection coefficient. The results are calculated using the finite integral technique (FIT).
    Print ISSN: 1687-5826
    Electronic ISSN: 1687-5834
    Topics: Electrical Engineering, Measurement and Control Technology
    Published by Hindawi
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