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  • 1
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    Rare earth element composition of Mn deposits at Site H in the Pacific Ocean (2023)
    PANGAEA
    Details
    Publication Date: 2023-08-28
    Description: The table presents the REE contents and fluxes of manganese nodules and crusts from the Manganese Nodule Program (MANOP) site H (6.5° N, 93° W) in the eastern equatorial Pacific. Samples for this study were analysed for La, Ce, Nd, Sm, Eu, Tb, Yb and Lu by instrumental neutron activation. Analytical precision for the REE was within 10% for all samples, except for Nd and Tb which have peak interferences. Interferences due to U were negligible.
    Keywords: ALV1146; ALV-1146-C11; Alvin; BC; Box corer; Cerium; Core; CORE; Deposit type; DEPTH, sediment/rock; East Pacific Ocean; Elevation of event; Europium; Event label; Geochemistry; Identification; Indomed_leg_1; INMD01-26BX_B1 (MANOP Site H); INMD01-27BX_B5 (MANOP Site H); INMD01-34BX_B5 (MANOP Site H); INMD01-36BX_B3 (MANOP Site H); INMD-26BX_B1; INMD-27BX_B5; INMD-34BX_B5; INMD-36BX_B3; Lanthanum; Latitude of event; Longitude of event; Lutetium; manganese micronodule; manganese nodule; MANOP Site H, Pacific Ocean; Melville; Neodymium; Neutron activation analysis; NOAA and MMS Marine Minerals Geochemical Database; NOAA-MMS; ocean; Pacific Ocean; PLUTOIII; PLUTO III (MANOP Site H); Samarium; Sample type; sediment; Terbium; VLCN-1; VLCN-1-37BC; VLCN-1-52BX; VULCAN Leg 1; Ytterbium
    Type: Dataset
    Format: text/tab-separated-values, 352 data points
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  • 2
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    MANOP Site H manganese nodules and crusts chemical composition determined by atomic absorption spectrometry (AAS) (2023)
    PANGAEA
    Details
    Publication Date: 2023-11-23
    Description: Manganese nodules and crusts were sampled from box cores collected at the Manganese Nodule Program (MANOP) site H in the Eastern Equatorial Pacific ocean. For majority of site H nodule bottoms have smooth, lustrous patches, whereas nodule tops are generally rough and dull. The top/bottom orientation of each manganese nodule was labeled during curation. Most of the nodutes studied were cut in haIf, and a 3-5 mm layer was scraped from nodule tops and bottoms. The chemical analysis was performed on both top and bottom sides as well as on the whole specimen. Atomic absorption spectrometry (AAS) was used folIowing complete dissolution with HF and aqua regia in teflon bombs.
    Keywords: Aluminium; Atomic absorption spectrophotometry; Barium; BC; Box corer; Calcium; Cobalt; Copper; Deposit type; DEPTH, sediment/rock; Dredge, rock; DRG_R; East Pacific Ocean; Elevation of event; Event label; Geochemistry; Identification; Indomed_leg_1; INMD01-26BX_B1 (MANOP Site H); INMD01-27BX_B5 (MANOP Site H); INMD01-34BX_B5 (MANOP Site H); INMD01-36BX_B3 (MANOP Site H); INMD-26BX_B1; INMD-27BX_B5; INMD-34BX_B5; INMD-36BX_B3; Iron; Latitude of event; Longitude of event; Magnesium; Manganese; manganese micronodule; manganese nodule; MANOP Site H, Pacific Ocean; Melville; Nickel; NOAA and MMS Marine Minerals Geochemical Database; NOAA-MMS; ocean; Pacific Ocean; PLTO03MV; PLUTO-3; PLUTO-3-11D; PLUTO III (MANOP Site H); Potassium; Sample code/label; Sample type; sediment; Silicon; Sodium; Titanium; VLCN-1; VLCN-1-37BC; VLCN-1-40BX; VLCN-1-48BC; VLCN-1-50BC; VLCN-1-52BX; VLCN-1-55BX; VLCN-1-66BX; VLCN-1-68BX; VLCN-1-69BC; VULCAN Leg 1; Zinc
    Type: Dataset
    Format: text/tab-separated-values, 1326 data points
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  • 3
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    MANOP Site H manganese nodules and crusts chemical composition determined by instrumental neutron activation (INAA) (2023)
    PANGAEA
    Details
    Publication Date: 2023-11-23
    Description: Manganese nodules and crusts were sampled from box cores collected at the Manganese Nodule Program (MANOP) site H in the Eastern Equatorial Pacific ocean. For majority of site H nodule bottoms have smooth, lustrous patches, whereas nodule tops are generally rough and dull. The top/bottom orientation of each manganese nodule was labeled during curation. Most of the nodutes studied were cut in haIf, and a 3-5 mm layer was scraped from nodule tops and bottoms. The chemical analysis was performed on both top and bottom sides as well as on the whole specimen. They were analysed at the U.S. Geological Survey, Menlo Park using instrumental neutron activation analysis with high-resolution lithium-drifted germanium detectors. This method involves the meeasurement of gamma-ray emission after proper irradiation of the samples.
    Keywords: Antimony; Barium; BC; Box corer; Chromium; Cobalt; Deposit type; DEPTH, sediment/rock; Dredge, rock; DRG_R; East Pacific Ocean; Elevation of event; Event label; Geochemistry; Hafnium; Identification; Indomed_leg_1; INMD01-26BX_B1 (MANOP Site H); INMD01-27BX_B5 (MANOP Site H); INMD01-34BX_B5 (MANOP Site H); INMD01-36BX_B3 (MANOP Site H); INMD-26BX_B1; INMD-27BX_B5; INMD-34BX_B5; INMD-36BX_B3; Instrumental neutron activation analysis (INAA); Iron; Lanthanum; Latitude of event; Longitude of event; manganese micronodule; manganese nodule; MANOP Site H, Pacific Ocean; Melville; NOAA and MMS Marine Minerals Geochemical Database; NOAA-MMS; ocean; Pacific Ocean; PLTO03MV; PLUTO-3; PLUTO-3-11D; PLUTO III (MANOP Site H); Sample code/label; Sample type; Scandium; sediment; Thorium; Uranium; VLCN-1; VLCN-1-37BC; VLCN-1-52BX; VULCAN Leg 1
    Type: Dataset
    Format: text/tab-separated-values, 448 data points
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  • 4
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    MANOP Sites S and R manganese nodules chemical composition determined by atomic absorption spectrometry (AAS) (2023)
    PANGAEA
    Details
    Publication Date: 2023-11-23
    Description: Manganese nodules were sampled from box cores collected at the Manganese Nodule Program (MANOP) site S (Clarion-Clipperton Fracture Zone) and site R (Murray Fracture Zone) in the Central Pacific ocean. For these sites nodule tops are smoother than nodule bottoms, which commonly have a gritty texture. The top/bottom orientation of each manganese nodule was labeled during curation. Most of the nodutes studied were cut in haIf, and a 3-5 mm layer was scraped from nodule tops and bottoms. The chemical analysis was performed on both top and bottom sides as well as on the whole specimen. They were analysed at the U.S. Geological Survey, Menlo Park using instrumental neutron activation analysis with high-resolution lithium-drifted germanium detectors. This method involves the meeasurement of gamma-ray emission after proper irradiation of the samples.
    Keywords: Aluminium; Atomic absorption spectrometry (AAS); Barium; BC; Box corer; Calcium; Cobalt; Copper; Deposit type; DEPTH, sediment/rock; Elevation of event; Event label; Geochemistry; Identification; Iron; K7905; K7905-054BC; K7905-062BC; K7905-101BC; K7905-104BC; Knorr; Latitude of event; Longitude of event; Magnesium; Manganese; manganese micronodule; manganese nodule; MANOP; MANOP Site S, Pacific Ocean; Melville; MN76-01, Pleiades; Nickel; NOAA and MMS Marine Minerals Geochemical Database; NOAA-MMS; ocean; Pacific Ocean; PLDS04MV-109BX; PLDS-4; Potassium; RAMA; RAMA (MANOP Site R); RAMA01WT; RAMA01WT-15BX; RAMA01WT-20BX; Sample code/label; Sample type; sediment; Silicon; Sodium; Thomas Washington; Titanium; Zinc
    Type: Dataset
    Format: text/tab-separated-values, 474 data points
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  • 5
    Electronic Resource
    Electronic Resource
    Rare earth element fluxes and geochemical budget in the eastern equatorial Pacific (1984)
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 444-447 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Studies of the fractionation of individual REE from one another have provided insight into the geochemical behaviour of REE in the marine environment1"3. Ce, because of its unique preference for the 4+ state in seawater, may be more readily adsorbed onto water column particles4 and incorporated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/307444a0
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    Paper (German National Licenses)
    Fulltext
  • 6
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    Comparison of RefSeq protein-coding regions in human and vertebrate genomes (2013)
    BioMed Central
    Details
    Publication Date: 2013-09-26
    Description: Background: Advances in high-throughput sequencing technology have yielded a large number of publicly available vertebrate genomes, many of which are selected for inclusion in NCBI's RefSeq project and subsequently processed by NCBI's eukaryotic annotation pipeline. Genome annotation results are affected by differences in available support evidence and may be impacted by annotation pipeline software changes over time. The RefSeq project has not previously assessed annotation trends across organisms or over time. To address this deficiency, we have developed a comparative protocol which integrates analysis of annotated protein-coding regions across a data set of vertebrate orthologs in genomic sequence coordinates, protein sequences, and protein features. Results: We assessed an ortholog dataset that includes 34 annotated vertebrate RefSeq genomes including human. We confirm that RefSeq protein-coding gene annotations in mammals exhibit considerable similarity. Over 50% of the orthologous protein-coding genes in 20 organisms are supported at the level of splicing conservation with at least three selected reference genomes. Approximately 7,500 ortholog sets include at least half of the analyzed organisms, show highly similar sequence and conserved splicing, and may serve as a minimal set of mammalian "core proteins" for initial assessment of new mammalian genomes. Additionally, 80% of the proteins analyzed pass a suite of tests to detect proteins that lack splicing conservation and have unusual sequence or domain annotation. We use these tests to define an annotation quality metric that is based directly on the annotated proteins thus operates independently of other quality metrics such as availability of transcripts or assembly quality measures. Results are available on the RefSeq FTP site [1]. Conclusions: Our multi-factored analysis demonstrates a high level of consistency in RefSeq protein representation among vertebrates. We find that the majority of the RefSeq vertebrate proteins for which we have calculated orthology are good as measured by these metrics. The process flow described provides specific information on the scope and degree of conservation for the analyzed protein sequences and annotations and will be used to enrich the quality of RefSeq records by identifying targets for further improvement in the computational annotation pipeline, and by flagging specific genes for manual curation.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
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  • 7
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    Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A (2008)
    American Society of Hematology
    Details
    Publication Date: 2008-09-01
    Description: Previous studies showed that Fanconi anemia (FA) murine stem cells have defective reconstitution after bone marrow (BM) transplantation. The mechanism underlying this defect is not known. Here, we report defective homing of FA patient BM progenitors transplanted into mouse models. Using cells from patients carrying mutations in FA complementation group A (FA-A), we show that when transplanted into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) recipient mice, FA-A BM cells exhibited impaired homing activity. FA-A cells also showed defects in both cell-cell and cell-matrix adhesion. Complementation of FA-A deficiency by reexpression of FANCA readily restored adhesion of FA-A cells. A significant decrease in the activity of the Rho GTPase Cdc42 was found associated with these defective functions in patient-derived cells, and expression of a constitutively active Cdc42 mutant was able to rescue the adhesion defect of FA-A cells. These results provide the first evidence that FA proteins influence human BM progenitor homing and adhesion via the small GTPase Cdc42-regulated signaling pathway.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 8
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    A Cell-Autonomous Defect of Bone Marrow Hematopoietic Stem/Progenitor Cells and Impaired Stromal Function in FA-a Patients (2008)
    American Society of Hematology
    Details
    Publication Date: 2008-11-16
    Description: Fanconi anemia (FA) is a devastating blood disease associated with bone marrow (BM) failure. Currently the effective treatment for FA is BM transplantation. We and others showed that FA murine hematopoietic stem and progenitor cells (HSC/Ps) have defective hematopoietic reconstitution after BM transplantation. In addition, several clinical gene therapy trials in FA patients have failed to show sustained engraftment of FA HSC/Ps complemented with a functional FA gene. The mechanism underlying this engraftment defect remains unknown. To determine whether the poor engraftment of FA HSC/Ps observed in mouse knockout models and clinical gene therapy trials in FA patients results from an intrinsic defect of the FA HSC/Ps or an impaired microenvironment in the FA bone marrow, we have assessed the self-renewal ability of HSC/Ps and hematopoietic supportive capacity of BM stromal cells from FA-A patients. First, we performed quantitative cobblestone area-forming cell (CAFC) assays using MS-5 stromal layer. CAFCs were enumerated at 2 and 5 weeks of cocultures between BM mononuclear cells from a normal donor and three FA-A patients. Early-appearing CAFCs (week 2) represent transient repopulating cells equivalent to progenitor colony-forming units (CFUs), whereas late-appearing CAFCs (week 5) are representative of long-term repopulating stem cells. The frequency of FA-A CAFCs was 15–20 folds decreased compared with that of the normal donor at both week 2 and week 5. Second, we carried out long-term culture-initiating cell (LTC-IC) assays using BM mononuclear cells and BM-derived stromals from normal donors or FA-A patients. Compared to coculture with normal stromal cells, the recovery of colony forming cells (CFCs) that grew on FA-A stromal layer after 5–6 weeks incubation was significantly decreased for either normal or FA-A HSC/Ps (41.4% ± 3.1 CFC in normal HSC/Ps - normal stroma compared to 14.3% ± 1.6 CFC in normal HSC/Ps – FA-A stroma and 2.4 ± 0.6 CFC in FA-A HSC/Ps- FA-A stroma). Finally, we conducted CFC and cell-cell adhesion assays using BM-derived stromal cells from normal donors and FA-A patients. We observed that FA-A BM stroma failed to support HSC/P cells from either normal donors or FA-A patients. Specifically, severe adhesion defect was found in adhesion of normal and FA-A HSC/Ps with FA-A stromal layer (5.5% ± 0.6 CFC adhesion in normal HSC/Ps - normal stroma compared to 2.4% ± 0.5 CFC adhesion in normal HSC/Ps – FA-A stroma and 1.0 ± 0.7 CFC adhesion in FA-A HSC/Ps- FA-A stroma). These results suggest that both a cell-autonomous defect of FA HSC/Ps and an impaired FA BM microenvironment may contribute to the abnormal hematopoiesis in FA.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Published by American Society of Hematology
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  • 9
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    Ferromanganese nodules from MANOP Sites H, S, and R—Control of mineralogical and chemical composition by multiple accretionary processes (1984)
    Elsevier
    Details
    Publication Date: 1984-05-01
    Print ISSN: 0016-7037
    Electronic ISSN: 1872-9533
    Topics: Chemistry and Pharmacology , Geosciences
    Published by Elsevier
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  • 10
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    High-resolution studies of the summit of Axial Volcano (1990)
    American Geophysical Union
    Details
    Publication Date: 1990-01-01
    Print ISSN: 0148-0227
    Electronic ISSN: 2156-2202
    Topics: Geosciences
    Published by American Geophysical Union
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