ISSN:
1476-4687
Source:
Nature Archives 1869 - 2009
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Notes:
[Auszug] The enzymatic activity of COX involves bis-oxygenation of arachidonic acid to PGG2, which is further reduced to PGH2 in a peroxidase reaction by the same protein11. NSAIDs act at the cyclooxygenase active site, and most inhibit both COX-1 and COX-2 with little specificity12-13, leading to serious ...
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1038/384644a0
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