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  • 1
    Electronic Resource
    Electronic Resource
    Molecular heterogeneity underlying the G6PD Mediterranean phenotype (1992)
    Springer
    Human genetics 〈Berlin〉 88 (1992), S. 688-690 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary As part of a study aiming to define the molecular basis of glucose-6-phosphate dehydrogenase (G6PD) deficiency, we analysed a sample from a Portugese boy with a family history of favism. Although the biochemical properties of red-cell G6PD from this subject were similar to those of the common variant G6PD Mediterranean, the corresponding mutation (563 C→T) was not present. Instead, polymerase chain reaction (PCR) amplification and sequencing of the entire gene detected a C→T transition at nucleotide 592 in exon VI, changing an arginine residue to a cysteine residue only 10 amino acids downstream from the Mediterranean mutation. Single-strand conformation polymorphism analysis of a PCR-amplified DNA fragment spanning exons VI and VII of the G6PD gene has detected the same mutation, confirmed by sequencing, in a G6PD-deficient patient from Southern Italy. We name this new variant G6PD Coimbra.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265298
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  • 2
    Electronic Resource
    Electronic Resource
    Environmental effects from burning oil wells in Kuwait (1991)
    [s.l.] : Nature Publishing Group
    Nature 351 (1991), S. 363-367 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Model calculations, constrained by satellite observations, indicate that most of the smoke from the oil fires in Kuwait will remain in the lowest few kilometres of the troposphere. Beneath the plume there is a severe reduction in daylight, and a day-time temperature drop of ~10 °C within ~200 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/351363a0
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  • 3
    Electronic Resource
    Electronic Resource
    On the influence of variations in Monin-Obukhov length on horizontal roll vortices in an inversion-capped planetary boundary layer (1983)
    Springer
    Boundary layer meteorology 27 (1983), S. 43-68 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Observations of the planetary boundary layer under conditions with strong or moderate winds often show the large-scale boundary-layer motions to be highly elongated in a direction close to that of the geostrophic wind. The properties of such large-scale motions are examined by means of a two-dimensional numerical model. The small-scale turbulence is parameterized using a buoyancy-dependent mixing-length hypothesis. The objective is to understand how the properties and dynamics of such rolls depend upon the relative importance of shear and buoyancy forces.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119971
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  • 4
    Electronic Resource
    Electronic Resource
    A numerical study of cloud streets in the planetary boundary layer (1985)
    Springer
    Boundary layer meteorology 32 (1985), S. 281-304 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract A two-dimensional numerical model is used to study the influence of small non-precipitating clouds on horizontal roll vortices in the planetary boundary layer. The model explicitly represents the large-scale two-dimensional motions whilst small-scale eddies are parameterized by a buoyancy dependent mixing-length hypothesis. It is applied to conditions corresponding to an observed case of cloud street formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121884
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  • 5
    Electronic Resource
    Electronic Resource
    The sensitivity of large-eddy simulation of turbulent shear flow to subgrid models (1994)
    Springer
    Boundary layer meteorology 70 (1994), S. 133-150 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Previous large-eddy simulations of turbulent shear flows have shown significant sensitivity to some aspects of the subgrid-scale turbulence models. In particular, Mason and Thomson (1992) demonstrated a marked improvement in simulations through the inclusion of stochastic stress variations in the subgrid model. Here a series of simulations is presented with a view to exploring the general sensitivity to such a subgrid model and in particular to the size and nature of the stochastic stress variations. The model proposed by Mason and Thomson is found to be fairly satisfactory but some quantitative uncertainty remains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00712526
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  • 6
    Electronic Resource
    Electronic Resource
    Boundary-layer flow over low hills (1987)
    Springer
    Boundary layer meteorology 39 (1987), S. 107-132 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract In 1975 Jackson and Hunt observed that there had, until that time, been few attempts to relate measurements of wind velocity on hills to the local topography. The succeeding ten years have seen substantial research effort aimed at rectifying this omission. The field measurements, in conjunction with theoretical, numerical and wind tunnel studies now provide a good basis for a preliminary description of neutrally stratified boundary-layer flow over low hills. There are still gaps in the description and understanding of the flow but many more data are now available. The present review attempts to summarize recent field experiments that have been conducted on boundary-layer flow over low hills and to review what we have learnt from them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00121870
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  • 7
    Electronic Resource
    Electronic Resource
    Flow over the summit of an isolated hill (1986)
    Springer
    Boundary layer meteorology 37 (1986), S. 385-405 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Observations of the mean flow and turbulence statistics over the summit of an isolated, roughly circular hill, Nyland hill, are presented, Nyland hill rises 70 m above the surrounding terrain and has a base diameter of about 500 m. The summit of the hill is very smooth and allows representative measurements to be made close to the surface. The flow speed 8 m above the summit is increased by a factor of 2 over the upstream speed 8 m above level terrain, and flow separation occurs in the lee of the hill. The mean velocity profile over the summit shows an increase in velocity with height up to about 2 m and then a near constant velocity between 2 and 16 m. The flow perturbation relative to the upstream profile is thus a maximum at about 2 m. The measurements of turbulence structure show how the influence of the hill depends on the length scale of the turbulent eddies involved. Scales greater than the scale of the hill are modified through the flow speed-up whilst scales shorter than the hill suffer complex changes. The short-scale turbulence over the summit is only in local equilibrium in the lowest fraction of a metre. Above this equilibrium region, there is a complex adjustment towards the rapid distortion dynamics which appear to dominate at heights above about 8 m. The detailed results are compared with previous studies and available theories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00117485
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  • 8
    Electronic Resource
    Electronic Resource
    On the influence of topography on plume dispersal (1981)
    Springer
    Boundary layer meteorology 21 (1981), S. 137-157 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Numerical integrations of the three-dimensional Navier-Stokes equations for the problem of plume dispersal in laminar flow over topography are presented. The results show the consequences of various mean flow advection effects in the presence of a constant viscosity. The two effects of particular interest are the large changes in surface concentration which can arise through plume impact, and the increased plume dispersion caused by the flow distortion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02033933
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  • 9
    Electronic Resource
    Electronic Resource
    Large-Eddy Simulation of the stably-stratified atmospheric boundary layer (1990)
    Springer
    Boundary layer meteorology 53 (1990), S. 117-162 
    Details
    ISSN: 1573-1472
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Large-Eddy Simulation of stable boundary layers (SBLs) has been considered particularly difficult, indeed perhaps impossible with present computational resources. Here we present a new series of successful simulations of SBLs over uniform, flat terrain, using an approach previously successful for neutral and convective conditions, and showing that essentially the same model can handle all three main dry types of atmospheric boundary layer. We consider both technical requirements for successful and accurate SBL simulations and the observed characteristics of the simulated SBL. We discuss the evolution (in some cases to quasi-steady states) and compare with theory and experimental data. Effects of static-stability on the flow are analyzed using one-point and two-point statistics. Results show the development of a shear-driven SBL, with little sign of distinctively wavelike motions. The flow statistics are found to be consistent with local scaling, and that framework is used to compare with other data and theoretical models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00122467
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  • 10
    Electronic Resource
    Electronic Resource
    The expression of heat shock genes during normal development in Drosophila melanogaster (heat shock/abundant transcripts/developmental regulation) (1984)
    Springer
    Molecular genetics and genomics 194 (1984), S. 73-78 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Drosophila melanogaster cells and tissues respond to heat shock by dramatically altering their pattern of transcription and translation, leading to the rapid synthesis of a small number of polypeptides, the heat shock proteins (hsps). By using cloned hsp DNA we have detected sequences complementary to heat shock genes in RNA prepared from non-heat-shocked animals of different developmental stages. Hsp 83 mRNA is present at high levels in all stages examined. Hsp 68 and 70 mRNAs are present at very low levels in most stages and at slightly higher concentration in pupae. Hsp 26 and 27 mRNAs are detected in embryos. Hsp 23, 26 and 27 mRNA are barely detectable in early third instar larvae but are major components of late third instar and early pupal RNA. Hsp 22 mRNA is also detected in early pupae. Later in development the levels of the small hsp mRNAs decrease but a further peak in abundance of hsp 26 and 27 mRNAs is found in mature adult females.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00383500
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