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  • 1
    Electronic Resource
    Electronic Resource
    RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia (2004)
    [s.l.] : Nature Publishing Group
    Nature medicine 10 (2004), S. 816-820 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The dominant polyglutamine expansion diseases, which include spinocerebellar ataxia type 1 (SCA1) and Huntington disease, are progressive, untreatable, neurodegenerative disorders. In inducible mouse models of SCA1 and Huntington disease, repression of mutant allele expression improves disease ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1076
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Identification of PDGFR as a receptor for AAV-5 transduction (2003)
    [s.l.] : Nature Publishing Group
    Nature medicine 9 (2003), S. 1306-1312 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Understanding the process of vector transduction has important implications for the application and optimal use of a vector system for human gene therapy. Recent studies with vectors based on adeno-associated virus type 5 (AAV-5) have shown utility of this vector system in the lung, central nervous ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm929
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    Paper (German National Licenses)
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  • 3
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    Results of an ex-situ experiment testing the effects of mining-generated sediment plumes on the cold-water octocoral Dentomuricea aff. meteor in the Azores (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Corals were collected from the summit of Condor Seamount (Azores, NE Atlantic) at depths between 185-210 m in August 2014. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. PMS particles were obtained by grinding PMS inactive chimney rocks collected at the hydrothermal vent field Lucky Strike. Both particle types were delivered at a concentration of 25 mg L-1. The putative effects of PMS particles were evaluated through measurements of the coral physiological responses at the levels of the organism (oxygen consumption, ammonium excretion), tissue (bioaccumulation of metals) and cell (enzyme activity and gene expression).
    Keywords: ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Condor Seamounts; enzyme activity; experiment; gene expression; iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Sampling_Azores_Cold_Water_Octocoral
    Type: Dataset
    Format: application/zip, 7 datasets
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    DATA PANGAEA
  • 4
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    Cold-water octocoral Viminella flagellum respiration rates during an acute Cu exposure (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: Herein we report the respiration rates (O2 consumption) of the cold-water coral Viminella flagellum exposed to acute Cu concentrations. In a lab experiment, sixty nubbins of V. flagellum were distributed in six aquaria of 8 L (ten nubbins per aquarium) of each Cu solution (0 (control); 60; 150; 250; 450 and 600 μg/L) for 96 h. After this period, four nubbins from each Cu treatment, selected randomly, were incubated individually for 6 h in glass chambers filled with ca. 110 mL of 0.2 μm pre-filtered seawater, with the respective Cu dilutions (4 chambers per Cu concentration). The incubation period was set to 6 h to record changes in O2 consumption without exposing corals to oxygen levels below 80 % (air saturation, a.s.). During the incubation period, dissolved O2 (μmol/L) depletion rates were recorded every 30 min and corrected by the corresponding rates/variations in chambers without corals. Coral respiration rates were normalized to the coral surface area and time. Results are presented by µmol of O2 consumption per m2 per h.
    Keywords: Azores_Deep_Octocoral_Sampling_Viminella_flagellum; Chamber number; cold-water octocoral; Condor Seamounts; copper; Copper; iAtlantic; INCUB; Incubation; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; Marine Ecosystem Restoration in Changing European Seas; MERCES; Oxygen consumption; Respiration rate; Specimen identification
    Type: Dataset
    Format: text/tab-separated-values, 114 data points
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  • 5
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    Suspended sediment concentrations of an ex-situ experiment with the cold-water octocoral Dentomuricea aff. meteor in the Azores (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. The concentration of suspended PMS and quartz particles in each treatment was measured during an exposure period of 4 hours. Suspended particle concentrations were measured one minute after particle addition, and then at intervals of 5, 15, 30 minutes, 1 hour, 2 hours and 4 hours after particle addition in the PMS and quartz particle treatments and in control aquaria with no particle addition.
    Keywords: Aquarium number; ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Condor Seamounts; enzyme activity; experiment; gene expression; iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; Measurement duration; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Sampling_Azores_Cold_Water_Octocoral; Suspended polymetallic sulfide; Suspended quartz
    Type: Dataset
    Format: text/tab-separated-values, 92 data points
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    DATA PANGAEA
  • 6
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    Aquarium monitoring of an ex-situ experiment involving the cold-water octocoral Dentomuricea aff. meteor (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. Seawater physical-chemical parameters were measured daily in each aquarium. Seawater salinity was measured with a S30 SevenEasy™ conductivity meter, pH and temperature with a glass electrode (Crison pH 25+), and oxygen with a Fibox4 (PreSens) with a Oxygen Dipping Probe DP-PSt3. Seawater samples for inorganic nutrient analyses were collected on times 0 (immediately before the start of the experiment), and once a week on days 6, 13, 20 and 27 of the experiment and determined using a colorimetric autoanalyzer Sanplus with segmented flow.
    Keywords: Ammonia+Ammonium; Aquarium number; ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Colorimetric autoanalysis; Condor Seamounts; Conductivity meter, S30 SevenEasy; Dissolved oxygen, in water, interpolated; enzyme activity; experiment; Experimental treatment; Experiment duration; Fiber optic oxygen meter, Fibox 4, Presens, Germany; gene expression; Glass electrode (Crison pH 25+); iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; metabolism; metal bioaccumulation; MIDAS; Nitrate; North Atlantic; octocorals; pH; Salinity; Sampling_Azores_Cold_Water_Octocoral; Temperature, water
    Type: Dataset
    Format: text/tab-separated-values, 913 data points
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  • 7
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    Metal bioaccumulation by the cold-water octocoral Dentomuricea aff. meteor during an ex-situ experiment testing the effects of mining-generated sediment plumes (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. Trace elements in the tissues and skeletons of corals at the end of the experiment were quantified by a quadrupole ICPMS (Thermo Elemental, X-Series). The metal concentrations in coral tissues are given in microgram per gram of dry weight tissue (μg g-1; dw).
    Keywords: Aquarium number; ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Cobalt; Condor Seamounts; Copper; enzyme activity; experiment; Experimental treatment; gene expression; iAtlantic; ICP-MS; Inductively coupled plasma mass spectrometry; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; Manganese; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Sample material; Sampling_Azores_Cold_Water_Octocoral; Specimen identification
    Type: Dataset
    Format: text/tab-separated-values, 182 data points
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  • 8
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    Metabolic rates of the cold-water octocoral Dentomuricea aff. meteor during an ex-situ experiment in the Azores (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. Integrated measurements of coral respiration and ammonium release rates were carried out by closed-chamber incubation in cylindrical acrylic chambers on days 0, 13 and 27 of the experiment using an oxygen meter Fibox4 with a PSt3 sensor (PreSens, Germany). Coral respiration and excretion rates were normalized to the coral skeletal surface area.
    Keywords: Ammonium, excretion; Aquarium number; ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Colorimetric autoanalysis; Condor Seamounts; enzyme activity; experiment; Experimental treatment; Experiment duration; Fiber optic oxygen meter, Fibox 4, Presens, Germany; gene expression; iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; Managing Impacts of Deep-seA reSource exploitation; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Respiration rate, oxygen; Sampling_Azores_Cold_Water_Octocoral; Specimen identification
    Type: Dataset
    Format: text/tab-separated-values, 233 data points
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  • 9
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    Stress biomarkers in the cold-water octocoral Dentomuricea aff. meteor during an ex-situ experiment in the Azores (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. Antioxidant stress related biomarkers (glutathione S−transferase, superoxide dismutase, catalase, malondialdehyde) in D. aff. meteor tissues were used to evaluate the degree of cellular stress induced by exposure to PMS and quartz particles at times 0 and 13 days in all treatments and from the control and quartz treatments also at time 27 days of the experiment.
    Keywords: Activity description; Aquarium number; ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Biomarker; Cnidaria; Condor Seamounts; enzyme activity; experiment; Experimental treatment; Experiment duration; gene expression; iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Sampling_Azores_Cold_Water_Octocoral; SPEC; Specimen identification; Spectrophotometer
    Type: Dataset
    Format: text/tab-separated-values, 702 data points
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  • 10
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    Gene expression by the cold-water octocoral Dentomuricea aff. meteor during an ex-situ experiment testing the effects of mining-generated sediment plumes (2022)
    PANGAEA
    Details
    Publication Date: 2024-02-27
    Description: We report the results of an aquaria-based experiment testing the effects of suspended particles generated during potential mining activities, on a common habitat-building coral species in the Azores, Dentomuricea aff. meteor. Coral fragments were maintained in 10-L aquaria and exposed to three experimental treatments for a period of four weeks at the DeepSeaLab aquaria facilities (Okeanos-University of the Azores): (1) control conditions (no added sediments); (2) suspended polymetallic sulphide (PMS) particles; (3) suspended quartz particles. Gene expression profiles in D. aff. meteor were used to evaluate the physiological pathways involved in the response to exposure to PMS and quartz particles. Coral fragments were collected from each treatment at times 0, 3, and 13 days and for the control and quartz treatments also at time 27 days. The study targeted genes involved in cellular stress and antioxidant reaction system (heat shock protein, superoxide dismutase, ferritin), cell structure/integrity (α-carbonic anhydrase, receptor-type protein tyrosine phosphatase) and immune responses (toll-like receptor, lysozyme, rel homology domain, ferritin).
    Keywords: ATLAS; A Trans-Atlantic assessment and deep-water ecosystem-based spatial management plan for Europe; Cnidaria; Condor Seamounts; Cycles; enzyme activity; experiment; Experimental treatment; Experiment duration; gene expression; Gene expression, fold change, relative; Gene expression, fold change, relative, standard error; Gene name; iAtlantic; Integrated Assessment of Atlantic Marine Ecosystems in Space and Time; JPI Oceans - Ecological Aspects of Deep-Sea Mining; JPIO-MiningImpact; Managing Impacts of Deep-seA reSource exploitation; metabolism; metal bioaccumulation; MIDAS; North Atlantic; octocorals; Real-Time PCR, CFX Connect™ Real-Time PCR Detection System (BioRad); Sampling_Azores_Cold_Water_Octocoral; Specimen identification
    Type: Dataset
    Format: text/tab-separated-values, 2488 data points
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