Publication Date:
2018-09-06
Description:
RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation, Published online: 05 September 2018; doi:10.1038/s41467-018-05941-8 RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis via ERK inhibition.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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