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  • 1
    Electronic Resource
    Electronic Resource
    Distribution and functional significance of the endothelin receptor subtypes in the rat adrenal gland (1997)
    Springer
    Cell & tissue research 288 (1997), S. 345-352 
    Details
    ISSN: 1432-0878
    Keywords: Key words: Endothelins ; Endothelin receptors ; Adrenal gland ; Steroid secretion ; Catecholamine secretion ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Endothelins (ET) are a family of vasoactive peptides that act via two subtypes of receptors, named ETA and ETB. ET-1 binds to both ETA and ETB, whereas the isopeptide ET-3 preferentially binds to ETB. The localization of ETA and ETB receptors in the rat adrenal gland and their involvement in the adrenal secretagogue effect of ETs has been studied in vitro. Autoradiographic assessment of the selective displacement of [125I]ET-1, [125I]ET-3 and [125I]BQ-3020 (an ETB agonist) by BQ-123 or BQ-788 (specific antagonists of ETA and ETB, respectively) indicates that the zona glomerulosa and adrenal medulla possess both ETA and ETB, whereas the zona fasciculata/reticularis is exclusively provided with ETB. ET-1, ET-3 and BQ-3020 enhance aldosterone and corticosterone secretion by dispersed cells of the zona glomerulosa and zona fasciculata/reticularis, respectively. BQ-123 does not affect the secretagogue action of these three agonists, whereas BQ-788 completely annuls it. ET-1 induces a marked rise in catecholamine release by fragments of the adrenal medulla, and both BQ-123 and BQ-788 partially reverse this effect. ET-3 and BQ-3020 elicit a catecholamine release that is less intense than that produced by ET-1; this response is unaffected by BQ-123 and abolished by BQ-788. Thus, in the rat, the corticosteroid secretagogue effect of ETs seems to be exclusively mediated by the ETB receptor subtype, and the catecholamine secretagogue action by both ETA and ETB. The functional relevance of ETA receptors present in the zona glomerulosa remains to be investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004410050820
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats (1993)
    Springer
    Cell & tissue research 272 (1993), S. 439-445 
    Details
    ISSN: 1432-0878
    Keywords: Adrenal growth ; CRH ; ACTH ; Hypophysectomy ; Electron microscopy ; Rat (Wistar)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Within two weeks, hypophysectomy induced in rats a striking decrease in the level of circulating ACTH (the concentration of which was at the limit of sensitivity of our assay system), coupled with a net reduction in the plasma corticosterone concentration and an evident adrenal atrophy. Zona fasciculata, the main producer of glucocorticoids, was decreased in volume, due to a lowering in both the number and average volume of its parenchymal cells. Subcutaneous ACTH infusion (0.1 pmol·min-1), administered during the last week following hypophysectomy, restored the normal blood level of ACTH and completely reversed all effects of hypophysectomy on the adrenals. Subcutaneous infusion for one week with α-helical-CRH or corticotropin-inhibiting peptide (1 nmol·min-1), which are competitive inhibitors of CRH and ACTH, evoked a further significant lowering of plasma corticosterone concentration and markedly enhanced adrenal atrophy in hypophysectomized rats. These findings strongly suggest that an extrahypothalamic pituitary CRH/ACTH system may be involved in the maintenance of the growth and steroidogenic secretory activity of the rat adrenal cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318550
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  • 3
    Electronic Resource
    Electronic Resource
    Selektive Alkylierung von mehrbasigen Säuren des 4-bindigen Phosphors mit Trialkylphosphit (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 2589-2592 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Selective Alkylation of Polybasic Phosphoric Acids with Trialkyl PhosphiteThe synthesis of mono-, di-, and triethyl phosphate (1-3) as well as of mono- and diethyl phenylmethane phosphonate (4, 5) by selective alkylation of orthophosphoric and phenylmethane phosphonic acid with triethyl phosphite is described.
    Notes: Die Synthese von Phosphorsäure-monoäthylester, -diäthylester und -triäthylester (1-3) sowie von Phenylmethanphosphonsäure-monoäthylester und -diäthylester (4, 5) durch selektive Alkylierung der Orthophosphorsäure und Phenylmethanphosphonsäure mit Triäthylphosphit wird beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080813
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Kinetik der Pistschimuka-Reaktion (1975)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 108 (1975), S. 2465-2468 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Kinetics of the Pistschimuka ReactionReactions of O,O,O-triethyl phosphoroselenoate and O,O,O-triethyl phosphorothioate with methyl iodide in N-methylacetamide were found to be of second order. The rate constants and the activation parameters are given.
    Notes: Selenophosphorsäure-O,O,O-triäthylester und Thiophosphorsäure-O,O,O-triäthylester reagieren mit Methyljodid in N-Methylacetamid nach einem Geschwindigkeitsgesetz 2. ordnung. Geschwindigkeitskonstanten und Aktivierungsparameter sind angegeben.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19751080733
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  • 5
    Electronic Resource
    Electronic Resource
    Mechanismus der thermischen Isomerisierung von Thiophosphorsäure-O-2-butenylester-O,O-dimethylester. Kinetische Untersuchung (1978)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 111 (1978), S. 56-64 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Mechanism of the Thermal Isomerisation of O-2-Butenyl O,O-Dimethyl Thiophosphate. Kinetic StudyThe thermal isomerisation of O-2-butenyl O,O-dimethyl thiophosphate (1b) (scheme 3) obeys first order rate law. Solvent polarity does not affect the parameters of activation, but influences a little the rate constants. The kinetic data and the observed “special” salt effect lead to the conclusion that the isomerisation proceeds by a dissociative mechanism. Ion pairs as intermediates are proposed.
    Notes: Die thermische Isomerisierung von Thiophosphorsäure-O-2-butenylester-O,O-dimethylester (1b) (Schema 3) verläuft nach einem Geschwindigkeitsgesetz 1. Ordnung. Die Polarität des Mediums beeinflußt nicht die Aktivierungsparameter und übt lediglich einen minimalen Einfluß auf die Geschwindigkeitskonstanten aus. Die kinetischen Daten und der festgestellte „spezielle“ Salzeffekt lassen den Schluß zu, daß diese Isomerisierung einem intramolekularen ionischen Mechanismus folgt. Als ionische Zwischenstufe werden Ionenpaare postuliert.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19781110105
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  • 6
    Electronic Resource
    Electronic Resource
    Thiophosphatidsäureester mit C—S—P-Bindung (1984)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1984 (1984), S. 1-7 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Thiophosphatidic Acid Esters Containing a C—S—P BondThiophosphatidic acid and the following thiophosphatidic acid esters containing a C—S—P bond were synthesized: O,O-dimethyl S-(2,3-distearoyloxypropyl) thiophosphate (4). O-methyl S-(2,3-distearoyloxypropyl) thiophosphoric acid (4a), and O,O-bis(trimethylsilyl) S-(2,3-distearoyloxypropyl) thiophosphate (6). The structures were proved by NMR and IR spectra. It was demonstrated that O,O-dimethyl S-(2,3-isopropylidenedioxypropyl) thiophosphate (3) can be obtained from 2,3-isopropylidenedioxy-1-propanethiol (1) in good yield and acylated to yield 4.
    Notes: Thiophosphatidsäure und folgende Thiophosphatidsäureester mit C—S—P-Bindung wurden synthetisiert: Thiophosphorsäure-O,O-dimethyl-S-(2,3-distearoyloxypropyl)ester (4), Thiophosphorsäure-O-methyl-S-(2,3-distearoyloxypropyl)ester (4a) und Thiophosphorsäure-O,O-bis(trimethylsilyl)-S-(2,3-distearoyloxypropyl)ester (6). Die Strukturen wurden durch NMR- und IR-Spektren bestätigt. Es wurde gezeigt, daß Thiophosphorsäure-O,O-dimethyl-S-(2,3-isopropylidendioxypropyl)ester (3) mit guter Ausbeute aus 2,3-Isopropylidendioxy-1-propanthiol (1) erhalten und zu 4 acyliert werden kann.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198419840102
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  • 7
    Electronic Resource
    Electronic Resource
    Neue Synthese des Thiophosphatidylcholins mit C — S — P-Bindung (1988)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1988 (1988), S. 191-193 
    Details
    ISSN: 0170-2041
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A New Synthesis of Thiophosphatidylcholine with C — S — P BondA convenient synthetic approach to thiophosphatidylcholine (6) involving phosphorylation of 2,3-bis(stearoyloxy)propansulfenyl chloride (2) with 2-triethylsiloxy-1,3,2-dioxaphospholane (3c) followed by aminolysis of the resulting 2-(2,3-distearoyloxypropylthio)-1,3,2-dioxaphospholane (4) using trimethylamine is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.198819880216
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  • 8
    Electronic Resource
    Electronic Resource
    Synthese des Thiophosphatidylcholins und seiner Analogen (1991)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1991 (1991), S. 833-834 
    Details
    ISSN: 0170-2041
    Keywords: Thiophosphatidylcholine, analogoues of ; 1,3,2-Dioxaphospholane, 2-(2,3-diacyloxypropylthio-), rearrangment of ; Thiophospholipids ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Synthesis of Thiophophatidylcholine and Its AnaloguesSynthesis of thiophatidylcholine 5, its phosphonothionate 7 and phosphonate 9 analogues are described. A novel facile rearrangement of 2-(2,3-distearoyloxypropylthio)-1,3,2-dioxaphospholane (3) into 2-(2,3-distearoyloxypropyl)-1,3,2-dioxaphospholane 2-sulfide (6) was observed by 13P-NMR spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.1991199101142
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  • 9
    Electronic Resource
    Electronic Resource
    Neue Synthesewege zu Thiophosphatidylcholin mit C—S—P-Bindung (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 923-925 
    Details
    ISSN: 0170-2041
    Keywords: 1-Propanethiol, 2,3-diacyloxy derivatives of ; Thiophospholipids ; Thiophosphatidylcholine ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: New Synthetic Routes to Thiophosphatidylcholine with C — S — P BondA simple and effective synthesis of thiophosphatidylcholine (4) based on phosphorylation of 2,3-di(stearoyloxy)-1-propa-nethiol (1a) or 2,3-di(stearoyloxy)-1-(trimethylsilyl)-1-propane-thiol (1b) with 2-chloro-2-oxo-1,3,2-dioxaphospholane (2) followed by ring opening of the resultant product 3 is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.1990199001169
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  • 10
    Electronic Resource
    Electronic Resource
    Etheranaloge der Thio- und Dithiophospholipide mit C—S—P-Bindung (1993)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1993 (1993), S. 1327-1329 
    Details
    ISSN: 0170-2041
    Keywords: Thiophospholipids ; Thioglycerol ; Dithioglycerol ; Phospholipids ; Lipids ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ether Analogues of Thio- and Dithiophospholipids with C-S-P BondThe efficient synthesis of 1-O-hexadecyl-2-O-methyl-3-thioglycero-3-phosphocholine (5a) and 1-S-hexadecyl-2-O-methyl-1,3-dithioglycero-3-phosphocholine (5b) based on phosphorylation of 1-O-hexadecyl-2-O-methyl-3-thioglycerol (3a) and 1-S-hexadecyl-2-O-methyl-1,3-dithioglycerol (3b) with 2-chloro-2-oxo-1,3,2-dioxaphospholane (6) followed by ring opening of the resulting intermediates 4a and 4b is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.1993199301216
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