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  • 1
    Electronic Resource
    Electronic Resource
    Reduction of conductance-based neuron models (1992)
    Springer
    Biological cybernetics 66 (1992), S. 381-387 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract We present a scheme for systematically reducing the number of differential equations required for biophysically realistic neuron models. The techniques are general, are designed to be applicable to a large set of such models and retain in the reduced system as high a degree of fidelity to the original system as possible. As examples, we provide reductions of the Hodgkin-Huxley system and the A-current model of Connor et al. (1977).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197717
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  • 2
    Electronic Resource
    Electronic Resource
    Frequency and burst duration in oscillating neurons and two-cell networks (1993)
    Springer
    Biological cybernetics 69 (1993), S. 375-383 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract We study the relationship of injected current to oscillator period in single neurons and two-cell model networks formed by reciprocal inhibitory synapses. Using a Morris-Lecar-like model, we identify two qualitative types of oscillatory behavior for single model neurons. The “classical” oscillator behavior is defined as type A. Here the burst duration is relatively constant and the frequency increases with depolarization. For oscillator type B, the frequency first increases and then decreases when depolarized, due to the variable burst duration. Our simulations show that relatively modest changes in the maximal inward and outward conductances can move the oscillator from one type to another. Cultured stomatogastric ganglion neurons exhibit both A and B type behaviors and can switch between the two types with pharmacological manipulation. Our simulations indicate that the stability of a two-cell network with injected current can be extended with inhibitory coupling. In addition, two-cell networks formed from type A or type B oscillators behave differently from each other at lower synaptic strengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00199437
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  • 3
    Electronic Resource
    Electronic Resource
    Frequency and burst duration in oscillating neurons and two-cell networks (1993)
    Springer
    Biological cybernetics 69 (1993), S. 375-383 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract We study the relationship of injected current to oscillator period in single neurons and two-cell model networks formed by reciprocal inhibitory synapses. Using a Morris-Lecar-like model, we identify two qualitative types of oscillatory behavior for single model neurons. The “classical” oscillator behavior is defined as type A. Here the burst duration is relatively constant and the frequency increases with depolarization. For oscillator type B, the frequency first increases and then decreases when depolarized, due to the variable burst duration. Our simulations show that relatively modest changes in the maximal inward and outward conductances can move the oscillator from one type to another. Cultured stomatogastric ganglion neurons exhibit both A and B type behaviors and can switch between the two types with pharmacological manipulation. Our simulations indicate that the stability of a two-cell network with injected current can be extended with inhibitory coupling. In addition, two-cell networks formed from type A or type B oscillators behave differently from each other at lower synaptic strengths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01185409
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  • 4
    Electronic Resource
    Electronic Resource
    Spike initiation and propagation on axons with slow inward currents (1993)
    Springer
    Biological cybernetics 68 (1993), S. 209-214 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract We investigate spike initiation and propagation in a model axon that has a slow regenerative conductance as well as the usual Hodgkin-Huxley type sodium and potassium conductances. We study the role of slow conductance in producing repetitive firing, compute the dispersion relation for an axon with an additional slow conductance, and show that under appropriate conditions such an axon can produce a traveling zone of secondary spike initiation. This study illustrates some of the complex dynamics shown by excitable membranes with fast and slow conductances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224853
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  • 5
    Electronic Resource
    Electronic Resource
    FROM BIOPHYSICS TO MODELS OF NETWORK FUNCTION (1998)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Neuroscience 21 (1998), S. 25-45 
    Details
    ISSN: 0147-006X
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Notes: Abstract Neurons and synapses display a rich range of time-dependent processes. Which of these are critical to understanding specific integrative functions in the brain? Computational methods of various kinds are used to understand how systems of neurons interact to produce behavior. However, these models often assume that neuronal dynamics and synaptic strengths are fixed. This review presents some recent models that illustrate that short-term synaptic plasticity mechanisms such as facilitation and depression can have important implications for network function. Other features of synaptic transmission such as multi-component synaptic potentials, cotransmission, and neuromodulation with obvious potential computational implications are presented. These examples illustrate that synaptic strength and intrinsic properties in networks are continuously varying on numerous time scales as a function of the temporal patterns of activity in the network. Thus, both firing frequency of the neurons in a circuit, and the modulatory environment determine the intrinsic and synaptic properties that produce behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.neuro.21.1.25
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  • 6
    Electronic Resource
    Electronic Resource
    Neurobiology Extending influence (2006)
    [s.l.] : Nature Publishing Group
    Nature 441 (2006), S. 702-703 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Much of what we know about electrical signalling in the brain comes from extracellular recordings that detect when a neuron is firing action potentials. These recordings do not, however, provide continuous monitoring of the fluctuations of membrane potential, and do not capture sub-threshold ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/441702a
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  • 7
    Electronic Resource
    Electronic Resource
    Acetylcholine as an excitatory neuromuscular transmitter in the stomatogastric system of the lobster (1974)
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 730-731 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The stomatogastric ganglion of the spiny lobster, Panulirus interruptus, contains about 30 neurones, 23 of which are motor neurones and make excitatory neuromuscular synapses with 38 pairs of striated muscles which move the lobster's stomach5. These muscles are typical of crustacea, with fibres ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/251730a0
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  • 8
    Electronic Resource
    Electronic Resource
    Moving rhythms (2001)
    [s.l.] : Nature Publishing Group
    Nature 410 (2001), S. 755-755 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One hundred years ago, neuroscientists watched children and cats walking, jumping and running, and realized that these and other rhythmic movements require the orderly and progressive activation of many different muscle groups. How does the nervous system achieve alternate contraction of extensor ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35071196
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  • 9
    Electronic Resource
    Electronic Resource
    Non-mammalian models for studying neural development and function (2002)
    [s.l.] : Nature Publishing Group
    Nature 417 (2002), S. 318-321 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Early neuroscientists scoured the animal kingdom for the ideal preparation with which to study specific problems of interest. Today, non-mammalian nervous systems continue to provide ideal platforms for the study of fundamental problems in neuroscience. Indeed, the peculiarities of body plan and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/417318a
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  • 10
    Electronic Resource
    Electronic Resource
    Plasticity in single neuron and circuit computations (2004)
    [s.l.] : Nature Publishing Group
    Nature 431 (2004), S. 789-795 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Plasticity in neural circuits can result from alterations in synaptic strength or connectivity, as well as from changes in the excitability of the neurons themselves. To better understand the role of plasticity in the brain, we need to establish how brain circuits work and the kinds of computations ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature03011
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