Publication Date:
2018-10-25
Description:
The signalling conformation of the insulin receptor ectodomain The signalling conformation of the insulin receptor ectodomain, Published online: 24 October 2018; doi:10.1038/s41467-018-06826-6 The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that sheds light on the mechanism of signal transduction.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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