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  • 1
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    Continuous animal exposure to dichloromethane (1972)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Continuous exposures of dogs, monkeys, rats and mice to 5000 ppm and 1000 ppm of dichloromethane vapor (CH2Cl2) produced severe toxic effects on dogs, rats and mice. Dogs died after 3 weeks exposure to 1000 ppm and after 6 weeks exposure to 5000 ppm. Thirty percent of the mice also succumbed during four weeks exposure to 5000 ppm CH2Cl2. Although rats survived 14 weeks exposure to 5000 ppm, they experienced subnormal weight gains. Significant gross and histopathological hepatic lesions were noted in all 3 species at death or experimental termination in 14 weeks. In addition, rats showed abnormal kidney histopathology. Fat stains disclosed mild fatty increase in monkey livers after 14 weeks exposure to 1000 ppm CH2Cl2.
    Keywords: BIOSCIENCES
    Type: NASA-CR-127698 , AMRL-TR-72-28 , W-71005
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 2
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    Effect of 90-day continuous exposure to methylisobutylketone on dogs, monkeys and rats (1971)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Continuous exposure of rats, dogs and monkeys to 410 mg/cu M methylisobutylketone vapor (MIBK) was conducted to evaluate the provisional spacecraft exposure limit of 20 ppm established by the Space Science Board in 1968. The exposure, conducted in a simulated space cabin environment, did not produce any measurable changes in dogs or monkeys. Rats developed hyaline droplet nephrosis within 2 weeks of exposure which was reversible upon removal from the MIBK even after 90 days. The data obtained indicated that the 60-minute emergency exposure limit of 100 ppm and the 90- and 1000-day provisional limits as established by the Space Science Board contain a wide margin of safety.
    Keywords: BIOSCIENCES
    Type: NASA-CR-126744 , W-71003 , AMRL-TR-71-65
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Effects of inhalation of Freon 113 on laboratory animals (1970)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: Four monkeys, 8 dogs, 40 mice, and 50 rats were exposed continuously to 2000 ppm Freon 113 in a Thomas Dome for 14 days. This exposure produced no mortalities nor adverse symptomology. There were no significant alterations in hematological values, clinical chemistries, electroencephalographic findings, body weights, or organ to body weight ratios. The effect of 2% Freon 113 on nicotinic transmission through the stellate ganglion of the spinal dog was also evaluated. The exposure induced a reduction in nicotinic transmission comparable to 2% halothane.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-67461 , AD-727524 , AMRL-TR-70-102-PAPER-20
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Toxic Hazards Research Unit annual technical report, 1972 (1972)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1971 through May 1972 are reviewed in this report. Acute inhalation toxicity experiments were conducted on hydrogen chloride (HCl) gas and aerosol, ethyl bromide (C2H5Br), hydrogen bromide (HBr), hydrogen sulfide (H2S), ammonia (NH3), chlorine (CL2), and silane (SiH4). Subacute toxicity studies were conducted on chlorine pentafluoride (ClF5), dichloromethane (CH2Cl2) and coal tar volatiles. Further toxicity studies of subacute and chronic responses to inhaled monomethylhydrazine (MMH) are also described.
    Keywords: BIOSCIENCES
    Type: NASA-CR-131675 , AD-755358 , W72003 , AMRL-TR-72-62
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Continuous exposure of animals to methylisobutylketone (1971)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Continuous exposure of dogs, monkeys, mice, and rats to MIBK for two weeks and all animals except mice for 90 days resulted in measurable adverse effects only in the case of rats. Rat kidney weights and kidney to body weight ratios were significantly elevated after exposure to 410 mg/cu m for two weeks, and kidney and liver organ weights and organ to body weight ratios were elevated after exposure to 820 mg/cu m for two weeks and to 410 mg/cu m for 90 days.
    Keywords: BIOSCIENCES
    Type: NASA-TM-X-69100 , AD-751443 , AMRL-TR-71-120-PAPER-22 , 2d Ann. Conf. on Environ. Toxicol.; Aug 31, 1971 - Sep 02, 1971; Fairborn, OH; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 6
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    A study of the biological effect of continuous inhalation exposure of 1, 1, 1-trichloroethene (methyl chloroform) on animals (1974)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The effects of continuous exposure to 1,1,1-trichloroethane on hepatic morphology and function are evaluated and compared with those produced by methylene chloride (dichloromethane) to determine environmental concentrations of each compound that would produce a similar biological response, i.e., a comparable increase in liver triglycerides over control levels. Experimental findings on mice, rats, dogs, and monkeys indicate that the pathological alternations observed with 1,1,1-trichloroethane are similar to those observed with dichloromethane except for different time courses of the effects and different degrees of recovery. A ten fold greater atmospheric concentration of 1,1,1-trichloroethane is required to produce the minimal liver changes found at 100 ppm dichloromethane.
    Keywords: BIOSCIENCES
    Type: NASA-CR-134323
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 7
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    Toxic Hazards Research Unit (1971)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The activities of the Toxic Hazards Research Unit (THRU) for the period of June 1970 through May 1971 reviewed. Modification of the animal exposure facilities primarily for improved human safety but also for experimental integrity and continuity are discussed. Acute toxicity experiments were conducted on hydrogen fluoride (HF), hydrogen chloride (HCl), nitrogen dioxide (NO2), and hydrogen cyanide (HCN) both singly and in combination with carbon dioxide (CO). Additional acute toxicity experiments were conducted on oxygen difluoride (OF2) and chlorine pentafluoride (ClF5). Subacute toxicity studies were conducted on methylisobutylketone and dichloromethane (methylene dichloride). The interim results of further chronic toxicity experiments on monomethylhydrazine (MMH) are also described.
    Keywords: BIOSCIENCES
    Type: NASA-CR-124835 , ATR-7 , W-71004 , AMRL-TR-71-83
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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