Publication Date:
2004-10-09
Description:
Almost all discussions of prebiotic chemistry assume that amino acids, nucleotides, and possibly other monomers were first formed on the Earth or brought to it in comets and meteorites, and then condensed nonenzymatically to form oligomeric products. However, attempts to demonstrate plausibly prebiotic polymerization reactions have met with limited success. We show that carbonyl sulfide (COS), a simple volcanic gas, brings about the formation of peptides from amino acids under mild conditions in aqueous solution. Depending on the reaction conditions and additives used, exposure of alpha-amino acids to COS generates peptides in yields of up to 80% in minutes to hours at room temperature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Leman, Luke -- Orgel, Leslie -- Ghadiri, M Reza -- New York, N.Y. -- Science. 2004 Oct 8;306(5694):283-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15472077" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acids/*chemistry
;
Anaerobiosis
;
Cyclization
;
Dipeptides/chemistry
;
*Evolution, Chemical
;
Magnetic Resonance Spectroscopy
;
Oligopeptides/*chemistry
;
Oxidation-Reduction
;
Phenylalanine/chemistry
;
Serine/chemistry
;
Sulfur Oxides/*chemistry
;
Temperature
;
Thermodynamics
;
Thiocarbamates/chemistry
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink