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  • 1
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    Identification of an RNA-protein bridge spanning the ribosomal subunit interface (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-25
    Description: The 7.8 angstrom crystal structure of the 70S ribosome reveals a discrete double-helical bridge (B4) that projects from the 50S subunit, making contact with the 30S subunit. Preliminary modeling studies localized its contact site, near the bottom of the platform, to the binding site for ribosomal protein S15. Directed hydroxyl radical probing from iron(II) tethered to S15 specifically cleaved nucleotides in the 715 loop of domain II of 23S ribosomal RNA, one of the known sites in 23S ribosomal RNA that are footprinted by the 30S subunit. Reconstitution studies show that protection of the 715 loop, but none of the other 30S-dependent protections, is correlated with the presence of S15 in the 30S subunit. The 715 loop is specifically protected by binding free S15 to 50S subunits. Moreover, the previously determined structure of a homologous stem-loop from U2 small nuclear RNA fits closely to the electron density of the bridge.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Culver, G M -- Cate, J H -- Yusupova, G Z -- Yusupov, M M -- Noller, H F -- 1F32GM18065-01/GM/NIGMS NIH HHS/ -- GM-17129/GM/NIGMS NIH HHS/ -- GM-59140/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Sep 24;285(5436):2133-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10497132" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Proteins/chemistry/metabolism ; Binding Sites ; Crystallography, X-Ray ; Escherichia coli/chemistry ; Hydroxyl Radical ; Nucleic Acid Conformation ; Protein Conformation ; RNA, Bacterial/*chemistry/metabolism ; RNA, Ribosomal, 23S/*chemistry/metabolism ; RNA, Small Nuclear/chemistry/metabolism ; Ribosomal Proteins/chemistry/*metabolism ; Ribosomes/*chemistry/metabolism/ultrastructure ; Thermus thermophilus/chemistry
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    X-ray crystal structures of 70S ribosome functional complexes (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-09-25
    Description: Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the interactions between tRNA and the ribosome, and of the packing arrangements of ribosomal RNA (rRNA) helices in and between the ribosomal subunits, can be seen. Numerous contacts are made between the 30S subunit and the P-tRNA anticodon stem-loop; in contrast, the anticodon region of A-tRNA is much more exposed. A complex network of molecular interactions suggestive of a functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, including interactions involving the "switch" helix and decoding site of 16S rRNA, and RNA bridges from the 50S subunit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cate, J H -- Yusupov, M M -- Yusupova, G Z -- Earnest, T N -- Noller, H F -- GM-17129/GM/NIGMS NIH HHS/ -- GM-59140/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1999 Sep 24;285(5436):2095-104.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA. cate@wi.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10497122" target="_blank"〉PubMed〈/a〉
    Keywords: Anticodon/metabolism ; Bacterial Proteins/chemistry/metabolism ; Base Pairing ; Binding Sites ; Crystallization ; Crystallography, X-Ray ; Fourier Analysis ; Models, Molecular ; Nucleic Acid Conformation ; Peptide Elongation Factors/metabolism ; Protein Biosynthesis ; Protein Conformation ; RNA, Bacterial/chemistry/metabolism ; RNA, Messenger/chemistry/metabolism ; RNA, Ribosomal/*chemistry/metabolism ; RNA, Ribosomal, 16S/chemistry ; RNA, Ribosomal, 23S/chemistry ; RNA, Transfer/*chemistry/metabolism ; Ribosomal Proteins/chemistry/metabolism ; Ribosomes/*chemistry/*physiology/ultrastructure ; Thermus thermophilus/*chemistry/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Crystal structure of the ribosome at 5.5 A resolution (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-03
    Description: We describe the crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution. All of the 16S, 23S, and 5S ribosomal RNA (rRNA) chains, the A-, P-, and E-site tRNAs, and most of the ribosomal proteins can be fitted to the electron density map. The core of the interface between the 30S small subunit and the 50S large subunit, where the tRNA substrates are bound, is dominated by RNA, with proteins located mainly at the periphery, consistent with ribosomal function being based on rRNA. In each of the three tRNA binding sites, the ribosome contacts all of the major elements of tRNA, providing an explanation for the conservation of tRNA structure. The tRNAs are closely juxtaposed with the intersubunit bridges, in a way that suggests coupling of the 20 to 50 angstrom movements associated with tRNA translocation with intersubunit movement.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yusupov, M M -- Yusupova, G Z -- Baucom, A -- Lieberman, K -- Earnest, T N -- Cate, J H -- Noller, H F -- New York, N.Y. -- Science. 2001 May 4;292(5518):883-96. Epub 2001 Mar 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular Biology of RNA, Sinsheimer Laboratories, University of California at Santa Cruz, Santa Cruz, CA 95064, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11283358" target="_blank"〉PubMed〈/a〉
    Keywords: Anticodon ; Bacterial Proteins/chemistry/metabolism ; Base Sequence ; Binding Sites ; Crystallography, X-Ray ; Models, Molecular ; Molecular Sequence Data ; Nucleic Acid Conformation ; Protein Biosynthesis ; Protein Conformation ; RNA, Bacterial/chemistry/metabolism ; RNA, Messenger/*chemistry/metabolism ; RNA, Ribosomal/*chemistry/metabolism ; RNA, Transfer/*chemistry/metabolism ; RNA, Transfer, Amino Acid-Specific/*chemistry/metabolism ; Ribosomal Proteins/*chemistry/metabolism ; Ribosomes/*chemistry/metabolism/*ultrastructure ; Thermus thermophilus/chemistry/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    X-ray structural investigation of the adduct of 1,3-di(tert-butyl)-2,4-di(tert-butylamido)diazadiphosphetidine with carbon disulfide and 2,5-diphenyl-3-cyclohexyl-4-oxo-4-cyclohexylamido-1,3,4-oxazaphospholidine (1991)
    Springer
    Journal of structural chemistry 32 (1991), S. 264-268 
    Details
    ISSN: 1573-8779
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An x-ray structural investigation of the products of the reactions of 1,3-di(tert-butyl)-2,4-di(tert-butylamido)diazadiphosphetidine and 1,3-dicyclohexyl-2,4-di(cyclohexylamido)diazadiphosphetidine with carbon disulfide and benzaldehyde, respectively, has been carried out (λMo, 2006 and 1484 reflections, R=0.038 and 0.083). It has been shown that in the former reaction the four-membered P2N2 ring is maintained, and a new exocyclic bond appears between one of its P atoms and the carbon atom of carbon disulfide with the formation of a zwitterionic adduct with the formula C15H38N4P2·CS2. In the latter case the P2N2 ring is opened, and a new five-membered heterocycle is closed with the formation of 2,5-diphenyl-3-cyclohexyl-4-oxo-4-cyclohexylamido-1,3,4-oxazaphospholidine C26H35O2N2P. The geometric parameters of both molecules investigated have been analyzed in detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00777199
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  • 5
    Electronic Resource
    Electronic Resource
    Berberis alkaloids. XXVI. An investigation of the alkaloids ofBerberis amurensis (1994)
    Springer
    Chemistry of natural compounds 29 (1994), S. 338-340 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In addition to alkaloids isolated previously, young shoots of Berberis amurensis Rupr. have yielded berberrubine, oxyacanthine, and pseudopalmatine, and the new amorphous base amurenine. It's structure has been established on the basis of spectral characteristics and chemical transformations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630534
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  • 6
    Electronic Resource
    Electronic Resource
    Berberis alkaloids. XV. Structure of bargustanine (1993)
    Springer
    Chemistry of natural compounds 29 (1993), S. 35-38 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Bargustanine (I), belonging to a new type of isoquinoline alkaloids, has been isolated from the phenolic fraction of the total alkaloids from the roots ofBerberis vulgaris L. Its structure has been established by chemical and spectral methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00631010
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  • 7
    Electronic Resource
    Electronic Resource
    Modification of the sesquiterpene lactone arteannuin B and antimicrobial activities of the products obtained (1997)
    Springer
    Chemistry of natural compounds 33 (1997), S. 554-557 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A number of amino derivatives have been synthesized from the sesquiterpene lactone arteannuin B, and quaternary salts have been obtained from them with alkyl halides. The results are given of a study of the antimicrobial activities of the modified derivatives.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02254803
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  • 8
    Electronic Resource
    Electronic Resource
    Berberis alkaloids. XL. An investigation of the alkaloids ofBerberis thunbergii (1997)
    Springer
    Chemistry of natural compounds 33 (1997), S. 599-599 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02254817
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  • 9
    Electronic Resource
    Electronic Resource
    Berberis alkaloids XIII. An investigation of the alkaloids of Berberis heteropoda (1993)
    Springer
    Chemistry of natural compounds 28 (1993), S. 523-524 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630680
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  • 10
    Electronic Resource
    Electronic Resource
    Berberis alkaloids. XVII. Investigation of the alkaloids of Berberis heteropoda (1993)
    Springer
    Chemistry of natural compounds 29 (1993), S. 43-48 
    Details
    ISSN: 1573-8388
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The alkaloid composition of young shoots and leaves ofBerberis heteropoda Schrenk has been studied. In addition to known alkaloids, two new ones have been isolated — N-methyldihydroberberine and 8-oxoberberrubine, the structures of which were established by chemical transformations and a study of spectral properties. Of known alkaloids, berbamunine, aromoline, glaucine, thalicmidine, isocorydine, and reticuline have been found in this plant for the first time. Pseudopalmitine and laudanosine have been found for the first time in plants of the genusBerberis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00631012
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