Publication Date:
1997-09-26
Description:
Mature single-positive (SP) T lymphocytes enter a "resting" state in which they are proliferatively quiescent and relatively resistant to apoptosis. The molecular mechanisms regulating this quiescent phenotype were unknown. Here it was found that the expression of a Kruppel-like zinc finger transcription factor, lung Kruppel-like factor (LKLF), is developmentally induced during the maturation of SP quiescent T cells and rapidly extinguished after SP T cell activation. LKLF-deficient T cells produced by gene targeting had a spontaneously activated phenotype and died in the spleen and lymph nodes from Fas ligand-induced apoptosis. Thus, LKLF is required to program the quiescent state of SP T cells and to maintain their viability in the peripheral lymphoid organs and blood.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuo, C T -- Veselits, M L -- Leiden, J M -- AI29637/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1997 Sep 26;277(5334):1986-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Chicago, Chicago, IL 60637, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9302292" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD95/biosynthesis
;
Apoptosis
;
B-Lymphocytes/metabolism
;
Cell Survival
;
Chimera
;
Fas Ligand Protein
;
Gene Deletion
;
Gene Targeting
;
*Interphase
;
Kruppel-Like Transcription Factors
;
Lymph Nodes/cytology
;
Lymphocyte Activation
;
Membrane Glycoproteins/biosynthesis
;
Mice
;
Mice, Inbred C57BL
;
Spleen/cytology
;
T-Lymphocyte Subsets/metabolism
;
T-Lymphocytes/*cytology/*immunology/metabolism
;
Trans-Activators/biosynthesis/genetics/*physiology
;
Transfection
;
*Zinc Fingers
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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