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  • 1
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    Modelling prehistoric land use and carbon budgets: A critical review (2011)
    Sage
    In: Holocene
    Details
    Publication Date: 2011-07-30
    Description: An evaluation of modelled estimates for C release following early land clearance at the global level based on new model assumptions suggests that earlier studies may have underestimated its magnitude, chiefly because of underestimation of the mid-Holocene global population. Alternative information sources for population and land utilisation support both a greater total CO 2 release and a greater Neolithic contribution. Indeed, we show that the quantity of terrestrial C release due to early farming, even using the most conservative assumptions, greatly exceeds the net terrestrial C release estimated by inverse modelling of ice core data by Elsig et al. (Elsig J, Schmitt J, Leuenberger D, Schneider R, Eyer M, Leuenberger M et al. (2009) Stable isotope constraints on Holocene carbon cycle changes from an Antarctic ice core. Nature 461: 507–510), though uncertainty about past global population estimates precludes calculation of a precise value.
    Print ISSN: 0959-6836
    Electronic ISSN: 1477-0911
    Topics: Geography , Geosciences
    Published by Sage
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  • 2
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    Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271 (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-07-03
    Description: The question of whether tumorigenic cancer stem cells exist in human melanomas has arisen in the last few years. Here we show that in melanomas, tumour stem cells (MTSCs, for melanoma tumour stem cells) can be isolated prospectively as a highly enriched CD271(+) MTSC population using a process that maximizes viable cell transplantation. The tumours sampled in this study were taken from a broad spectrum of sites and stages. High-viability cells isolated by fluorescence-activated cell sorting and re-suspended in a matrigel vehicle were implanted into T-, B- and natural-killer-deficient Rag2(-/-)gammac(-/-) mice. The CD271(+) subset of cells was the tumour-initiating population in 90% (nine out of ten) of melanomas tested. Transplantation of isolated CD271(+) melanoma cells into engrafted human skin or bone in Rag2(-/-)gammac(-/-) mice resulted in melanoma; however, melanoma did not develop after transplantation of isolated CD271(-) cells. We also show that in mice, tumours derived from transplanted human CD271(+) melanoma cells were capable of metastatsis in vivo. CD271(+) melanoma cells lacked expression of TYR, MART1 and MAGE in 86%, 69% and 68% of melanoma patients, respectively, which helps to explain why T-cell therapies directed at these antigens usually result in only temporary tumour shrinkage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898751/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898751/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boiko, Alexander D -- Razorenova, Olga V -- van de Rijn, Matt -- Swetter, Susan M -- Johnson, Denise L -- Ly, Daphne P -- Butler, Paris D -- Yang, George P -- Joshua, Benzion -- Kaplan, Michael J -- Longaker, Michael T -- Weissman, Irving L -- 1RC2 DE02077-01/DE/NIDCR NIH HHS/ -- F32 CA126252/CA/NCI NIH HHS/ -- F32 CA126252-03/CA/NCI NIH HHS/ -- UL1 RR025744/RR/NCRR NIH HHS/ -- England -- Nature. 2010 Jul 1;466(7302):133-7. doi: 10.1038/nature09161.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Stem Cell Biology and Regenerative Medicine, Stanford Cancer Center, Stanford University School of Medicine, Stanford, California 94304-5542, USA. aboiko@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20596026" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/analysis/metabolism ; Bone Transplantation ; Bone and Bones/pathology ; DNA-Binding Proteins/deficiency/genetics ; Humans ; Lung Neoplasms/secondary ; Melanoma/*metabolism/*pathology ; Melanoma-Specific Antigens ; Mice ; Mice, Knockout ; Neoplasm Metastasis ; Neoplasm Proteins/analysis/metabolism ; Neoplasm Transplantation ; Neoplastic Stem Cells/cytology/*metabolism/*pathology/transplantation ; Nerve Tissue Proteins/deficiency/genetics/*metabolism ; Neural Crest/cytology/*metabolism/pathology ; Receptors, Nerve Growth Factor/deficiency/genetics/*metabolism ; Skin/pathology ; Skin Transplantation ; Transplantation, Heterologous/pathology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Association of reactive oxygen species levels and radioresistance in cancer stem cells (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-06
    Description: The metabolism of oxygen, although central to life, produces reactive oxygen species (ROS) that have been implicated in processes as diverse as cancer, cardiovascular disease and ageing. It has recently been shown that central nervous system stem cells and haematopoietic stem cells and early progenitors contain lower levels of ROS than their more mature progeny, and that these differences are critical for maintaining stem cell function. We proposed that epithelial tissue stem cells and their cancer stem cell (CSC) counterparts may also share this property. Here we show that normal mammary epithelial stem cells contain lower concentrations of ROS than their more mature progeny cells. Notably, subsets of CSCs in some human and murine breast tumours contain lower ROS levels than corresponding non-tumorigenic cells (NTCs). Consistent with ROS being critical mediators of ionizing-radiation-induced cell killing, CSCs in these tumours develop less DNA damage and are preferentially spared after irradiation compared to NTCs. Lower ROS levels in CSCs are associated with increased expression of free radical scavenging systems. Pharmacological depletion of ROS scavengers in CSCs markedly decreases their clonogenicity and results in radiosensitization. These results indicate that, similar to normal tissue stem cells, subsets of CSCs in some tumours contain lower ROS levels and enhanced ROS defences compared to their non-tumorigenic progeny, which may contribute to tumour radioresistance.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778612/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778612/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Diehn, Maximilian -- Cho, Robert W -- Lobo, Neethan A -- Kalisky, Tomer -- Dorie, Mary Jo -- Kulp, Angela N -- Qian, Dalong -- Lam, Jessica S -- Ailles, Laurie E -- Wong, Manzhi -- Joshua, Benzion -- Kaplan, Michael J -- Wapnir, Irene -- Dirbas, Frederick M -- Somlo, George -- Garberoglio, Carlos -- Paz, Benjamin -- Shen, Jeannie -- Lau, Sean K -- Quake, Stephen R -- Brown, J Martin -- Weissman, Irving L -- Clarke, Michael F -- R01 CA100225/CA/NCI NIH HHS/ -- R01 CA100225-05/CA/NCI NIH HHS/ -- U54 CA126524/CA/NCI NIH HHS/ -- U54 CA126524-04/CA/NCI NIH HHS/ -- England -- Nature. 2009 Apr 9;458(7239):780-3. doi: 10.1038/nature07733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19194462" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Breast Neoplasms/physiopathology ; Cells, Cultured ; DNA Damage/genetics/radiation effects ; Female ; Gene Expression ; Humans ; Mammary Glands, Human/cytology/metabolism ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells/*metabolism/*radiation effects ; Radiation Tolerance/*physiology ; Reactive Oxygen Species/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
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    Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma (2007)
    National Academy of Sciences
    Details
    Publication Date: 2007-01-08
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 5
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    Reducing Global Turbulent Resistivity by Eliminating Large Eddies in a Spherical Liquid-Sodium Experiment (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-06-22
    Description: Author(s): E. J. Kaplan, M. M. Clark, M. D. Nornberg, K. Rahbarnia, A. M. Rasmus, N. Z. Taylor, C. B. Forest, and E. J. Spence Three-wave turbulent interactions and the role of eddy size on the turbulent electromotive force are studied in a spherical liquid-sodium dynamo experiment. A symmetric, equatorial baffle reduces the amplitude of the largest-scale turbulent eddies, which is inferred from the magnetic fluctuations sp... [Phys. Rev. Lett. 106, 254502] Published Tue Jun 21, 2011
    Keywords: Nonlinear Dynamics, Fluid Dynamics, Classical Optics, etc.
    Print ISSN: 0031-9007
    Electronic ISSN: 1079-7114
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Pre-Columbian deforestation as an amplifier of drought in Mesoamerica (2012)
    Wiley
    Details
    Publication Date: 2012-08-25
    Description: Droughts in pre-Columbian Mesoamerica caused significant societal disruptions during the Late Classic and Post-Classic Periods. While the primary causes of these droughts are still debated, it has been speculated that they may be linked to extensive deforestation associated with high population densities during these intervals. Here we show that pre-Columbian deforestation would have biased the climate in Mesoamerica towards a drier mean state, amplifying drought in the region. In climate model simulations using a pre-Columbian land cover reconstruction, annual precipitation decreases by 5%–15% throughout southern Mexico and the Yucatán compared to simulations using either natural forest cover or forest regrowth associated with population declines after 1500 C.E. These changes are driven primarily by large reductions (10%–20%) in precipitation during the late summer wet season (August–September). When compared to precipitation changes estimated to have occurred during the Maya collapse, our results suggest that deforestation could account for up to sixty percent of the mean drying during this interval. Many regions previously deforested in the pre-Columbian era are now under dense forest cover, indicating potential future climate impacts should tropical deforestation of these areas accelerate.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley on behalf of American Geophysical Union (AGU).
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  • 7
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    VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease (2019)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2019
    Description: 〈p〉Mitochondrial stress releases mitochondrial DNA (mtDNA) into the cytosol, thereby triggering the type I interferon (IFN) response. Mitochondrial outer membrane permeabilization, which is required for mtDNA release, has been extensively studied in apoptotic cells, but little is known about its role in live cells. We found that oxidatively stressed mitochondria release short mtDNA fragments via pores formed by the voltage-dependent anion channel (VDAC) oligomers in the mitochondrial outer membrane. Furthermore, the positively charged residues in the N-terminal domain of VDAC1 interact with mtDNA, promoting VDAC1 oligomerization. The VDAC oligomerization inhibitor VBIT-4 decreases mtDNA release, IFN signaling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus. Thus, inhibiting VDAC oligomerization is a potential therapeutic approach for diseases associated with mtDNA release.〈/p〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Specimen Collection for Translational Studies in Hidradenitis Suppurativa (2019)
    Springer Nature
    Details
    Publication Date: 2019-08-21
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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