Publication Date:
1993-02-12
Description:
Interferon regulatory factor-1 (IRF-1), a transcriptional activator, and IRF-2, its antagonistic repressor, have been identified as regulators of type I interferon and interferon-inducible genes. The IRF-1 gene is itself interferon-inducible and hence may be one of the target genes critical for interferon action. When the IRF-2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. This transformed phenotype was reversed by concomitant overexpression of the IRF-1 gene. Thus, restrained cell growth depends on a balance between these two mutually antagonistic transcription factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harada, H -- Kitagawa, M -- Tanaka, N -- Yamamoto, H -- Harada, K -- Ishihara, M -- Taniguchi, T -- New York, N.Y. -- Science. 1993 Feb 12;259(5097):971-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Molecular and Cellular Biology, Osaka University, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8438157" target="_blank"〉PubMed〈/a〉
Keywords:
3T3 Cells/metabolism
;
Animals
;
Blotting, Northern
;
Cell Transformation, Neoplastic/*genetics
;
Chromosome Mapping
;
Chromosomes, Human, Pair 5
;
DNA/biosynthesis
;
DNA-Binding Proteins/*genetics
;
*Gene Expression
;
Humans
;
Immunosorbent Techniques
;
Interferon Regulatory Factor-1
;
Interferon Regulatory Factor-2
;
Mice
;
Mice, Nude
;
Phenotype
;
Phosphoproteins/*genetics
;
Promoter Regions, Genetic
;
RNA, Messenger/genetics
;
*Repressor Proteins
;
*Transcription Factors
;
Transfection
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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