Publication Date:
1997-05-16
Description:
In many organisms, pattern formation in the embryo develops from the polarized distributions of messenger RNAs (mRNAs) in the egg. In Xenopus, the mRNA encoding Vg1, a growth factor involved in mesoderm induction, is localized to the vegetal cortex of oocytes. A protein named Vera was shown to be involved in Vg1 mRNA localization. Vera cofractionates with endoplasmic reticulum (ER) membranes, and endogenous Vg1 mRNA is associated with a subcompartment of the ER. Vera may promote mRNA localization in Xenopus oocytes by mediating an interaction between the Vg1 3' untranslated region and the ER subcompartment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deshler, J O -- Highett, M I -- Schnapp, B J -- GM16114-03/GM/NIGMS NIH HHS/ -- NS-26846/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1997 May 16;276(5315):1128-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9148809" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Biological Transport
;
Endoplasmic Reticulum/*metabolism
;
Glycoproteins/*genetics
;
Molecular Sequence Data
;
Mutation
;
Oocytes/*metabolism
;
Oogenesis
;
Protein Binding
;
Proteins/*metabolism
;
RNA, Messenger/genetics/*metabolism
;
Repetitive Sequences, Nucleic Acid
;
Transforming Growth Factor beta/*genetics
;
Xenopus Proteins
;
Xenopus laevis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
