Publication Date:
2015-08-08
Description:
The pathological assembly of Abeta, tau, and alpha-synuclein is at the heart of Alzheimer's and Parkinson's diseases. Extracellular deposits of Abeta and intraneuronal tau inclusions define Alzheimer's disease, whereas intracellular inclusions of alpha-synuclein make up the Lewy pathology of Parkinson's disease. Most cases of disease are sporadic, but some are inherited in a dominant manner. Mutations frequently occur in the genes encoding Abeta, tau, and alpha-synuclein. Overexpression of these mutant proteins can give rise to disease-associated phenotypes. Protein assembly begins in specific regions of the brain during the process of Alzheimer's and Parkinson's diseases, from where it spreads to other areas.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goedert, Michel -- U105184291/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2015 Aug 7;349(6248):1255555. doi: 10.1126/science.1255555.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK. mg@mrc-lmb.cam.ac.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26250687" target="_blank"〉PubMed〈/a〉
Keywords:
Alzheimer Disease/genetics/*metabolism/pathology
;
Amyloid beta-Protein Precursor/genetics/*metabolism
;
Brain/metabolism/pathology
;
Humans
;
Lewy Bodies/metabolism
;
Mutation
;
Parkinson Disease/genetics/*metabolism/pathology
;
Prion Diseases/*metabolism
;
Prions/genetics/*metabolism
;
alpha-Synuclein/genetics/*metabolism
;
tau Proteins/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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