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  • 1
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    Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-02-13
    Description: Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related proteins that play important roles in clathrin-mediated endocytosis. Here, we present the structure of the NH2-terminal domain of CALM bound to phosphatidylinositol-4,5- bisphosphate [PtdIns(4,5)P2] via a lysine-rich motif. This motif is found in other proteins predicted to have domains of similar structure (for example, Huntingtin interacting protein 1). The structure is in part similar to the epsin NH2-terminal (ENTH) domain, but epsin lacks the PtdIns(4,5)P2-binding site. Because AP180 could bind to PtdIns(4,5)P2 and clathrin simultaneously, it may serve to tether clathrin to the membrane. This was shown by using purified components and a budding assay on preformed lipid monolayers. In the presence of AP180, clathrin lattices formed on the monolayer. When AP2 was also present, coated pits were formed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ford, M G -- Pearse, B M -- Higgins, M K -- Vallis, Y -- Owen, D J -- Gibson, A -- Hopkins, C R -- Evans, P R -- McMahon, H T -- New York, N.Y. -- Science. 2001 Feb 9;291(5506):1051-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council (MRC) Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11161218" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptor Protein Complex 2 ; Adaptor Proteins, Vesicular Transport ; Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Binding Sites ; COS Cells ; Carrier Proteins/chemistry ; Cell Membrane/*metabolism ; Cercopithecus aethiops ; Clathrin/*metabolism ; Clathrin-Coated Vesicles/metabolism ; Coated Pits, Cell-Membrane/metabolism ; Crystallography, X-Ray ; Liposomes ; Models, Molecular ; Molecular Sequence Data ; *Monomeric Clathrin Assembly Proteins ; Nerve Tissue Proteins/chemistry/*metabolism ; Neuropeptides/chemistry ; Phosphatidylinositol 4,5-Diphosphate/*metabolism ; Phosphoproteins/chemistry/*metabolism ; Protein Conformation ; Protein Folding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; *Vesicular Transport Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The crystal structure of dynamin (2011)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2011-09-20
    Description: Dynamin-related proteins (DRPs) are multi-domain GTPases that function via oligomerization and GTP-dependent conformational changes to play central roles in regulating membrane structure across phylogenetic kingdoms. How DRPs harness self-assembly and GTP-dependent conformational changes to remodel membranes is not understood. Here we present the crystal structure of an assembly-deficient mammalian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state. The dynamin 1 monomer is an extended structure with the GTPase domain and bundle signalling element positioned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its opposing end. Dynamin 1 dimer and higher order dimer multimers form via interfaces located in the stalk. Analysis of these interfaces provides insight into DRP family member specificity and regulation and provides a framework for understanding the biogenesis of higher order DRP structures and the mechanism of DRP-mediated membrane scission events.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075756/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075756/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ford, Marijn G J -- Jenni, Simon -- Nunnari, Jodi -- DRG-2004-09/Howard Hughes Medical Institute/ -- R01 GM062942/GM/NIGMS NIH HHS/ -- R01 GM097432/GM/NIGMS NIH HHS/ -- R01GM062942S1/GM/NIGMS NIH HHS/ -- R01GM097432/GM/NIGMS NIH HHS/ -- England -- Nature. 2011 Sep 18;477(7366):561-6. doi: 10.1038/nature10441.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, University of California, Davis, Davis, California 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21927001" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Crystallization ; Crystallography, X-Ray ; Dynamin I/*chemistry/genetics/metabolism ; Guanosine Triphosphate/metabolism ; Humans ; Models, Molecular ; Molecular Sequence Data ; Nucleotides ; Protein Binding ; Protein Conformation ; Protein Multimerization/genetics ; Protein Structure, Tertiary/genetics ; Rats
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
    Electronic Resource
    Electronic Resource
    Evidence for Permeability Minima in Low-Pressure Gas Flow Through Porous Media (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 999-1000 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] FOR a gas flowing in a porous medium at a pressure such that l, the mean free path of the gas molecules, is much less than 2r, the mean pore diameter, it is well established1 that there is a linear relationship between K, the permeability (cm.2/sec.), and p, the mean pressure of the gas in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/182999a0
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Light-on and Light-off Effects on the Circadian Flight Activity in the Mosquito Anopheles gambiae (1966)
    [s.l.] : Nature Publishing Group
    Nature 211 (1966), S. 871-872 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Groups of females subjected to alternating periods of 12 h light and 12 h dark had periods of intense activity lasting about 20-30 min following both the light-on and the light-off signals. They were inactive during the remainder of the light period, but were usually active in "bursts" throughout ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/211871b0
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  • 5
    Electronic Resource
    Electronic Resource
    Gravel Bed Hydroponic Systems Used for Secondary and Tertiary Treatment of Sewage Effluent (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Water and environment journal 4 (1990), S. 0 
    Details
    ISSN: 1747-6593
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Gravel bed hydroponic (GBH) systems planted withemergent hydrophytes, such as Phragmites australis (the common reed), treat domestic sewage effluents to acceptable environmental standards in an economic and efficient manner. Biochemical oxygen demand (BOD), ammonia, and coliform bacteria can be reduced by over 90% and dissolved oxygen (DO) substantially increased. In temperate zones, such as Europe, GBH systems can be used to replace conventional small rural treatment works, and for tertiary treatment of final effluents. In tropical and arid zones, GBH systems can provide locally-managed, cost-effective alternatives to hightechnology systems which are inappropriate for use in developing countries. Portsmouth Polytechnic reed-bed sewage treatment GBH projects in the UK and Egypt are discussed and current progress is assessed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1747-6593.1990.tb01390.x
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  • 6
    Electronic Resource
    Electronic Resource
    Computer modelling of the meteorological and spraying parameters that influence the aerial dispersion of agrochemical sprays (1998)
    Springer
    International journal of biometeorology 41 (1998), S. 194-199 
    Details
    ISSN: 1432-1254
    Keywords: Key words Meteorology ; Turbulence ; Modelling ; Spray drift ; Wind
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract  An insight into the nature of prevailing meteorological conditions and the manner in which they interact with spraying parameters is an important prerequisite in the analysis of the dynamics of agrochemical sprays. Usually, when these sprays are projected from hydraulic nozzles, their initial velocity is greater than that of the ambient wind speed. The flowfield therefore experiences changes in speed and direction which are felt upstream as well as downstream of the spray droplets. The pattern of the droplet flow, i.e. the shape of the streamlines marking typical trajectories, will be determined by a balance of viscous forces related to wind speed, inertial forces resulting from the acceleration of the airstream and pressure forces which can be viewed in terms of the drag forces exerted on the spray droplets themselves. At a certain distance in the ensuing motion, when the initial velocity of the spray droplets has decreased sufficiently for there to be no acceleration, their trajectories will be controlled entirely by the random effects of turbulence. These two transport processes in the atmosphere can be modelled mathematically using computers. This paper presents a model that considers the velocity of spray droplets to consist of a ballistic velocity component superimposed by a random-walk velocity component. The model is used to study the influence of meteorological and spraying parameters on the three-dimensional dynamics of spray droplets projected in specified directions in neutral and unstable weather conditions. The ballistic and random-walk velocity components are scaled by factors of (1–ξ) and ξ respectively, where ξ is the ratio of the sedimentation velocity and the relative velocity between the spray droplets and the surrounding airstream. This ratio increases progressively as the initial velocity of the spray droplet decreases with air resistance and attains a maximum when the sedimentation velocity has been reached. As soon as this occurs, the random-walk process predominates. The computed effects of the release height of spray droplets, atmospheric turbulence intensity, evaporation, drop size spectrum, wind velocity and wind direction on the transport process have been studied and an analysis of spray drift is provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004840050074
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  • 7
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    Understanding the bacterial polysaccharide antigenicity of Streptococcus agalactiae versus Streptococcus pneumoniae (2006)
    National Academy of Sciences
    Details
    Publication Date: 2006-05-16
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 8
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    A retrospective analysis of funding and focus in US advanced fission innovation (2017)
    Institute of Physics (IOP)
    Details
    Publication Date: 2017-08-10
    Description: Deep decarbonization of the global energy system will require large investments in energy innovation and the deployment of new technologies. While many studies have focused on the expenditure that will be needed, here we focus on how government has spent public sector resources on innovation for a key carbon-free technology: advanced nuclear. We focus on nuclear power because it has been contributing almost 20% of total US electric generation, and because the US program in this area has historically been the world’s leading effort. Using extensive data acquired through the Freedom of Information Act, we reconstruct the budget history of the Department of Energy’s program to develop advanced, non-light water nuclear reactors. Our analysis shows that—despite spending $2 billion since the late 1990s—no advanced design is ready for deployment. Even if the program had been well designed, it still would have been insufficient to demonstrate even one non-light water technology. ...
    Print ISSN: 1748-9318
    Electronic ISSN: 1748-9326
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering
    Published by Institute of Physics (IOP)
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  • 9
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    Computer modelling of the meteorological and spraying parameters that influence the aerial dispersion of agrochemical sprays (1998)
    Springer
    Details
    Publication Date: 1998-04-21
    Print ISSN: 0020-7128
    Electronic ISSN: 1432-1254
    Topics: Geography , Physics
    Published by Springer
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  • 10
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    Vicinity analysis: a methodology for the identification of similar protein active sites (2008)
    Springer
    Details
    Publication Date: 2008-12-16
    Print ISSN: 1610-2940
    Electronic ISSN: 0948-5023
    Topics: Chemistry and Pharmacology
    Published by Springer
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